Small extracellular vesicles with nanomorphology memory promote osteogenesis

Magnetic nanocomposites for magneto-promoted osteogenesis: from simulation auxiliary design to experimental validation

“…The ideal biomaterials should have certain biological activities, such as promoting cell adhesion, spreading, growth or differentiation. 35 The spreading morphology of cells on the surface of biomaterials is an important manifestation of the cell state. Therefore, the adhesion and spreading behavior of MC3T3-E1 cells cultured on different substrates were evaluated by phalloidin/DAPI staining.…”

The memory effect of micro/nano-structures activating osteogenic differentiation of BMSCs

“…8 It is worth mentioning that the topography-triggered memory effect could be easily regulated by the length of topographic stimulation. Magically, Ma et al 19 also reported a theory of nanotopographic memory of small extracellular vesicles for bone regeneration. They found that small extracellular vesicles extracted from hBMSCs which were stimulated by nanotopography could copy the pro-osteogenesis effect from the nanotopography to enhance bone regeneration, which seemed to be consistent with our study.…”

Bioengineering extracellular vesicles: smart nanomaterials for bone regeneration

“…Titanium alloys have been widely used in numerous orthopaedic applications due to their biocompatibility, mechanical properties and osteoinductivity [ 131 , 132 ]. Due to these favourable properties, studies have investigated the use of these biomaterials as substrates for EV manufacture [ 133 , 134 ]. For example, Ma et al evaluated the impact of alkali and heat treatment to infer nanotopography on titanium surfaces and improve the osteogenic potency of MSC-derived EVs (Fig.…”