Smaller hippocampal volumes predict lower antidepressant response/remission rates in depressed patients: A meta-analysis

Colle, Romain; Dupong, Irène; Colliot, Olivier; Deflesselle, Éric; Hardy, Patrick; Falissard, Bruno; Ducreux, D.; Chupin, Marie; Corruble, Emmanuelle

doi:10.1080/15622975.2016.1208840

Cited by 38 publications

(26 citation statements)

References 24 publications

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“…Moreover, a similar correlation was observed in patients receiving traditional antidepressants: larger pretreatment hippocampal volumes predicted a better antidepressant response and recovery 42 . One potential explanation for this is that patients with larger hippocampal volumes have a higher intrinsic "restorative" capacity of neuronal plasticity; thus, they could tend to achieve more synergistic effects with the antidepressant treatment 42 . Also note that the present study sample was relatively young, with a short duration of illness, mixed (TRD and suicidal patients) on a high frequency of antipsychotic medicines (63.6%) as compared to other reports of TRD with ketamine.…”

Section: Discussionsupporting

confidence: 66%

Volumetric changes in subcortical structures following repeated ketamine treatment in patients with major depressive disorder: a longitudinal analysis

Zhou

Liu

et al. 2020

Transl Psychiatry

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Abnormal subcortical structures have been associated with major depressive disorder (MDD) and could be reversed by antidepressant treatment. To date no study has examined the relationship between subcortical volumes and repeated ketamine treatment. The current study investigated volume changes in specific subcortical structures and hippocampal subfields after six ketamine infusions. Forty-four patients with MDD received six subanesthetic dose infusions of ketamine. Depressive symptoms were assessed and magnetic resonance imaging scans were performed before and after six ketamine infusions. FreeSurfer software was used to process the T1 images and analyze the volumes of the subcortical regions and hippocampal subfields. After six ketamine infusions, increases were observed in the volumes of the left amygdala; the right hippocampus; the cornu ammonis 4 body, granule cell and molecular layer of the dentate gyrus body in the left hippocampus; and the cornu ammonis 4 head and molecular layer head in the right hippocampus. Positive correlations were found between symptom improvement and the pretreatment volumes of the right thalamus (r = 0.501; P = 0.001) and left subiculum head of the hippocampus (r = 0.471; P = 0.002), and changes in the volumes of the left amygdala (r = −0.452; P = 0.003) and the left cornu ammonis 4 body (r = −0.537; P < 0.001). Our findings provided evidence for critical roles of the amygdala and specific hippocampal subfields in the antidepressant effect of repeated ketamine treatment. Relatively larger volumes in right thalamus and left subiculum head in the hippocampus can predict a superior clinical outcome of ketamine treatment in MDD patients.

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Section: Discussionsupporting

confidence: 66%

Volumetric changes in subcortical structures following repeated ketamine treatment in patients with major depressive disorder: a longitudinal analysis

Zhou

Liu

et al. 2020

Transl Psychiatry

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“…53,56,58 Finally, smaller hippocampal volume appears to predict poorer response to antidepressant treatment. 59 We found no differences in pre-DBS hippocampal volume between responders and nonresponders to SCG DBS in our population of TRD patients. It is possible that the similar proportion of patients with a family history of depression, similar duration of illness and similar duration of antidepressant therapy (see Table 1) may have attenuated any subtle inter-group pre-DBS variability in hippocampal volume.…”

Section: Cortical and Subcortical Volumetric Predictors Of Response Tcontrasting

confidence: 53%

Neuroanatomical predictors of response to subcallosal cingulate deep brain stimulation for treatment-resistant depression

Sankar

Chakravarty

Jawa

et al. 2020

jpn

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Background: Deep brain stimulation targeting the subcallosal cingulate gyrus (SCG DBS) improves the symptoms of treatment-resistant depression in some patients, but not in others. We hypothesized that there are pre-existing structural brain differences between responders and nonresponders to SCG DBS, detectable using structural MRI. Methods: We studied preoperative, T 1 -weighted MRI scans of 27 patients treated with SCG DBS from 2003 to 2011. Responders (n = 15) were patients with a > 50% improvement in Hamilton Rating Scale for Depression score following 12 months of SCG DBS. Preoperative subcallosal cingulate gyrus grey matter volume was obtained using manual segmentation by a trained observer blinded to patient identity. Volumes of hippocampus, thalamus, amygdala, whole-brain cortical grey matter and white matter volume were obtained using automated techniques. Results: Preoperative subcallosal cingulate gyrus, thalamic and amygdalar volumes were significantly larger in patients who went on to respond to SCG-DBS. Hippocampal volume did not differ between groups. Cortical grey matter volume was significantly smaller in responders, and cortical grey matter:white matter ratio distinguished between responders and nonresponders with high sensitivity and specificity. Limitations: Normalization by intracranial volume nullified some between-group differences in volumetric measures. Conclusion: There are structural brain differences between patients with treatment-resistant depression who respond to SCG DBS and those who do not. Specifically, the structural integrity of the subcallosal cingulate gyrus target region and its connected subcortical areas, and variations in cortical volume across the entire brain, appear to be important determinants of response. Structural MRI shows promise as a biomarker in deep brain stimulation for depression, and may play a role in refining patient selection for future trials.Predictors of response to deep brain stimulation for depression J Psychiatry Neurosci 2020;45(1) 53 Rizvi); and the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States (Mayberg).

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“…While we observed a small effect size for the association between severity of lifetime stress and HV, we observed a medium effect size for the association between stress severity in early life and HV (Cohen, ). Our findings have important clinical implications given that smaller HV has been prospectively linked to a number of outcomes, including vulnerability to psychopathology following trauma (Gilbertson, Shenton, Ciszewski, Kasai, Lasko, Orr, & Pitman, ), poorer antidepressant treatment response (Colle, Dupong, Colliot, Deflesselle, Hardy, Falissard, & Corruble, ), and memory deficits (Zheng, Li, Xiao, He, Zhang, & Li, ).…”

Section: Discussionmentioning

confidence: 79%

Evidence for a sensitive period in the effects of early life stress on hippocampal volume

Humphreys

King

Sacchet

et al. 2018

Developmental Science

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Exposure to stress has been causally linked to changes in hippocampal volume (HV). Given that the hippocampus undergoes rapid changes in the first years of life, stressful experiences during this period may be particularly important in understanding individual differences in the development of the hippocampus. One hundred seventy‐eight early adolescents (ages 9–13 years; 43% male) were interviewed regarding exposure to and age of onset of experiences of stress; the severity of each stressful event was rated by an objective panel. All participants underwent structural magnetic resonance imaging, from which HVs were automatically segmented. Without considering the age of onset for stressful experiences, there was a small but statistically significant negative association of stress severity with bilateral HV. When considering the age of onset, there was a moderate and significant negative association between stress severity during early childhood (through 5 years of age) and HV; there was no association between stress severity during later childhood (age 6 years and older) and HV. We provide evidence of a sensitive period through 5 years of age for the effects of life stress on HV in adolescence. It will be important in future research to elucidate how reduced HV stemming from early life stress may contribute to stress‐related health outcomes.

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Smaller hippocampal volumes predict lower antidepressant response/remission rates in depressed patients: A meta-analysis

Abstract: In depressed patients treated with antidepressant drugs, smaller hippocampal volumes predict lower response/remission rates.

Cited by 38 publications

References 24 publications

Volumetric changes in subcortical structures following repeated ketamine treatment in patients with major depressive disorder: a longitudinal analysis

Volumetric changes in subcortical structures following repeated ketamine treatment in patients with major depressive disorder: a longitudinal analysis

Neuroanatomical predictors of response to subcallosal cingulate deep brain stimulation for treatment-resistant depression

Evidence for a sensitive period in the effects of early life stress on hippocampal volume

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