Small diameter blood vessels with controllable micropore structure induced by centrifugal force for improved endothelialization

Abstract

The micropore structure is prerequisite for fast and durable endothelialization of artificial small diameter blood vessels (ASDBVs). Although some methods, such as salt leaching, coagulation, and electrospinning, have been developed to construct micropores for ASDBVs, the uncontrollability of the structure and the complicated procedures of the process are still the issues to be concerned about. In this study, a compact device based on the principle of centrifugal force is established and used to prepare polyurethane (PU) ASDBVs with micropore structures by blasting different porogens. It is found that the glass beads could construct micropores with regular round shape, uniform distribution, and controllable size (60-350 µm), which significantly improves the endothelialization of PU-based ASDBVs, especially when the pore size is about 60 µm. This method is easy-accessible and wide-applicable, which provides a new pathway for the research and development of ASDBVs. K E Y W O R D Scentrifugal force, endothelialization, micropore structure, polyurethane, small diameter blood vessel

Cylindrical Polyurethane Scaffold Fabricated Using the Phase Inversion Method: Influence of Process Parameters on Scaffolds’ Morphology and Mechanical Properties

“…The washed-out porogen produced larger voids, resulting in a more uneven wall thickness. The wall thickness of the obtained structures was similar to that found in literature reports [ 9 ]. The use of pre-mixed polymer and the porogen can often result in irregular pore shapes while retaining residual porogen in the structure [ 65 ].…”

“…In addition to bio- and hemocompatibility, one of these criteria is a surface with proper pore sizes [ 5 , 6 , 7 , 8 ]. A surface pore size adapted to the cell size will facilitate the process of their adhesion to a material and further proliferation [ 9 , 10 ]. Moreover, a well-chosen pore size will accelerate and improve the prosthesis’s integration with the surrounding tissues [ 11 ].…”

A Temperature and pH Dual‐Sensitive Multifunctional Polyurethane with Bacteria‐Triggered Antibacterial Activity

“…By controlling the type and proportion of soft segments (oligomeric polyols) and hard segments (diisocyanates and chain extenders), researchers have used polyurethane to create a diverse range of materials with a wide span of properties and product forms. [1] The microphase separation caused by the soft and DOI: 10.1002/marc.202300453 hard segments may lead to good biocompatibility, [2] which has attracted considerable attention and recognition for use in medical applications, such as artificial blood vessels, [3] catheters, [4] heart valves, [5] and wound dressing. [6] However, bacterial infection, which has caused higher economic burdens and pain to patients, [7,8] is a hidden danger that medical materials must address.…”