Small genetic variation affecting mRNA isoforms associated with marbling and meat color in beef cattle

Muniz, Maria Malane Magalhães; Fonseca, Larissa Fernanda Simielli; Silva, Danielly Beraldo dos Santos; Magalhães, Ana Fabrícia Braga; Ferro, Jesus Aparecido; Chardulo, Luis Artur Loyola; Baldi, Fernando; Cánovas, Ángela; Albuquerque, Lúcia Galvão de

doi:10.1007/s10142-022-00844-w

Cited by 1 publication

(3 citation statements)

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“…As mentioned in the topic of WHC genes, this observation strengthens the notion of its influence in gene expression (Brown et al, 2013). study utilized the identical database employed by Muniz et al (2022), to investigate marbling traits. Color and marbling characteristics in Nellore beef cattle are probably influenced by overlapping genetic mechanisms, indicating the potential for simultaneous enhancement.…”

Section: Mhc Genessupporting

confidence: 65%

“…The JSP.1 gene was specifically associated with the meat color trait, with minor genetic variants located within its coding regions. Notably, in this study, JSP.1-204 exhibited differential expression in animals with desirable flesh color compared to those in the undesirable flesh color groups (Muniz et al, 2022). In the current study, the beta-e values exhibited variability in the expression of JSP.1, with three SNPs positively regulating gene expression and eight SNPs negatively regulating.…”

Section: Mhc Genesmentioning

confidence: 45%

“…Within these studies, specific mRNA isoforms were identified as potential candidates, including JSP.1-204, which was linked to both meat marbling and color traits. These regions feature minor genetic variants at their splice sites, which play a crucial role in determining the expression and functionality of these mRNA isoforms (Muniz et al, 2022).…”

Section: Mhc Genesmentioning

confidence: 99%

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Association of regulatory polymorphisms of gene expression with color phenotypes, water holding capacity, and pH of Nellore meat

Lima

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Association of regulatory polymorphisms of gene expression with color phenotypes, water holding capacity, and pH of Nellore meatThere is a growing demand for high-quality meat, necessitating the assessment of various traits influenced by intrinsic and extrinsic factors. These traits, governed by multiple genes and environmental influences, pose challenges in measurement due to their cost and the need for animal slaughter. Genomics emerges as a promising solution, as a tool to identify genetic markers regulating a significant portion of additive genetic variation in these traits. In this work, we aimed to identify expression quantitative trait loci (eQTLs) associated with meat quality phenotypes in Nellore cattle, including color, water-holding capacity, and pH. For that, we used a comprehensive single nucleotide polymorphisms (SNPs) panel of 553,581 markers, obtained from an imputed panel of SNPs encompassing genotypes from 778 progenies, DNA sequencing from 26 unrelated Nellore sires, and RNA sequencing data from muscle tissues of 192 progenies. The eQTL analysis, using genotypes of 192 animals, revealed 51,324 eQTLs. Subsequent genome-wide association studies (GWAS) with 374 animals identified 838 eQTLs associated with color, 172 with water-holding capacity, and three with pH. Integration with ATAC-Seq peaks identified 75 eQTLs associated with meat color and 24 associated with water-holding capacity in open chromatin regions. Enrichment analysis uncovered pathways such as immune response, antigen processing and presentation, and glutathione metabolism. Notably, most of genes regulated by eQTLs were associated with these pathways. This comprehensive approach identified putative candidate regulatory variants, and genes associated with meat quality, advancing our understanding of Bos indicus genetics.

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Section: Mhc Genessupporting

confidence: 65%

Section: Mhc Genesmentioning

confidence: 45%

Section: Mhc Genesmentioning

confidence: 99%

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