Small cell neuroendocrine carcinoma of the rectum associated with chronic ulcerative colitis

Rubin, A.; Pandya, Pooja

doi:10.1111/j.1365-2559.1990.tb01070.x

Cited by 21 publications

(10 citation statements)

References 6 publications

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“…[3][4][5][6][7] Poorly differentiated neuroendocrine carcinomas (NECs) are only anecdotally reported in association with Crohn's disease 7 and in ulcerative colitis (UC). [7][8][9][10][11][12][13][14][15][16][17][18] In this article, we report the case of a patient affected by UC who developed an NEC G3 of the sigmoid colon, and we review the clinicopathological features of the cases reported in literature.…”

Section: Introductionmentioning

confidence: 99%

Poorly Differentiated Neuroendocrine Carcinoma of the Sigmoid Tract in Long-Standing Ulcerative Colitis: Report of a Case and Review of the Literature

Bolzacchini¹,

Chini²,

Cortelezzi³

et al. 2018

Int J Surg Pathol

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A 37-year-old male with long-standing and extensive ulcerative pancolitis developed a rapidly lethal poorly differentiated neuroendocrine carcinoma (NEC) in the sigmoid colon. Prior biopsies obtained from multiple sites of the colon during endoscopic surveillance showed minimal inflammatory changes and no sign of dysplasia. Patients with inflammatory bowel disease (IBD) are at increased risk of colorectal malignancies, and adenocarcinoma is the most common type of colorectal neoplasm associated with ulcerative colitis and Crohn's disease, but other types of epithelial and nonepithelial tumors have also been described in IBD. NECs arising in the setting of ulcerative colitis are very rare and are reported as anecdotic findings. We describe the clinicopathological features of an IBD-related NEC and review the previously reported cases.

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Section: Introductionmentioning

confidence: 99%

Poorly Differentiated Neuroendocrine Carcinoma of the Sigmoid Tract in Long-Standing Ulcerative Colitis: Report of a Case and Review of the Literature

Bolzacchini¹,

Chini²,

Cortelezzi³

et al. 2018

Int J Surg Pathol

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“…Ils sont plus fréquents dans le sexe masculin avec un âge moyen de diagnostic de 50 ans [12] (notre patiente était âgée de 45 ans). Aucun facteur de risque n'est établi, cependant trois cas de carcinomes indifférenciés à petites cellules anorectaux ont été rapportés chez des hommes homosexuels et VIH positifs [10,13] et deux cas associés à une colite ulcérée [5,14].…”

Section: Discussionunclassified

“…Elles sont caractérisées par la présence de granules neurosécrétoires exprimant différents peptides, et c'est l'immunohistochimie qui les met en évidence. Pour le canal anal, c'est essentiellement le NSE, le Leu-7 (CD57), la chromogranine A (CGA), la synaptophysine (notre cas) et la sérotonine qui sont les plus retrouvés [6,10,11,14,[18][19][20][21][22]. Actuellement, le diagnostic de carcinomes à petites cellules est posé grâce à l'association de deux éléments, l'aspect histomorphologique et au moins deux réactions immunohistochimiques positives.…”

Section: Discussionunclassified

Traitement par radiochimiothérapie d’un carcinome endocrine indifférencié du canal anal : à propos d’un cas

Benkirane

Ouazzani

Mernissi

et al. 2010

J Afr Hepato Gastroenterol

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Le carcinome endocrine indifférencié du canal anal est un cancer rare de mauvais pronostic lié à la fréquence des métastases hépatiques et pulmonaires. La plupart des malades ont une maladie métastatique au moment du diagnostic. Le traitement locorégional est le plus souvent chirurgical à type d'amputation abdominopelvienne, mais celle-ci n'est pas forcément évidente compte tenu de la mutilation qu'elle impose dans un contexte de fort risque métastatique et de décès à plus ou moins brève échéance. Nous rapportons un cas de carcinome endocrine indifférencié du canal anal localement évolué traité par radiothérapie externe suivie d'une chimiothérapie à base d'étoposide-cisplatine ayant permis d'obtenir une rémission complète locale et d'éviter une intervention d'exérèse qui aurait été mutilante. Une place importante pourrait ainsi être donnée au traitement non chirurgical en associant la radio-et la chimiothérapie. Mots clés Canal anal · Carcinome endocrine indifférencié · RadiochimiothérapieAbstract Undifferentiated endocrine carcinoma of anal canal is a rare cancer with a poor prognosis linked to the frequency of occurrence of hepatic and pulmonary metastasis. Most patients have metastatic disease at the time of diagnosis.The locoregional treatment is generally surgical as abdominopelvic excision, but this one is not obvious taking into consideration the mutilation which it does impose in a context of strong metastatic risk and death in the near short term. We report one case of undifferentiated endocrine carcinoma localized in the anal canal, and treated by external radiotherapy and a chemotherapy regimen combining etoposide plus cisplatine resulting in prolonged complete local remission and preventing extended surgical excision. An important place could thus be given to the non surgical treatment combining radiotherapy and chemotherapy.

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“…Interestingly, in a report from Taiwan, there were 2 patients with small cell carcinomas that were believed to represent gastrointestinal metastases from a primary pulmonary site, possibly emphasizing the difficulty in defining their origin in some cases [6] . Scattered reports are available on poorly differentiated neuroendocrine carcinoma with inflammatory bowel disease have been notedwith an equally dismal outcome [7][8][9] . In a recent report by Grassia et al [1] , however, surveillance studies were completed during the preceding year, and yet, large lesions in the most distal colon were eventually detected later.…”

Section: To the Editormentioning

confidence: 99%

Lethal neuroendocrine carcinoma in ulcerative colitis

Freeman¹,

Berean²

2009

WJG

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A 48-year old male with longstanding and extensive pancolitis developed a high grade and rapidly lethal malignant lesion in the ascending colon characterized by a neuroendocrine carcinoma. Prior biopsies obtained from multiple sites in the colon during endoscopic surveillance were reported to show only inflammatory changes without dysplasia. Although operator-dependent, repeated endoscopic studies may have limitations during surveillance programs because the biological behavior of some colonic neoplastic lesions may have a rapid and very aggressive clinical course. TO THE EDITORAn article recently published in World Journal Gastroenterology concerning two patients, aged 35 and 77 years respectively, with left-sided ulcerative colitis, was of special importance [1] . In spite of colonoscopic and histologic follow-up in the previous year, both developed large neuroendocrine carcinomas in the rectum, and one patient was reported to have died due to multiple liver metastases.We had a similar experience in a 48-year old male with longstanding extensive pan-ulcerative colitis for 16 years, first diagnosed in 1992. During the clinical course, his symptoms were initially treated and controlled with 5-aminosalicylates and corticosteroids. Endoscopic studies eventually showed virtually complete mucosal healing and biopsies showed only minimal inflammatory changes. No other immunosuppressive drugs or biological agents were used. During the last decade, he continued to use 5-aminosalicylates alone and remained completely asymptomatic. He underwent repeated surveillance colonoscopies with multiple site biopsies throughout the colon, which showed minimal inflammatory changes. Dysplasia was not reported in any colonic biopsy specimen. Approximately ten months after his last endoscopic procedure, he developed right upper quadrant abdominal pain. Blood studies, including liver chemistry tests, were normal, but an ultrasound and a computerized tomographic (CT) scan suggested possible liver metastases. In addition, the CT suggested a focal thickening area in the ascending colon. Colonoscopy confirmed an ulcerated sessile lesion. Histologic examination of the endoscopic biopsies showed an ulcerating tumor with predominant trebecular architecture and vascular stroma. The tumor cells had hyperchromatic nuclei with small nucleoli and scant pale-stained cytoplasm. Mitoses were numerous and there was abundant apoptosis, consistent with a high grade malignancy. Immunohistochemical stain for chromogranin and synaptophysin showed moderately intense staining of a neuroendocrine carcinoma. Tumor cells were positive for CK7 and negative for CK-20. Subsequent studies also showed pulmonary metastases and palliative chemotherapy was provided with FOLFOX B (12 cycles), but the disease remained progressive so FOLFIRI (10 cycles) was given. He died fourteen months after diagnosis.Neuroendocrine carcinomas of the colon and rectum, accounting for less than 1% of colon and rectal cancers reported over more than a decade from Memorial SloanKet...

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Small cell neuroendocrine carcinoma of the rectum associated with chronic ulcerative colitis

Cited by 21 publications

References 6 publications

Poorly Differentiated Neuroendocrine Carcinoma of the Sigmoid Tract in Long-Standing Ulcerative Colitis: Report of a Case and Review of the Literature

Poorly Differentiated Neuroendocrine Carcinoma of the Sigmoid Tract in Long-Standing Ulcerative Colitis: Report of a Case and Review of the Literature

Traitement par radiochimiothérapie d’un carcinome endocrine indifférencié du canal anal : à propos d’un cas

Lethal neuroendocrine carcinoma in ulcerative colitis

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