Small Cell Carcinoma of the Esophagus: A SEER Database Analysis

Kukar, Moshim; Groman, Adrienne; Malhotra, Usha; Warren, Graham; Bogner, Paul N.; Nwogu, Chukwumere; Demmy, Todd L.; Yendamuri, Sai

doi:10.1245/s10434-013-3167-3

Cited by 61 publications

(63 citation statements)

References 30 publications

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“…The consensus on treatment, including the role of chemotherapy, radiation, and surgical treatment, remains controversial [6], especially because small cell carcinoma of the lung is largely considered nonsurgical. However, the reports do suggest that surgical resection should be considered in small cell carcinoma of the esophagus, as do our data here [7]. In fact, 3 of the 4 patients with diagnoses of small cell carcinoma have survived more than 8 years after surgical resection.…”

Section: Commentsupporting

confidence: 63%

Surgical Resection of Rare Esophageal Cancers

Saddoughi

Taswell

Harmsen

et al. 2016

The Annals of Thoracic Surgery

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Section: Commentsupporting

confidence: 63%

Surgical Resection of Rare Esophageal Cancers

Saddoughi

Taswell

Harmsen

et al. 2016

The Annals of Thoracic Surgery

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“…To our best knowledge, recently published studies with relatively large cases exploring the role of surgery in treating limited disease stage esophageal NEC have yield a median survival time of 10.1 to 28.5 months (9,16,(22)(23)(24), while patients treated with chemoradiotherapy alone yielded a median survival time of 8.0 to 16.1 months (25)(26)(27). Therefore, it seemed that surgery may benefit patients with limited stage esophageal NEC, but the role of surgery in treating esophageal NEC still remains to be confirmed and validated (28). In our univariate analysis, adjutant therapy could significantly increase survival time of the patients (median survival time: >28.2 and 14.6 months respectively, P=0.017), which was also commonly observed in previous studies (16,29).…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine carcinoma of the esophagus: clinical characteristics and prognostic evaluation of 49 cases with surgical resection

Deng¹,

Ni²,

Wang³

et al. 2016

J. Thorac. Dis.

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“…Primary small cell carcinoma of the esophagus (SCCE) is a highly aggressive malignancy with early metastasis and a dismal prognosis . Because of the rarity of the disease, the optimal standard treatment for SCCE remains undetermined.…”

Section: Introductionmentioning

confidence: 99%

Primary small cell carcinoma of the esophagus: Comparison between a Chinese cohort and Surveillance, Epidemiology, and End Results (SEER) data

Xiao

Ouyang

et al. 2019

Cancer Medicine

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Background The optimal standard treatment for primary small cell carcinoma of the esophagus (SCCE) remains undetermined. In this study, we conducted two areas of research on SCCE. First, we analyzed differences in SCCE characteristics between Chinese and U.S. patients. Second, we evaluated optimal treatment strategies for SCCE in the Chinese cohort. Methods Data from 137 Chinese SCCE patients collected from two cancer centers in China were compared with 385 SCCE patients registered in the U.S. SEER program. Prognostic factors were further analyzed in the Chinese group. Propensity score matching (PSM) was used to balance baseline features between the groups. Results There were more Chinese SCCE patients with regional stage disease (41.6%) and surgery was the principal local therapy (78.1%), while 51.7% of U.S. patients was at advanced stages and tended to receive radiotherapy as the main therapy (45.2%). Median overall survival (MST) of Chinese patients was 15.0 months, compared with 8.0 months for U.S. patients (P < 0.001). However, the survival differences between groups disappeared after PSM (MST: 12.5 m vs 9.0 m, P = 0.144). Further analysis found that surgery tended to achieve clinical benefits only for patients with localized disease (T1‐4aN0M0). Radiotherapy and chemotherapy may prolong survival in patients with regional and extensive disease. Conclusions Although there are huge differences in the tumor characteristics and treatment modalities of SCCE between Chinese and U.S. patients, the prognosis of SCCE is equally poor in both. Surgery should be considered for patients with localized disease, while chemoradiotherapy is recommended for patients with regional and extensive disease.

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Small Cell Carcinoma of the Esophagus: A SEER Database Analysis

Abstract: SCC of the esophagus presents at an advanced stage and confers a poor prognosis. The survival benefit of surgery and radiotherapy suggests that all esophageal SCC patients should be considered for preoperative radiotherapy and surgery in a stage-appropriate fashion.

Cited by 61 publications

References 30 publications

Surgical Resection of Rare Esophageal Cancers

Surgical Resection of Rare Esophageal Cancers

Neuroendocrine carcinoma of the esophagus: clinical characteristics and prognostic evaluation of 49 cases with surgical resection

Primary small cell carcinoma of the esophagus: Comparison between a Chinese cohort and Surveillance, Epidemiology, and End Results (SEER) data

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