Small gold nanorods-loaded hybrid albumin nanoparticles with high photothermal efficacy for tumor ablation

Seo, Bohyung; Lim, Kyunghee; Kim, Sung Soo; Oh, Kyung Taek; Lee, Eun Seong; Choi, Han‐Gon; Shin, Beom Soo; Youn, Yu Seok

doi:10.1016/j.colsurfb.2019.03.068

Cited by 33 publications

(20 citation statements)

References 46 publications

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“…1 Photothermal agents convert light energy into heat, and gold nanorods and gold nanoclusters are known to be effective photothermal agents due to their localized surface plasmon resonances (LSPR). 2,3 However, the clinical use of gold nanoparticles is restricted due to significant tissue accumulation, poor glomerular filtration, and cetyl trimethylammonium bromide (CTAB)-based toxicity. [4][5][6] Recently, organic photothermal agents have gained great interest as a substitute for gold nanoparticles because these organic agents are considered to be safer and more biocompatible.…”

Section: Introductionmentioning

confidence: 99%

<p>Indocyanine Green and Curcumin Co-Loaded Nano-Fireball-Like Albumin Nanoparticles Based on Near-Infrared-Induced Hyperthermia for Tumor Ablation</p>

Pham¹,

Le²,

Kim³

et al. 2020

IJN

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Background: Indocyanine green (ICG) has received considerable interest as a biocompatible organic photothermal agent, and curcumin (Cur) is considered an attractive natural chemopreventive and chemotherapeutic compound. However, the in vivo applicability of ICG and Cur is significantly restricted by their poor ability to target tumors and their extremely low solubility. Materials and Methods: To address these problems, ICG/Cur-loaded albumin nanoparticles (ICG-BSA-Cur-NPs) based on the nab TM (nanoparticle albumin-bound) technology were applied to neuroblastomas in vivo. Results: The fabricated ICG-BSA-Cur-NPs were found to be spherical, ~150 nm in size and highly dispersible and stable in aqueous solution. Approximately 80% of the incorporated ICG and Cur were gradually released from the NPs over 48 h. All formulations of ICG-BSA-Cur-NPs (5~20 µg/mL) showed efficient hyperthermia profiles (up to 50-60°C within 5 min) in response to 808-nm NIR laser irradiation in vitro and in vivo. Notably, ICG-BSA-Cur-NPs illuminated with 808-nm laser irradiation (1.5 W/cm 2) showed excellent cytotoxicity toward N2a cells in vitro and undisputable antitumor efficacy in N2a-xenografted mice in vivo, compared to other tested sample groups (tumor volumes for PBS, BSA-Cur-NPs, free ICG, and ICG-BSA-Cur-NPs groups were 1408.6 ± 551.9, 1190.6 ± 343.6, 888.6 ± 566.2, and 103.0 ± 111.3 mm 3 , respectively). Conclusion: We demonstrate that these hyperthermal chemotherapeutic ICG-BSA-Cur-NPs have potential as a future brain tumor treatment.

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Section: Introductionmentioning

confidence: 99%

<p>Indocyanine Green and Curcumin Co-Loaded Nano-Fireball-Like Albumin Nanoparticles Based on Near-Infrared-Induced Hyperthermia for Tumor Ablation</p>

Pham¹,

Le²,

Kim³

et al. 2020

IJN

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“…Interest in gold nanorods (GnRs) as thermal agents is due to their ability to emit heat by absorbing near infrared light, on the basis of the phenomenon of localized surface plasmon resonance (LSPR) [18,19]. The GnR spectra exhibit two plasmon resonances: the transverse plasmon is the result of excitation across the nanorod diameter and the longitudinal plasmon is due to excitation along the nanorod length [20].…”

Section: Introductionmentioning

confidence: 99%

“…Investigations have shown the effectiveness of photothermal therapy using intratumorally and systemically injected GnRs in inducing cancer cell death [16,18,23,24]. However, research addressing the safety and toxicity of GnRs is still controversial [23,[25][26][27].…”

Section: Introductionmentioning

confidence: 99%

“…The surface chemistry of GnRs has been recently linked to toxicity in cultured cells and mice [23]. This could be attributed mainly to the surfactant used in the synthesis of GnRs, cetyltrimethylammonium bromide (CTAB), which has been associated with cytotoxicity at micromolar concentrations [18,28]. Hence, strategies to increase biocompatibility have been followed, such as functionalization, of the surfaces of GnRs with polymers, including poly(acrylic acid), poly(allylamine) hydrochloride, and poly(styrene)sultanate, or by exchanging CTAB with a less toxic ligand, such as mercaptohexadenoic acid or poly(ethylene)glycol [16,21,23,28].…”

Section: Introductionmentioning

confidence: 99%

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Potential of Polymeric Films Loaded with Gold Nanorods for Local Hyperthermia Applications

et al. 2020

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Current strategies for the treatment of superficial non-melanoma skin cancer (NMSC) lesions include topical imoquimod, 5-fluorouracil, and photodynamic therapy. Although these treatments are effective, burning pain, blistering, and dermatitis have been reported as frequent side effects, making these therapies far from ideal. Plasmonic materials have been investigated for the induction of hyperthermia and use in cancer treatment. In this sense, the effectiveness of intratumorally and systemically injected gold nanorods (GnRs) in inducing cancer cell death upon near-infrared light irradiation has been confirmed. However, the in vivo long-term toxicity of these particles has not yet been fully documented. In the present manuscript, GnRs were included in a crosslinked polymeric film, evaluating their mechanical, swelling, and adhesion properties; moreover, their ability to heat up neonatal porcine skin (such as a skin model) upon irradiation was tested. Inclusion of GnRs into the films did not affect mechanical or swelling properties. GnRs were not released after film swelling, as they remained entrapped in the polymeric network; moreover, films did not adhere to porcine skin, altogether showing the enhanced biocompatibility of the material. GnR-loaded films were able to heat up the skin model over 40 °C, confirming the potential of this system for non-invasive local hyperthermia applications.

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“…Photothermal therapy (PTT), where nanoparticles such as gold or iron oxide are exposed to near infra-red light (e.g., at 808 nm), absorbing this light and transforming it into localized heat through plasmonic effect, leading to the selective photothermal destruction of GBM cells at typical temperatures of 50-60 • C [35,[100][101][102][103].…”

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confidence: 99%

Nano-Therapies for Glioblastoma Treatment

Alphandéry

2020

Cancers

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Traditional anti-cancer treatments are inefficient against glioblastoma, which remains one of the deadliest and most aggressive cancers. Nano-drugs could help to improve this situation by enabling: (i) an increase of anti-glioblastoma multiforme (GBM) activity of chemo/gene therapeutic drugs, notably by an improved diffusion of these drugs through the blood brain barrier (BBB), (ii) the sensibilization of radio-resistant GBM tumor cells to radiotherapy, (iii) the removal by surgery of infiltrating GBM tumor cells, (iv) the restoration of an apoptotic mechanism of GBM cellular death, (v) the destruction of angiogenic blood vessels, (vi) the stimulation of anti-tumor immune cells, e.g., T cells, NK cells, and the neutralization of pro-tumoral immune cells, e.g., Treg cells, (vii) the local production of heat or radical oxygen species (ROS), and (viii) the controlled release/activation of anti-GBM drugs following the application of a stimulus. This review covers these different aspects.

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Small gold nanorods-loaded hybrid albumin nanoparticles with high photothermal efficacy for tumor ablation

Cited by 33 publications

References 46 publications

<p>Indocyanine Green and Curcumin Co-Loaded Nano-Fireball-Like Albumin Nanoparticles Based on Near-Infrared-Induced Hyperthermia for Tumor Ablation</p>

<p>Indocyanine Green and Curcumin Co-Loaded Nano-Fireball-Like Albumin Nanoparticles Based on Near-Infrared-Induced Hyperthermia for Tumor Ablation</p>

Potential of Polymeric Films Loaded with Gold Nanorods for Local Hyperthermia Applications

Nano-Therapies for Glioblastoma Treatment

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