Small intestinal CMV disease detected by capsule endoscopy after allogeneic hematopoietic SCT

Kakugawa, Yasuo; Sw, Kim; Takizawa, Kiyohiro; Kikuchi, Takayoshi; Fujieda, Atsushi; Waki, Fusako; Fukuda, Takahiro; Saito, Yutaka; Shimoda, Tadakazu; Takaue, Yoichi; Saito, Daizo

doi:10.1038/bmt.2008.154

Cited by 10 publications

(7 citation statements)

References 8 publications

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“…Therefore, endoscopy allows direct vision of the mucosa of the alimentary tract, identification of ulcerations and lumen narrowing, and obtaining biopsy specimens for histopathological study . Especially for suspicious small intestine disease, capsule endoscopy may aid in suggesting the diagnosis, but false‐negative results can occur because it is impossible to obtain biopsies . Currently, several reports describe the value of modern alternative imaging methods in the diagnosis of terminal ileitis, such as PET‐CT with 18‐FDG and magnetic resonance enterography .…”

Section: Discussionmentioning

confidence: 99%

Small bowel obstruction caused by inflammatory cytomegalovirus tumor in a renal transplant recipient: report of a rare case and review of the literature

Papadimitriou

Koukoulaki

Vardas

et al. 2012

Transplant Infectious Dis

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Cytomegalovirus (CMV) infection in renal transplant recipients can present as asymptomatic viremia or CMV syndrome or, in more severe cases, as tissue-invasive disease. CMV enteritis, a common manifestation of CMV invasive disease, usually presents with fever, abdominal pain, anorexia, nausea, and diarrhea, and can be rarely complicated by colon perforation, hemorrhage, or megacolon. CMV infection occurs primarily in the first 6 months post transplantation, when immunosuppression is more intense. We describe the case of a female renal transplant recipient with small bowel obstruction caused by CMV disease 7 years post renal transplantation. The patient presented with diarrhea and abdominal pain. Because of elevated CMV viral load, she was initially treated with antiviral therapy with transient response. Endoscopy and imaging tests showed obstruction of the terminal ileum and, subsequently, the patient underwent exploratory laparotomy when a right hemicolectomy was performed. Biopsy results confirmed the diagnosis of CMV enteritis. Epidemiologic characteristics, clinical presentation, diagnostic workup, therapeutic options, and morbidity-mortality rates of CMV infection/disease, in renal transplant recipients, are reviewed.

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Section: Discussionmentioning

confidence: 99%

Small bowel obstruction caused by inflammatory cytomegalovirus tumor in a renal transplant recipient: report of a rare case and review of the literature

Papadimitriou

Koukoulaki

Vardas

et al. 2012

Transplant Infectious Dis

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“…After primary infection and persistence, it may be reactivated. Infection often remains asymptomatic but severe disease may occur in immunosuppression, e. g. in malignant diseases, pharmacological treatment or Acquired Immunodeficiency Syndrome (AIDS) [336,337]. It may affect all portions of the gastrointestinal tract, sometimes causing mid-gastrointestinal bleeding, obstruction or perforation [338,339].…”

Section: Cytomegalovirus Enteritismentioning

confidence: 99%

Small Bowel Capsule Endoscopy

Rahman

Patel

Rondonotti³

et al. 2014

Handbook of Capsule Endoscopy

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“…However, biopsies cannot be performed during WCE, and despite the apparently high NPV in these studies, they are based on a very low number of patients and EGD with biopsies remains indispensable. Furthermore, WCE probably lacks specificity given that erosion and ulceration were reported on WCE performed in patients with CMV diseases after allo-SCT [52, 57]. Overall, WCE realization can be useful in patients with GI acute GVHD symptoms and normal EGD.…”

Section: Endoscopic Examinationmentioning

confidence: 99%

New Insight for the Diagnosis of Gastrointestinal Acute Graft-versus-Host Disease

Malard

Mohty

2014

Mediators of Inflammation

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Allogeneic stem cell transplantation (allo-SCT) is a curative therapy for different life-threatening malignant and nonmalignant hematologic disorders. Graft-versus-host disease (GVHD) remains a major source of morbidity and mortality following allo-SCT, which limits the use of this treatment in a broader spectrum of patients. Early diagnostic of GVHD is essential to initiate treatment as soon as possible. Unfortunately, the diagnosis of GVHD may be difficult to establish, because of the nonspecific nature of the associated symptoms and of the numerous differential diagnosis. This is particularly true regarding gastrointestinal (GI) acute GVHD. In the recent years many progress has been made in medical imaging test and endoscopic techniques. The interest of these different techniques in the diagnosis of GI acute GVHD has been evaluated in several studies. With this background we review the contributions, limitations, and future prospect of these techniques in the diagnosis of GI acute GVHD.

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Small intestinal CMV disease detected by capsule endoscopy after allogeneic hematopoietic SCT

Abstract: Figure 1 Total colonoscopy revealed a single ulceration (a) with several erosions in the ascending colon. Capsule endoscopy also revealed a single ulceration (b) with several erosions in the jejunum very similar to the one found in the ascending colon.

Cited by 10 publications

References 8 publications

Small bowel obstruction caused by inflammatory cytomegalovirus tumor in a renal transplant recipient: report of a rare case and review of the literature

Small bowel obstruction caused by inflammatory cytomegalovirus tumor in a renal transplant recipient: report of a rare case and review of the literature

Small Bowel Capsule Endoscopy

New Insight for the Diagnosis of Gastrointestinal Acute Graft-versus-Host Disease

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