Small-animal radionuclide imaging with focusing gamma-ray optics

Pivovaroff, M. J.; Barber, William B.; Christensen, Finn Erland; Craig, William W.; Decker, Todd; Epstein, Michael; Funk, Tobias; Hailey, Charles J.; Hasegawa, B.H.; Hill, R.M.; Jernigan, J. G.; Taylor, Carmen; Ziock, Klaus P.

doi:10.1117/12.511741

Cited by 9 publications

(11 citation statements)

References 42 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In §4, we present data from our most recent prototype optics that have a measured spatial resolution of 185 µm, an order of magnitude better than our initial system. 20 We conclude in §5 with a discussion of near-term goals and the prospects of using focusing optics for performing radionuclide studies.…”

Section: A New Approach: Focusing Opticsmentioning

confidence: 99%

“…A more detailed treatment can be found elsewhere. 20,21 Reflective systems rely on the total external reflection of light, a phenomenon that results from the fact that the index of refraction for all materials is less than unity at X-ray and gamma-ray energies. Typically, a high-energy photon would be simply absorbed by a slab of material.…”

Section: Basic Principlesmentioning

confidence: 99%

“…20 The process of slumping sheets of ultrasmooth glass into segments that are then coated with multilayers and assembled into an optic is well-developed 31 and has been used to achieve sub-arcminute mirror quality 32 (∆α = 40 ). While these substrates meet the goals of the astrophysics community and will be used in the upcoming NASA mission NuSTAR, 33 they have three major drawbacks for radionuclide imaging.…”

Section: Limitations Of Segmented Glassmentioning

confidence: 99%

“…The testing protocol used in this study followed protocols developed to evaluate lenses made earlier from thermally-formed glass 20 ; in addition, they utilized custom fabricated structures to mount and align the optic with respect to the source and detector. Here, we quickly review the essential aspects of the experiments.…”

Section: Experimental Apparatusmentioning

confidence: 99%

See 3 more Smart Citations

Progress of focusing x-ray and gamma-ray optics for small animal imaging

et al. 2005

View full text Add to dashboard Cite

Significant effort is currently being devoted to the development of noninvasive imaging systems that allow in vivo assessment of biological and biomolecular interactions in mice and other small animals. Ideally, one would like to discern these functional and metabolic relationships with in vivo radionuclide imaging at spatial resolutions approaching those that can be obtained using the anatomical imaging techniques (i.e., <100 µm), which would help to answer outstanding questions in many areas of biomedicine.In this paper, we report progress on our effort to develop high-resolution focusing X-ray and gamma-ray optics for small-animal radionuclide imaging. The use of reflective optics, in contrast to methods that rely on absorptive collimation like single-or multiple-pinhole cameras, decouples spatial resolution from sensitivity (efficiency). Our feasibility studies have refined and applied ray-tracing routines to design focusing optics for small animal studies. We also have adopted a replication technique to manufacture the X-ray mirrors, and which in experimental studies have demonstrated a spatial resolution of ∼190 µm. We conclude that focusing optics can be designed and fabricated for gamma-ray energies, and with spatial resolutions, and field of view suitable for in vivo biological studies. While the efficiency of a single optic is limited, fabrication methods now are being developed that may make it possible to develop imaging systems with multiple optics that could collect image data over study times that would be practical for performing radionuclide studies of small animals.

show abstract

Section: A New Approach: Focusing Opticsmentioning

confidence: 99%

Section: Basic Principlesmentioning

confidence: 99%

Section: Limitations Of Segmented Glassmentioning

confidence: 99%

Section: Experimental Apparatusmentioning

confidence: 99%

See 2 more Smart Citations

Progress of focusing x-ray and gamma-ray optics for small animal imaging

et al. 2005

View full text Add to dashboard Cite

show abstract

“…It is beyond the scope of this paper to discuss the underlying physics of these systems and the important design drivers for biomedical applications. Instead, we briefly summarize the salient points and refer the interested reader to [Pivovaroff et al, 2003] for a detailed discussion. Figure 1.3 sketches the basic geometry of the γ-ray lens.…”

Section: Radionuclide Imagingmentioning

confidence: 99%

High-Resolution Radionuclide Imaging Using Focusing Gamma-Ray Optics

Pivovaroff

Barber

Funk

et al.

Small-Animal Spect Imaging

Self Cite

View full text Add to dashboard Cite

Significant effort is being devoted to the development of noninvasive imaging systems that allow in vivo assessment of biological and biomolecular interactions in mice and other small animals. Although single-photon emission tomography (SPECT) and positron emission tomography (PET) are well-matched to the study of physiological function in small animals, the spatial resolutions of 1−2 mm currently achievable with these techniques limits the types of research possible. For this reason, we are developing a small animal radionuclide imaging system using grazing incidence optics to focus the low-energy gamma-rays emitted by 125 I, 95m Tc, 96 Tc, and 99m Tc. We compare this approach to the more traditional use of absorptive collimation.

show abstract

A novel lobster-eye imaging system based on Schmidt-type objective for X-ray-backscattering inspection

Wang

Zhan

et al. 2016

Review of Scientific Instruments

View full text Add to dashboard Cite

This paper presents a novel lobster-eye imaging system for X-ray-backscattering inspection. The system was designed by modifying the Schmidt geometry into a treble-lens structure in order to reduce the resolution difference between the vertical and horizontal directions, as indicated by ray-tracing simulations. The lobster-eye X-ray imaging system is capable of operating over a wide range of photon energies up to 100 keV. In addition, the optics of the lobster-eye X-ray imaging system was tested to verify that they meet the requirements. X-ray-backscattering imaging experiments were performed in which T-shaped polymethyl-methacrylate objects were imaged by the lobster-eye X-ray imaging system based on both the double-lens and treble-lens Schmidt objectives. The results show similar resolution of the treble-lens Schmidt objective in both the vertical and horizontal directions. Moreover, imaging experiments were performed using a second treble-lens Schmidt objective with higher resolution. The results show that for a field of view of over 200 mm and with a 500 mm object distance, this lobster-eye X-ray imaging system based on a treble-lens Schmidt objective offers a spatial resolution of approximately 3 mm.

show abstract

Small-animal radionuclide imaging with focusing gamma-ray optics

Cited by 9 publications

References 42 publications

Progress of focusing x-ray and gamma-ray optics for small animal imaging

Progress of focusing x-ray and gamma-ray optics for small animal imaging

High-Resolution Radionuclide Imaging Using Focusing Gamma-Ray Optics

A novel lobster-eye imaging system based on Schmidt-type objective for X-ray-backscattering inspection

Contact Info

Product

Resources

About