Small-for-Size Syndrome in the Rat: Does Size or Technique Matter?

Dahmen, Uta; Madrahimov, N.; Madrahimova, Fotima; Ji, Yuan; Schenk, Andrea; Dirsch, Olaf

doi:10.1016/j.jss.2007.09.010

Cited by 24 publications

(20 citation statements)

References 39 publications

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“…In previous studies, a 20-40% partial liver graft without arterial reconstruction has been reported as SFSG in rats (9-11). However, because SFSS depends not only on the graft weight but also on recipient status, anhepatic time and IRI, which was the primary aim of this study, the definition for SFSS in rats is still unclear (12). Therefore, in this study we used the term "small partial liver graft" for a 30% partial graft.…”

Section: Discussionmentioning

confidence: 99%

A Novel Organ Preservation for Small Partial Liver Transplantations in Rats: Venous Systemic Oxygen Persufflation With Nitric Oxide Gas

Yagi

Nagai

Kadaba

et al. 2013

American Journal of Transplantation

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The prognosis for recipients of small liver grafts is poor. The aim of this study was to determine the impact of venous systemic oxygen persufflation (VSOP) with nitric oxide (NO) gas for 30% partial liver preservation and transplantation in rats. After we determined optimal NO concentration as 40 ppm in vitro with the isolated perfused rat liver model, we assessed liver injury and regeneration in vivo at 1, 3, 24 and 168 h after transplantation in the following three groups after 3 h-cold storage (n = 20 per group): control group = static storage; VSOP group = oxygen persufflation and VSOP+NO group = oxygen with NO persufflation. The liver graft persufflation was achieved with medical gas via the suprahepatic vena cava; In comparison with control group after transplantation, VSOP+NO preservation (1) increased portal circulation, (2) reduced AST and ALT release, (3) upregulated hepatic endothelial NO synthase, (4) reduced hepatocyte and bileductule damage and (5) improved liver regeneration. These results suggest that gaseous oxygen with NO persufflation is a novel and safe preservation method for small partial liver grafts, not only alleviating graft injury but also improve liver regeneration after transplantation.

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Section: Discussionmentioning

confidence: 99%

A Novel Organ Preservation for Small Partial Liver Transplantations in Rats: Venous Systemic Oxygen Persufflation With Nitric Oxide Gas

Yagi

Nagai

Kadaba

et al. 2013

American Journal of Transplantation

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“…Animals were monitored daily to record body weight and to assess activity. During the observation time, the clinical condition of rats was observed and judged by using a semi-quantitative scoring system that was described previously [29]. Briefly, rats with normal activity, physiological position, no jaundice, and no signs of bleeding were regarded as healthy (); animals showing a weaker activity, hunched back position and/or signs of jaundice or bleeding were regarded as weak (); and animals with no spontaneous activity and lying position and signs of jaundice or bleeding were regarded as severely ill ().…”

Section: Methodsmentioning

confidence: 99%

How Does a Single Cell Know When the Liver Has Reached Its Correct Size?

et al. 2014

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The liver is a multi-functional organ that regulates major physiological processes and that possesses a remarkable regeneration capacity. After loss of functional liver mass the liver grows back to its original, individual size through hepatocyte proliferation and apoptosis. How does a single hepatocyte ‘know’ when the organ has grown to its final size? This work considers the initial growth phase of liver regeneration after partial hepatectomy in which the mass is restored. There are strong and valid arguments that the trigger of proliferation after partial hepatectomy is mediated through the portal blood flow. It remains unclear, if either or both the concentration of metabolites in the blood or the shear stress are crucial to hepatocyte proliferation and liver size control. A cell-based mathematical model is developed that helps discriminate the effects of these two potential triggers. Analysis of the mathematical model shows that a metabolic load and a hemodynamical hypothesis imply different feedback mechanisms at the cellular scale. The predictions of the developed mathematical model are compared to experimental data in rats. The assumption that hepatocytes are able to buffer the metabolic load leads to a robustness against short-term fluctuations of the trigger which can not be achieved with a purely hemodynamical trigger.

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“…2). 17 This last lobe was left unscathed. Arterial circulation and biliary duct branches were maintained in all cases.…”

Section: Methodological Designmentioning

confidence: 99%

Development of an Experimental Model of Portal Vein Ligation Associated With Parenchymal Transection (ALPPS) in Rats

Trenard

Moulin

Padín

et al. 2014

Cirugía Española (English Edition)

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Small-for-Size Syndrome in the Rat: Does Size or Technique Matter?

Cited by 24 publications

References 39 publications

A Novel Organ Preservation for Small Partial Liver Transplantations in Rats: Venous Systemic Oxygen Persufflation With Nitric Oxide Gas

A Novel Organ Preservation for Small Partial Liver Transplantations in Rats: Venous Systemic Oxygen Persufflation With Nitric Oxide Gas

How Does a Single Cell Know When the Liver Has Reached Its Correct Size?

Development of an Experimental Model of Portal Vein Ligation Associated With Parenchymal Transection (ALPPS) in Rats

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