Small-molecule natural plants for reversing liver fibrosis based on modulation of hepatic stellate cells activation: An update

Zheng, Yu; Xie, Long; Yang, Dan; Luo, Kaipei; Li, Xiaofang

doi:10.1016/j.phymed.2023.154721

Cited by 13 publications

(4 citation statements)

References 179 publications

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“…Hepatic stellate cells (HSC) are undifferentiated cells that play a role in liver regeneration by differentiating into endothelial cells in response to liver damage [ 205 ]. HSC activation is a driver of liver fibrosis [ 206 ], a critical step in developing cirrhosis [ 207 , 208 ]. As activated HSCs develop into myofibroblasts, they deposit excess extracellular matrix which results in the production of scar tissue contributing to liver fibrosis [ 206 ].…”

Section: M6a and Liver Physiologymentioning

confidence: 99%

“…HSC activation is a driver of liver fibrosis [ 206 ], a critical step in developing cirrhosis [ 207 , 208 ]. As activated HSCs develop into myofibroblasts, they deposit excess extracellular matrix which results in the production of scar tissue contributing to liver fibrosis [ 206 ]. Recent studies have identified potential mRNA targets of m 6 A and related pathways using in vivo and in vitro models of HSC activation [ 209 , 210 , 211 ].…”

Section: M6a and Liver Physiologymentioning

confidence: 99%

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Changes in m6A in Steatotic Liver Disease

Petri,

Cave,

Klinge

2023

Genes

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Fatty liver disease is one of the major causes of morbidity and mortality worldwide. Fatty liver includes non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), now replaced by a consensus group as metabolic dysfunction-associated steatotic liver disease (MASLD). While excess nutrition and obesity are major contributors to fatty liver, the underlying mechanisms remain largely unknown and therapeutic interventions are limited. Reversible chemical modifications in RNA are newly recognized critical regulators controlling post-transcriptional gene expression. Among these modifications, N6-methyladenosine (m6A) is the most abundant and regulates transcript abundance in fatty liver disease. Modulation of m6A by readers, writers, and erasers (RWE) impacts mRNA processing, translation, nuclear export, localization, and degradation. While many studies focus on m6A RWE expression in human liver pathologies, limitations of technology and bioinformatic methods to detect m6A present challenges in understanding the epitranscriptomic mechanisms driving fatty liver disease progression. In this review, we summarize the RWE of m6A and current methods of detecting m6A in specific genes associated with fatty liver disease.

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Section: M6a and Liver Physiologymentioning

confidence: 99%

Section: M6a and Liver Physiologymentioning

confidence: 99%

Changes in m6A in Steatotic Liver Disease

Petri,

Cave,

Klinge

2023

Genes

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“…By introducing antiin ammatory agents based on small natural molecules, the immune regulation ability of rhubarb acidbased hydrogels can be achieved. PUE, derived from Pueraria, possesses the anti-in ammatory, antioxidant defense and oxidative stress-relieving properties of Pueraria [25][26][27] , and is used in the treatment of myocardial infarction and diabetes [28] . This work is predicated on the two small natural molecules' complementary physical and e cacious properties.…”

Section: Introductionmentioning

confidence: 99%

Puerarin-Containing Rhein-Crosslinked Hydrogel for Antibacterial and Anti-Inflammatory Wound Dressings

Zheng,

Li,

et al. 2024

Preprint

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“…used in the treatment of cardiovascular and cerebrovascular diseases [17][18][19]. It is reported that TMP has multiple pharmacological effects, including epilepsy [20], liver fibrosis [21], and obstetrical and gynecological diseases [22]. However, TMP is easily sublimated and hygroscopic in physicochemical properties [23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

New Cocrystals of Ligustrazine: Enhancing Hygroscopicity and Stability

Xie,

Gong,

Tao

et al. 2024

Molecules

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Ligustrazine (TMP) is the main active ingredient extracted from Rhizoma Chuanxiong, which is used in the treatment of cardiovascular and cerebrovascular diseases, with the drawback of being unstable and readily sublimated. Cocrystal technology is an effective method to improve the stability of TMP. Three benzoic acid compounds including P-aminobenzoic acid (PABA), 3-Aminobenzoic acid (MABA), and 3,5-Dinitrobenzoic acid (DNBA) were chosen for co-crystallization with TMP. Three novel cocrystals were obtained, including TMP-PABA (1:2), TMP-MABA (1.5:1), and TMP-DNBA (0.5:1). Hygroscopicity was characterized by the dynamic vapor sorption (DVS) method. Three cocrystals significantly improved the hygroscopicity stability, and the mass change in TMP decreased from 25% to 1.64% (TMP-PABA), 0.12% (TMP-MABA), and 0.03% (TMP-DNBA) at 90% relative humidity. The melting points of the three cocrystals were all higher than TMP, among which the TMP-DNBA cocrystal had the highest melting point and showed the best stability in reducing hygroscopicity. Crystal structure analysis shows that the mesh-like structure formed by the O-H…N hydrogen bond in the TMP-DNBA cocrystal was the reason for improving the stability of TMP.

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Small-molecule natural plants for reversing liver fibrosis based on modulation of hepatic stellate cells activation: An update

Cited by 13 publications

References 179 publications

Changes in m6A in Steatotic Liver Disease

Changes in m6A in Steatotic Liver Disease

Puerarin-Containing Rhein-Crosslinked Hydrogel for Antibacterial and Anti-Inflammatory Wound Dressings

New Cocrystals of Ligustrazine: Enhancing Hygroscopicity and Stability

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