Small cell carcinoma of the submandibular gland: a rare small round blue cell tumor

<p>Clinicopathological Characteristics and Survival of Small Cell Carcinoma of the Salivary Gland: a Population-Based Study</p>

“…Servato et al found that nodal metastasis appeared not to have prognosis significance with no significant difference in 5-year survival time between patients with and without lymph node metastases, but Walters et al's study reported that all patients with lymph node metastases died of their malignancies. 2,3 Our data also support the effect of lymph node metastases on outcome of those patients. Although there is no significant difference in prognosis between N1 patients and N2 patients, the survival time is much better in lymph node negative patients than positive patients.…”

“…2 Also, previous case reports found that patients with tumors larger than 5 cm in diameter could not survive over 24 months. 3,18 These findings demonstrate the importance of the size of the primary neoplasm as a predictor of the morbidity and mortality of patients with SmCC of the salivary gland. Except for tumor size, we did not observe any significant association between tumor location and prognosis in the present study.…”

“…Servato et al found that the CK20 immunostaining status is a prognostic factor for patients with SmCC of the salivary gland, but we could not evaluate this point due to inadequate information. 2,3 We could not account for the effect of potential advances in targeted therapy and immunotherapy, thus limiting our ability to describe treatment patterns for patients with SmCC of the salivary gland. Last, responses to treatment and recurrence rates could not be determined using these data from the SEER.…”

“…2 SmCC of the salivary gland could occur in both the major and minor salivary glands, with most cases affecting the parotid glands. 3 This rare cancer mainly occurs in men over 50 years of age. 4 The patients typically present with a painless mass which could develop rapidly over several months, then emerged gradually with pain, paraesthesia and facial nerve paralysis.…”

Poorly Differentiated Small-Cell Neuroendocrine carcinoma of the Submandibular Gland: A Case Report

“…3 The location of our patient's tumor in the submandibular gland is quite rare, as only 15 such cases have been previously reported in the English-language literature. [6][7][8][9][10] Preoperatively, some NECs are difficult to differentiate from a paraganglioma because of their vascularity and difficulty with biopsy as a result of their proximity to neurovascular structures in the neck. Once a biopsy has been obtained, immunohistochemical staining is important because it is independently diagnostic in 30 to 40% of cases.…”