'Smart' biomaterials and osteoinductivity

Yuan, Huipin; Fernandes, Hugo; Habibović, Pamela; Boer, Jan de; Barradas, Ana; Ruiter, Ad de; Walsh, William R.; Blitterswijk, Clemens A. van; Bruijn, Joost D. de

doi:10.1038/nrrheum.2010.210-c1

Cited by 17 publications

(20 citation statements)

References 2 publications

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“…However, the appreciation of the fact that some of these materials possess intrinsic osteoinductivity by broad audience needs a paradigm shift that can only be achieved with complete comprehension of the mechanism behind this phenomenon (Yuan et al, 2011). And although the mechanism is still not fully understood, in this review we have shown that the knowledge of material properties relevant for osteoinduction has tremendously increased in the past decade, despite the limitations of available models to test osteoinductivity.…”

Section: Future Perspectivesmentioning

confidence: 93%

Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms

Barradas

Yuan²,

Blitterswijk³

et al. 2011

eCM

446

365

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In the past thirty years, a number of biomaterials have shown the ability to induce bone formation when implanted at heterotopic sites, an ability known as osteoinduction. Such biomaterials -osteoinductive biomaterials -hold great potential for the development of new therapies in bone regeneration. Although a variety of well characterised osteoinductive biomaterials have so far been reported in the literature, scientists still lack fundamental understanding of the biological mechanism underlying the phenomenon by which they induce bone formation. This is further complicated by the observations that larger animal models are required for research, since limited, if any, bone induction by biomaterials is observed in smaller animals, including particularly rodents. Besides interspecies variation, variations among individuals of the same species have been observed. Furthermore, comparing different studies and drawing general conclusions is challenging, as these usually differ not only in the physico-chemical and structural properties of the biomaterials, but also in animal model, implantation site and duration of the study. Despite these limitations, the knowledge of material properties relevant for osteoinduction to occur has tremendously increased in the past decades. Here we review the properties of osteoinductive biomaterials, in the light of the model and the conditions under which they were tested. Furthermore, we give an insight into the biological processes governing osteoinduction by biomaterials and our view on the future perspectives in this research fi eld.

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Section: Future Perspectivesmentioning

confidence: 93%

Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms

Barradas

Yuan²,

Blitterswijk³

et al. 2011

eCM

446

365

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show abstract

“…In the context of TE, several researchers [ 52 , 53 , 54 , 55 ] have demonstrated that smart biomaterials have the ability to maintain and control cellular behavior for functional tissue regeneration. Yuan and coworkers [ 55 ] demonstrated that porous ceramic scaffolds alone induce substantial ectopic bone formation without the incorporation of molecules and/or cells.…”

Section: Importance Of Smart Biomaterials In Tementioning

confidence: 99%

Designing Smart Biomaterials for Tissue Engineering

Khan

Tanaka

2017

IJMS

221

129

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The engineering of human tissues to cure diseases is an interdisciplinary and a very attractive field of research both in academia and the biotechnology industrial sector. Three-dimensional (3D) biomaterial scaffolds can play a critical role in the development of new tissue morphogenesis via interacting with human cells. Although simple polymeric biomaterials can provide mechanical and physical properties required for tissue development, insufficient biomimetic property and lack of interactions with human progenitor cells remain problematic for the promotion of functional tissue formation. Therefore, the developments of advanced functional biomaterials that respond to stimulus could be the next choice to generate smart 3D biomimetic scaffolds, actively interacting with human stem cells and progenitors along with structural integrity to form functional tissue within a short period. To date, smart biomaterials are designed to interact with biological systems for a wide range of biomedical applications, from the delivery of bioactive molecules and cell adhesion mediators to cellular functioning for the engineering of functional tissues to treat diseases.

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“…Once implanted in the host bone, the degradation of CaPs, mostly mediated by the action of osteoclastic cells, result in the alteration of the ionic concentrations, mainly calcium and phosphate, in the surrounding extracellular fluids. It is generally accepted that both ions, either alone or simultaneously, foster the process of bone formation, by enhancing the activity of bone-forming cells, but also triggering the differentiation of mesenchymal stem cells to the osteogenic lineage[9,10,[29][30][31].…”

mentioning

confidence: 99%

In vitro response of mesenchymal stem cells to biomimetic hydroxyapatite substrates: A new strategy to assess the effect of ion exchange

et al. 2018

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Fluid mediated interactions play a significant role in the bioactivity of calcium phosphates. Ionic exchange is amplified in the case of biomimetic hydroxyapatite, which makes the in vitro characterisation of cell-material interactions especially challenging. The present work proposes a novel and simple strategy to explore the mechanisms of interaction of biomimetic and sintered calcium phosphates with mesenchymal stem cells. The effects of topography and ion exchange are analysed separately by modifying the volume ratio between cell culture medium and biomaterial. High ionic fluctuations interfered in the maturation of focal adhesions, hampering cell adhesion and leading to increased apoptosis and reduced proliferation rate.

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'Smart' biomaterials and osteoinductivity

Cited by 17 publications

References 2 publications

Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms

Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms

Designing Smart Biomaterials for Tissue Engineering

In vitro response of mesenchymal stem cells to biomimetic hydroxyapatite substrates: A new strategy to assess the effect of ion exchange

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