Small Intestinal Ganglioneuromatosis in a Dog

Paris, J; McCandlish, IA; Schwarz, Tobias; Simpson, James; Smith, Sionagh

doi:10.1016/j.jcpa.2012.07.002

Cited by 13 publications

(31 citation statements)

References 26 publications

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Section: Introductionmentioning

confidence: 99%

“…Ganglioneuromatosis has been described in few dogs in the intestinal tract [5][6][7][8] and in the wall of the gallbladder [9]. It has so far been mostly reported in puppies and juveniles [5][6][7], rarely in adult dogs [8,9]. Reported clinical signs of ganglioneuromatosis include persistent diarrhea, intermittent vomiting, poor appetite, depression and poor body condition in small intestinal ganglioneuromatosis [6,8] and tenesmus, hematochezia and rectal prolapse in colorectal ganglioneuromatosis [5,7].…”

Section: Introductionmentioning

confidence: 99%

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Small Intestinal Ganglioneuromatosis Accompanied by an Ulcer in a 13-Year Old Dog

2020

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Ganglioneuromatosis is a rare disorder characterized by hyperplasia of intestinal ganglia including myenteric plexus and enteric nerve fibers. This disorder is generally described in children, but sporadic cases have also been described in adults. Most human cases arise in the colon and rectum. The disorder has also been described in dogs, mostly juveniles, but rarely in mature dogs with the oldest dog reported with this change being 9 years old.We report the first case in an older dog from Croatia. A 13-year old female, mixed-breed dog had a history of diarrhea and weight loss. Ultrasound revealed focally-extensive markedly thickened small intestine. The changed part of the intestine, measuring 7 mm x 20 mm, was removed on laparotomy and delivered for histopathologic examination. Grossly, the intestine showed circumferential expansion of the intestinal wall, which was whitish in color. Microscopic findings included diffuse hyperplasia of the myenteric and submucous plexus. Focally in the affected tissue a subacute ulcer was evident, which was probably not the cause of intestinal signs, as it presented a localized lesion, while ganglioneuromatosis was a diffuse change in the affected tissue.So far, ganglioneuromatosis was reported in young dogs, rarely in adult dogs. Our report shows that ganglioneuromatosis can also be encountered in older dogs. Although the lesion presents a rare finding, it should be listed as a differential diagnosis in dogs where infectious and neoplastic etiology has been ruled out as cause of diarrhea.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Small Intestinal Ganglioneuromatosis Accompanied by an Ulcer in a 13-Year Old Dog

2020

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“…Total excision of the descending duodenum with extrahepatic biliary derivation has been associated with high mortality rates 12. Of the four previously reported cases of intestinal GNM in dogs, only one had a successful outcome after surgery 4. For this dog, GNM was localised to the jejunum and was subsequently treated by segmental jejunal enterectomy.…”

Section: Discussionmentioning

confidence: 93%

Duodenal ganglioneuromatosis causing common bile duct obstruction in a dog

Deprez

Grand

Harran

2019

Vet Record Case Reports

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A 3-year-old intact female labrador retriever dog was presented for anorexia, weight loss and vomiting. Abdominal ultrasonography revealed a mass of the descending duodenum involving the major duodenal papilla with loss of the normal intestinal wall layering. The distal part of the common bile duct was circumferentially thickened obliterating its lumen and causing extrahepatic biliary obstruction. Exploratory laparotomy was undertaken, total descending duodenum excision with gastrojejunostomy, cholecystojejunostomy and pancreaticojejunostomy procedures were performed. The dog died 3 days postoperatively. Histopathological and immunohistochemistry examinations of the specimens from the duodenectomy demonstrated multinodular to diffuse intestinal ganglioneuromatosis. This is the first reported case of an intestinal ganglioneuromatosis, a rare hyperplastic proliferation of ganglion cells and nerves of the enteric autonomic nervous system, involving the duodenum and causing extrahepatic biliary obstruction.

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“…Ganglioneuromas are previously reported in dogs, cats, pigs, and goats [ 4 ]. In dogs, ganglioneuromas have been reported to occur in the jejunum [ 13 ], rectum [ 14 ], skin of the thoracic area [ 3 ], and urinary bladder [ 15 ]. Ganglioneuroblastomas have been reported in the olfactory epithelium [ 10 ], thoracic area [ 16 ] and oral mucosa [ 12 ].…”

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confidence: 99%

Lingual ganglioneuroma in a dog

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Yonemaru

Hirata

et al. 2018

The Journal of Veterinary Medical Science

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A mass was found at the base of the dorsum linguae of a male 11-year-old Labrador retriever. The tumor comprised of ganglion cells and Schwannian cells with Verocay bodies. The ganglion cells were positive for neuron-specific enolase, S-100, nerve growth factor receptor, and beta III tubulin. The Schwannian cells were positive for neuron-specific enolase, S-100, nerve growth factor receptor, and glial fibrillary acidic protein. The lingual mass was diagnosed as a ganglioneuroma. To our knowledge, there has been no previous report of a lingual ganglioneuroma in a dog.

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Small Intestinal Ganglioneuromatosis in a Dog

Cited by 13 publications

References 26 publications

Small Intestinal Ganglioneuromatosis Accompanied by an Ulcer in a 13-Year Old Dog

Small Intestinal Ganglioneuromatosis Accompanied by an Ulcer in a 13-Year Old Dog

Duodenal ganglioneuromatosis causing common bile duct obstruction in a dog

Lingual ganglioneuroma in a dog

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