Small flies—Big discoveries: Nearly a century of <i>Drosophila</i> genetics and development

Letsou, Anthea; Bohmann, Dirk

doi:10.1002/dvdy.20307

Cited by 14 publications

(11 citation statements)

References 19 publications

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“…One of the earliest published examples of polytene chromosomes is of Chironimus salivary gland chromosomes found in Walther Flemming’s 1882 book, Zellsubstanz , Kern , und Zelltheilung ( Flemming 1882). In the 1930s, researchers began using polytene chromosomes as a new genetic tool, helping to make Drosophila one of the premier model organisms of the twentieth century (Heitz 1933; Painter 1933; Letsou and Bohmann 2005). Most of the descriptions of polytene chromosomes in insects are from the Diptera order.…”

Section: What Is a Polytene Chromosome And Where Are They Found?mentioning

confidence: 99%

Polyteny: still a giant player in chromosome research

Stormo

Fox

2017

Chromosome Res

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In this era of high-resolution mapping of chromosome territories, topological interactions, and chromatin states, it is increasingly appreciated that the positioning of chromosomes and their interactions within the nucleus is critical for cellular function. Due to their large size and distinctive structure, polytene chromosomes have contributed a wealth of knowledge regarding chromosome regulation. In this review, we discuss the diversity of polytene chromosomes in nature and in disease, examine the recurring structural features of polytene chromosomes in terms of what they reveal about chromosome biology, and discuss recent advances regarding how polytene chromosomes are assembled and disassembled. After over 130 years of study, these giant chromosomes are still powerful tools to understand chromosome biology.

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Section: What Is a Polytene Chromosome And Where Are They Found?mentioning

confidence: 99%

Polyteny: still a giant player in chromosome research

Stormo

Fox

2017

Chromosome Res

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“…The most important question to ask next is whether the effect of L. brevis and xylose isomerase on the locomotor activity of D. melanogaster is relevant to animal behaviour in general, including that of humans and other mammals. As with many other discoveries first made in D. melanogaster 8 , perfect correspondence with mammalian systems is unlikely. Schretter and colleagues' study does, however, alert microbiologists and those studying animal behaviour to pay attention to the enzymes of gut bacteria and their possible effects on sugar metabolism and on the neuronal circuits regulating walking activity.…”

Section: Gut Microbes Alter Fly Walking Activitymentioning

confidence: 92%

“…In mice and humans, ACMSD is most highly expressed in the liver and kidney 7 , and a recent study indicates that these are the main organs for Trp-dependent NAD + generation 8 . Katsyuba et al found that inhibition of the Acmsd gene increased NAD + locomotion is mediated by the modulation of known circuits that control behaviour and not through previously unknown regulatory mechanisms.…”

Section: Gut Microbes Alter Fly Walking Activitymentioning

confidence: 99%

Gut microbes alter the walking activity of fruit flies

Douglas¹

2018

Nature

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“…The fruit fly Drosophila melanogaster is one of the most important model organisms for experimental study of biological evolution (Letsou and Bohmann, 2005). Scientists have been eyewitnesses to the ''awesome power'' of Drosophila geneticsfrom the transmission geneticists best exemplified by Tomas Hunt Morgan (Nobel Prize winner, 1933) and his students, to the developmental geneticists who have been led by Edward B. Lewis, Christiane Nüsslein-Volhard, and Eric F. Wieschaus (Nobel Prize winners, 1995) (Letsou and Bohmann, 2005).…”

Section: Introductionmentioning

confidence: 99%

Quantitative mechanical evaluation and analysis of Drosophila embryos through the stages of embryogenesis

Shen

Zhang

Cozen

et al. 2008

Birth Defects Research Pt C

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The fruit fly Drosophila embryo is one of the most important model organisms in genetics and developmental biology research. To better understand the biomechanical properties involved in Drosophila embryo research, this work presents a mechanical characterization of living Drosophila embryos through the stages of embryogenesis. Measurements of the mechanical forces of Drosophila embryos are implemented using a novel, in situ, and minimally invasive force sensing tool with a resolution in the range of microN. The measurements offer an essential understanding of penetration force profiles during the microinjection of Drosophila embryos. Sequentially quantitative evaluation and analysis of the mechanical properties, such as Young's modulus, stiffness, and mechanical impedance of living Drosophila embryos are performed by extracting the force measurements throughout the stages of embryogenesis. Experimental results illustrate the changing mechanical properties of Drosophila embryos during development, and thus mathematical models are proposed. The evaluation provides a critical step toward better understanding of the biomechanical properties of Drosophila embryos during embryogenesis, and could contribute to more efficient and significant genetic and embryonic development research on Drosophila.

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Small flies—Big discoveries: Nearly a century of Drosophila genetics and development

Cited by 14 publications

References 19 publications

Polyteny: still a giant player in chromosome research

Polyteny: still a giant player in chromosome research

Gut microbes alter the walking activity of fruit flies

Quantitative mechanical evaluation and analysis of Drosophila embryos through the stages of embryogenesis

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