Fix a degree d projective curve X⊂double-struckPr over an algebraically closed field K. Let U⊂(double-struckPr)∗ be a dense open subvariety such that every hyperplane H∈U intersects X in d smooth points. Varying H∈U produces the monodromy action φ:π1étfalse(Ufalse)→Sd. Let GX≔imfalse(φfalse). The permutation group GX is called the sectional monodromy group of X. In characteristic 0, GX is always the full symmetric group, but sectional monodromy groups in characteristic p can be smaller. For a large class of space curves (r⩾3), we classify all possibilities for the sectional monodromy group G as well as the curves with GX=G. We apply similar methods to study a particular family of rational curves in P2, which enables us to answer an old question about Galois groups of generic trinomials.