Small Cell Neuroendocrine Carcinoma Masquerading as Cellulitis and Causing Blindness via Bilateral Orbital Involvement

Atik, Alp; Krilis, Matthew; Shannon, Kerwin F.

doi:10.3109/01676830.2013.772209

Cited by 15 publications

(16 citation statements)

References 12 publications

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“…5 There are reports of neuroendocrine carcinoma occurring as primary lesions of the orbit, ocular adnexa, and lacrimal gland, as well as the paranasal sinuses, with one previous reported entity of a primary lacrimal sac tumor. [5][6][7][8][9][10][11][12][13][14][15][16] Histopathological analysis of SCNECs may be hard to differentiate compared to other small round cell tumors including but not limited to metastatic lung primary small cell carcinoma, certain malignant lymphomas, melanomas, and most similarly Merkel cell carcinoma. 17 Regardless of the primary location of these tumors, their morphologic, ultrastructural, and immunohistochemical features are similar to pulmonary small cell carcinomas.…”

Section: Discussionmentioning

confidence: 99%

“…Though their rarity makes definitive patterns difficult, there have been at least 7 previously reported cases of sinonasal malignancies with extension into the orbit presenting with a myriad of symptoms (Table ). [5][6][7][8][9][10][11][12][13][14][15][16] It should be noted that none specifically presented as acute dacryocystitis. Theoretically, the DCR ostomy site could have allowed a local malignancy to easily enter the orbit in the patient.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Small Cell Neuroendocrine Carcinoma Presenting as Recurrent Dacryocystitis: Case Report of a Rare Entity

Amjad

Jacobs

Callahan

et al. 2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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An 84-year-old man presented with a localized, firm, tender mass over the right lacrimal sac. He had a history of acute dacryocystitis in the same eye 6 months before presentation, which resolved with antibiotics followed by uneventful dacryocystorhinostomy. At repeat presentation, the patient underwent orbital imaging and excisional biopsy of the lesion. Histologic studies revealed a small cell neuroendocrine carcinoma. The patient was subsequently treated with chemotherapy and radiation. Although there are rare reports of small cell neuroendocrine carcinoma originating in the sino-orbital-lacrimal region, this is the first report of tumor presentation with acute dacryocystitis in a patient with prior dacryocystorhinostomy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Small Cell Neuroendocrine Carcinoma Presenting as Recurrent Dacryocystitis: Case Report of a Rare Entity

Amjad

Jacobs

Callahan

et al. 2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…Along with typical, atypical carcinoid and esthesioneuroblastoma, they comprise the spectrum of neuroendocrine malignancies due to their similar cell of origin 1 . Presentation of sino nasal and orbital SNEC as an orbital neoplasm is exceedingly rare and to the authors’ best knowledge; there are only 3 reports of SNEC with primarily orbital involvement [2], [3], [4]. Authors hereby report the clinico- pathological features and behavior of SNEC of the orbit and paranasal sinus presenting as an orbital abscess in a young lactating female.…”

Section: Introductionmentioning

confidence: 99%

Small cell neuroendocrine carcinoma of the orbit presenting as an orbital abscess in a young female

Mittal

Kaza

Agarwal

et al. 2019

Saudi Journal of Ophthalmology

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Small cell neuroendocrine carcinoma (SNEC) of the sino-nasal tract is a rare tumor with aggressive behavior. Invasion of the orbit, brain and base of skull is reported in advanced cases, however clinical presentation of SNEC, primarily as an orbital mass is distinctly rare. A 25-year-old female, presented to a local ophthalmologist with sudden protrusion of eyeball and was diagnosed as an orbital abscess which was incised and drained. She presented to us after six months of initial drainage with rapid increase in protrusion and associated eyelid swelling and was lactating at the time of presentation. The patient underwent clinico-pathological work up and was diagnosed as a primary case of orbital SNEC. She received chemotherapy, with an initial response followed by massive recurrence and subsequently succumbed to the disease after 18 months of presentation to us.The authors present a literature review and describe the challenges in diagnosis and management of a primary orbital SNEC, which has high propensity to progress, recur, invade neighboring sites, and show distant metastasis inspite of multimodal therapy. Author's recommend close follow up during disease free intervals.

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“…Primary small cell neuroendocrine carcinomas (NECs) of extrapulmonary sites are extremely rare but are very important to diagnose because they are very aggressive [ 1 ]. Only one case of sinonasal small cell neuroendocrine carcinoma with orbital invasion has been reported, and the patient died in the second year of treatment [ 2 ]. Merkel cell carcinoma is an aggressive cutaneous NEC without hormonal syndromes, and 5 to 10% of Merkel cell carcinomas occur in the eyelids probably because the eyelids are frequently exposed to sunlight [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Primary Neuroendocrine Carcinoma of Ocular Adnexa

Yamanouchi

Oshitari

Nakamura

et al. 2013

Case Reports in Ophthalmological Medicine

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We present our findings in a case of primary neuroendocrine carcinoma (NEC) of the lacrimal gland and a case of primary Merkel cell carcinoma (MCC) of the eyelid. An 86-year-old man noticed a swelling of the left upper eyelid three months earlier. We performed excision biopsy and histopathological examination indicated that he had a primary NEC of the left lacrimal gland. He underwent chemotherapy followed by excision including the clinically visible margins and 50 Gy radiotherapy of the surgical margins. He had neither recurrence nor metastasis for 6 months since the last radiotherapy. An 80-year-old man noticed a nodule in the right upper eyelid and was referred to our hospital because the size was increasing rapidly. A complete surgical excision of the margins of the tumor was performed with histopathological confirmation of negative margins. The final diagnosis was a primary MCC of the right upper eyelid. After surgery, he underwent 50 Gy radiotherapy on the neck to prevent metastasis. No recurrence or metastasis was found for two years. Although primary NEC of the ocular adnexa is extremely rare, the tumor has high malignancy and readily metastasizes. Thus, combined therapy including surgery, radiotherapy, and/or chemotherapy is needed for complete management of NEC.

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Small Cell Neuroendocrine Carcinoma Masquerading as Cellulitis and Causing Blindness via Bilateral Orbital Involvement

Cited by 15 publications

References 12 publications

Small Cell Neuroendocrine Carcinoma Presenting as Recurrent Dacryocystitis: Case Report of a Rare Entity

Small Cell Neuroendocrine Carcinoma Presenting as Recurrent Dacryocystitis: Case Report of a Rare Entity

Small cell neuroendocrine carcinoma of the orbit presenting as an orbital abscess in a young female

Primary Neuroendocrine Carcinoma of Ocular Adnexa

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