Small intestinal bacterial overgrowth: could it be associated with chronic abdominal pain in children with allergic diseases?

Peña-Vélez, Rubén; Monjaráz, Erick Manuel Toro; Avelar-Rodríguez, David; Arellano, Karen Rubí Ignorosa; Mondragón, Flora Zárate; Cervantes-Bustamante, Roberto; Montijo-Barrios, Ericka; Cadena-León, José Francisco; Ramı́rez-Mayans, Jaime

doi:10.17235/reed.2019.6321/2019

Cited by 2 publications

(1 citation statement)

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“…A recent study has shown that SIBO was linked to allergic disease. 36 However, the study design was retrospective and involved a small number of subjects. Very few studies correlating SIBO and allergy have been reported.…”

Section: Discussionmentioning

confidence: 99%

Role of Glucose Breath Test for Small Intestinal Bacterial Overgrowth in Children and Adolescents With Functional Abdominal Pain Disorders in Korea

Liu

Paik

Kim

et al. 2022

J Neurogastroenterol Motil

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Background/AimsSmall intestinal bacterial overgrowth (SIBO) is expected in children and adolescents with functional abdominal pain disorders (FAPDs). This study is conducted to estimate the prevalence of SIBO and to investigate the role of SIBO in children and adolescents with FAPDs. MethodsThis prospective study enrolled children with FAPDs fulfilling the Rome IV criteria. A hydrogen-methane glucose breath test was used to diagnose SIBO. A survey of bowel symptoms using questionnaires, birth history, types of feeding, and the presence of allergy was conducted. ResultsSixty-eight children and adolescents (range, 6-17 years; median, 12.5 years) were enrolled. SIBO was detected in 14 patients (20.6%). Age (≥ 12 years) (P < 0.003) and loose stool (P = 0.048) were significantly more common in children with SIBO than in children without SIBO. However, the history of allergies (P = 0.031) was less common in children with SIBO than those without SIBO. No significant differences were observed in other demographic findings. In multivariate analysis, age (≥ 12 years) was the independent factor predicting SIBO in children with FAPDs. ConclusionsSIBO is not uncommon in children and adolescents with FAPDs. Among children aged above 12 years and diagnosed with FAPDs, SIBO is a suspected clinical target for treatment to relieve intestinal symptoms. A further study to investigate the association between intestinal bacteria and history of allergy is needed.

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Section: Discussionmentioning

confidence: 99%