Small phenolic and indolic gut-dependent molecules in the primate central nervous system: levels vs. bioactivity

Jaskiw, George E.; Xu, Dake; Obrenovich, Mark E.; Donskey, Curtis J.

doi:10.1007/s11306-021-01866-4

Cited by 3 publications

(1 citation statement)

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“…The neuroinflammation is the primary cause of neurodegenerative disorders. An effective brain defence mechanism against dangerous microorganisms and injured tissue is the activation of microglia and astrocytes (Gul & Hamann, 2005; Jaskiw et al., 2022). The alkaloid Berberine, a bioactive compound in Huang Lian, a traditional Chinese medicine, also plays a neuroprotective role (Chen et al., 2023) (Figure 7).…”

Section: Therapeutic Approaches Targeting Autophagy and Proteostasismentioning

confidence: 99%

Role of autophagy and proteostasis in neurodegenerative diseases: Exploring the therapeutic interventions

Panwar,

Uniyal,

Kukreti

et al. 2024

Chem Biol Drug Des

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Neurodegenerative disorders are devastating disorders characterized by gradual loss of neurons and cognition or mobility impairment. The common pathological features of these diseases are associated with the accumulation of misfolded or aggregation of proteins. The pivotal roles of autophagy and proteostasis in maintaining cellular health and preventing the accumulation of misfolded proteins, which are associated with neurodegenerative diseases like Huntington's disease (HD), Alzheimer's disease (AD), and Parkinson's disease (PD). This article presents an in‐depth examination of the interplay between autophagy and proteostasis, highlighting how these processes cooperatively contribute to cellular homeostasis and prevent pathogenic protein aggregate accumulation. Furthermore, the review emphasises the potential therapeutic implications of targeting autophagy and proteostasis to mitigate neurodegenerative diseases. While advancements in research hold promise for developing novel treatments, the article also addresses the challenges and complexities associated with modulating these intricate cellular pathways. Ultimately, advancing understanding of the underlying mechanism of autophagy and proteostasis in neurodegenerative disorders provides valuable insights into potential therapeutic avenues and future research directions.

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Section: Therapeutic Approaches Targeting Autophagy and Proteostasismentioning

confidence: 99%