Smaller volumes of caudate nuclei in prepubertal children with ADHD: Impact of age

Carrey, Normand; Bernier, Denise; Emms, Mandy; Gunde, Eva; Sparkes, Sandra J.; MacMaster, Frank P.; Rusak, Benjamin

doi:10.1016/j.jpsychires.2012.04.025

Cited by 18 publications

(18 citation statements)

References 40 publications

(56 reference statements)

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“…A previous study has shown that caudate volume differences are more pronounced in children than in adolescents with differences disappearing by mid-adolescence (Castellanos et al, 2002). More recently, (Carrey et al, 2012) showed that caudate volume differences were only found in prepubertal ADHD children. This is in contrast to a large cross-sectional study by Greven et al (2015) who reported significantly smaller total caudate volumes in a young ADHD group (≤ 15 years) and significantly larger total caudate volumes in an older group (> 22 years) but no differences relative to control participants in the middle group (16 -22 years).…”

Section: Discussionmentioning

confidence: 92%

“…Despite the heterogeneity, several previous studies and subsequent meta-analyses have reported volume reductions of the caudate nucleus in children with ADHD (Frodl and Skokauskas, 2012;Nakao et al, 2011), which seem to normalise with increasing age (Carrey et al, 2012;Nakao et al, 2011). Caudate asymmetry may also be different in individuals with ADHD (Castellanos et al, 1994) with abnormalities more often observed on the right (Almeida Montes et al, 2010;Filipek et al, 1997;Tremols et al, 2008;Valera et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Global and local grey matter reductions in boys with ADHD combined type and ADHD inattentive type

Vilgis

Sun

Chen

et al. 2016

Psychiatry Research: Neuroimaging

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Global and local grey matter reductions in boys with ADHD combined type and ADHD inattentive type

Vilgis

Sun

Chen

et al. 2016

Psychiatry Research: Neuroimaging

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“…Manual tracing is preferable to automated methods for the study of smaller subcortical structures [50] and in subjects with developing brains as suggested by Carrey et al [4]. Two raters (SW and HC) blind to the identity and risk group membership traced the volumes of the caudate and intracranial volume (ICV).…”

Section: Methodsmentioning

confidence: 99%

“…Among the most prominent of these are studies of individuals with externalizing disorders of childhood and adolescence (Attention Deficit Hyperactivity Disorder [ADHD], Conduct and Oppositional disorders). Neuroimaging studies of children with ADHD [4-6] and Oppositional Defiant Disorder (ODD)/Conduct Disorder [7,8] have documented structural alterations of the cau-date nucleus.…”

Section: Introductionmentioning

confidence: 99%

Caudate Volume in Offspring at Ultra High Risk for Alcohol Dependence: COMT Val158Met, DRD2, Externalizing Disorders, and Working Memory*

Hill¹,

Lichenstein²,

Wang³

et al. 2013

AMI

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Background There is emerging evidence that the increased susceptibility to developing alcohol and substance use disorders in those with a family history of Alcohol Dependence (AD) may be related to structural differences in brain circuits that influence the salience of rewards or modify the efficiency of information processing. Externalizing disorders of childhood including Attention Deficit Hyperactivity Disorder, Conduct and Oppositional Disorders are a prominent feature of those with a positive family history. The caudate nuclei have been implicated in both the salience of rewards and in the pathophysiology of alcohol dependence and these often antecedent childhood disorders. Methods Adolescent/young adult high and low-risk for AD offspring (N = 130) were studied using magnetic resonance imaging. Volumes of the caudate nucleus were obtained using manual tracing with BRAINS2 software and neuropsychological functioning determined. Childhood disorders were assessed as part of a long-term longitudinal follow-up that includes young adult assessment. Dopaminergic variation was assessed using genotypic variation in the catechol-O-methyltransferase (COMT) and DRD2 genes. Results High-risk subjects showed poorer Working Memory functioning. Cau-date volume did not differ between high and low-risk subjects, but those with externalizing disorders of childhood showed reduced caudate volume. Variation in COMT and DRD2 genes was associated with Working Memory performance and caudate volume. Conclusions Caudate volume is reduced in association with externalizing disorders of childhood/adolescence. Working Memory deficits appear in familial high-risk offspring and those with externalizing disorders of childhood. The dopaminergic system appears to be involved in both working memory performance and externalizing disorders of childhood.

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“…They emphasize the reduced volume of the basal ganglia, especially the lentiform nucleus (globus pallidus and putamen) (Ellison-Wright et al 2008; Nakao et al 2011) and the caudate (Ellison-Wright et al 2008; Frodl and Skokauskas 2012; Nakao et al 2011; Valera et al 2007) seen in ADHD patients. More specifically, the abnormal size of the caudate seems to depend on age and has been reported to be most prominent in prepubescents with ADHD (Carrey et al 2012; Castellanos et al 2002; Mahone et al 2011). Furthermore, partial normalization of the basal ganglia volume was found when ADHD patients were treated with stimulant medication (Nakao et al 2011).…”

Section: Structural and Functional Abnormalities In Ocd And Adhdmentioning

confidence: 99%

The neurobiological link between OCD and ADHD

Brem

Grünblatt

Drechsler

et al. 2014

ADHD Atten Def Hyp Disord

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Obsessive compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD) are two of the most common neuropsychiatric diseases in paediatric populations. The high comorbidity of ADHD and OCD with each other, especially of ADHD in paediatric OCD, is well described. OCD and ADHD often follow a chronic course with persistent rates of at least 40–50 %. Family studies showed high heritability in ADHD and OCD, and some genetic findings showed similar variants for both disorders of the same pathogenetic mechanisms, whereas other genetic findings may differentiate between ADHD and OCD. Neuropsychological and neuroimaging studies suggest that partly similar executive functions are affected in both disorders. The deficits in the corresponding brain networks may be responsible for the perseverative, compulsive symptoms in OCD but also for the disinhibited and impulsive symptoms characterizing ADHD. This article reviews the current literature of neuroimaging, neurochemical circuitry, neuropsychological and genetic findings considering similarities as well as differences between OCD and ADHD.

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Smaller volumes of caudate nuclei in prepubertal children with ADHD: Impact of age

Cited by 18 publications

References 40 publications

Global and local grey matter reductions in boys with ADHD combined type and ADHD inattentive type

Global and local grey matter reductions in boys with ADHD combined type and ADHD inattentive type

Caudate Volume in Offspring at Ultra High Risk for Alcohol Dependence: COMT Val158Met, DRD2, Externalizing Disorders, and Working Memory*

The neurobiological link between OCD and ADHD

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