This chapter describes a design of prototype of mobile heart monitoring system based on the Texas Instruments ADS1298R ECG front end and NRF52832 wireless data transmission chip. The described design and technical details allow developing a new mobile heart monitoring system consisting of ECG recording device, mobile computer (smartphone or tablet). The algorithm for ECG recovery using a reverse filter, whose parameters are determined by means of bioimpedance measurement, is described. The new algorithm of J-point detection is described and examined on the test ECG database. The detection rate is from 88% to 93%. It will allow mobile monitoring system to inform the user about any signs of dangerous heart condition in ECG. The chapter also describes experimental results of wireless protocol bandwidth and contact break detection. The results confirm the efficiency of the proposed technical solutions to mobile heart monitoring for wide range of applications from sports and fitness to monitoring for medical reasons.