Small Cell Neuroendocrine Carcinoma of the Cervix in Pregnancy: A Case Report and Review

Pan, Linglan; Liu, Lifen; Sheng, Xiujie; Chen, Dunjin

doi:10.1155/2019/8028459

Cited by 7 publications

(16 citation statements)

References 22 publications

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“… 6 17 In contrast to squamous cell cervical carcinoma which may allow for modest treatment delay due to pregnancy, immediate initiation of systemic treatment is recommended to improve maternal survival outcomes with the diagnosis of small cell cervical carcinoma. 5 16 19 In our case, chemotherapy was initiated in the second trimester to slow disease progression and preterm cesarean delivery was performed to allow earlier radiation therapy, affording our patient the best chance of prolongation of life.…”

Section: Discussionmentioning

confidence: 95%

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Small Cell Cervical Carcinoma in Pregnancy: Therapeutic Options for an Aggressive Cancer Diagnosis

Savelli Binsted,

Kassem,

et al. 2024

AJP Rep

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Neuroendocrine small cell cervical carcinoma is an aggressive cancer which accounts for approximately 1 to 3% of all cervical neoplasms. Therapy must be altered in pregnancy to optimize maternal–fetal outcomes. A 39-year-old woman presented for a routine prenatal visit and was noted to have a grossly abnormal cervix. Cervical biopsies confirmed small cell carcinoma. At 19 weeks' gestation, chemotherapy was initiated. The patient delivered at 34 weeks' gestation to initiate radiation therapy. Six months later, she was diagnosed with metastatic disease and died from cancer complications. In pregnancy, treatment modalities for small cell cervical carcinoma are based on the patient's gestational age at diagnosis. While aggressive early treatment is preferred, platinum-based chemotherapy can be initiated in the second trimester and radiation therapy delayed until delivery. Small cell cervical carcinoma complicating pregnancy requires aggressive treatment. Chemotherapy in the second trimester with planned delayed radiation therapy, may optimize fetal outcomes.

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Section: Discussionmentioning

confidence: 95%

“…However, in patients diagnosed in pregnancy, caution must be taken to ensure that pregnancy is maintained and risk to fetal development is minimized. 4 5 6 Our case highlights the treatment course of a patient who was incidentally found to have small cell cervical carcinoma during a routine prenatal visit.…”

mentioning

confidence: 88%

Small Cell Cervical Carcinoma in Pregnancy: Therapeutic Options for an Aggressive Cancer Diagnosis

Savelli Binsted,

Kassem,

et al. 2024

AJP Rep

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“…Definitive diagnosis is made via biopsy staining for at least two neuroendocrine tumor markers such as synaptophysin, CD56, chromogranin, and NSE [ 5 ]. Misdiagnosis on imaging is common for cervical myomas or rapidly growing cervical polyps [ 6 , 9 ]. Treatment is currently limited due to the lack of sufficient research to date [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Chemotherapy regimens are based on those used in small cell lung cancer, consisting of cisplatin and etoposide [ 5 ]. With early diagnosis, the prognosis can be up to five years, but as little as one month if diagnosed in the later stages [ 9 , 10 ]. Poor prognosis has also been seen in smokers as well [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Shoulder and Upper Back Pain: An Unusual Initial Presentation of Rare Stage IV Small Cell Neuroendocrine Cervical Cancer

Wong¹,

Abreu-Diaz²,

Kaur³

et al. 2022

Cureus

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While musculoskeletal pain is cited as the primary cause of disability and reason for visiting the emergency department in the United States, secondary etiologies should be considered. In this case report, we are reporting a unique case of a 38-year-old multiparous healthy female who presented to multiple emergency departments with fleeting pain on the shoulders and upper back. She was diagnosed with muscle spasms and joint arthritis and discharged home multiple times. The patient then developed vaginal bleeding, beltline numbness, and was found to have T6 spinal cord compression. Imaging prompted workup for malignancy, which revealed small cell neuroendocrine cervical cancer (SCNECC) with metastasis to intraabdominal lymph nodes, bone, and brain. SCNECC is very rare, aggressive, occurs in less than 3% of cervical cancers, and does not have established treatment guidelines. Because it is commonly misdiagnosed and has an overall poor prognosis, SCNECC can be missed if it is not part of the differential.

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“…General neoplasms are most often discovered in older individuals, but uterine cervical cancer is often detected in young patients. Pan et al 6 studied uterine cervical small-cell carcinomas that occurred during pregnancy, and the average age of their patients was 26.3 years. Those authors reported that over half of their patients with small-cell carcinoma during pregnancy died of that cancer.…”

Section: Discussionmentioning

confidence: 99%

Small-Cell Carcinoma of the Uterine Cervix Discovered With Quadriplegia Caused by Cervical Spine Metastasis

Oishi

Nishida

Takebayashi

et al. 2020

Clin Med Insights Case Rep

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Small-cell carcinoma of the uterine cervix is a rare and aggressive tumor, and the prognosis is poor compared with those of squamous cell carcinoma and adenocarcinoma of the uterine cervix, even when discovered at an earlier stage. We treated a patient with progressive small-cell carcinoma of the uterine cervix that metastasized to the cervical spine. The patient, a 73-year-old woman, presented with the symptom of numbness in her limbs. As she had difficulty moving her limbs (ie, quadriplegia), she was carried to an emergency room. A metastatic cervical spine tumor from the uterine cervical cancer was revealed by a computed tomography scan, and the patient was then transferred to our hospital’s neurosurgery department for treatment. We performed a resection of the cervical spine tumor and fixation of the spinal bone. Because the patient’s performance status was 4 and she remained bedridden 24 h/day, we could not perform systemic chemotherapy. We thus provided palliative care, including palliative radiotherapy, pain control, and rehabilitation to improve her limbs’ functioning. The patient died of the uterine cancer within approx. 6 months after the initiation of treatment. There is no established treatment for small-cell carcinoma as a gynecological lesion. For patients with progressive uterine cancer, the optimal treatments, including palliative care, must be determined.

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Small Cell Neuroendocrine Carcinoma of the Cervix in Pregnancy: A Case Report and Review

Cited by 7 publications

References 22 publications

Small Cell Cervical Carcinoma in Pregnancy: Therapeutic Options for an Aggressive Cancer Diagnosis

Small Cell Cervical Carcinoma in Pregnancy: Therapeutic Options for an Aggressive Cancer Diagnosis

Shoulder and Upper Back Pain: An Unusual Initial Presentation of Rare Stage IV Small Cell Neuroendocrine Cervical Cancer

Small-Cell Carcinoma of the Uterine Cervix Discovered With Quadriplegia Caused by Cervical Spine Metastasis

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