Smart carbon nanotubes for drug delivery system: A comprehensive study

Jha, Roopali; Singh, Amit; Sharma, Pramod Kumar; Fuloria, Neeraj Kumar

doi:10.1016/j.jddst.2020.101811

Cited by 100 publications

(57 citation statements)

References 248 publications

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“…Cell internalisation of nanotubes is through the outer cell membrane by endocytosis. Nanotubes can be used as a transporting system for bioactive molecules such as medications or genes after their functionalisation with ammonium or carboxylic groups to get them into a soluble form [ 38 ].…”

Section: Classification Of Nanostructuresmentioning

confidence: 99%

“…DNA can be joined to the tips of nanotubes or can be merged inside their chambers. Prato et al [ 38 ] provided an increasingly imperative explanation of the β-galactosidase marker quality through nanotubes appearing different compared to uncovered DNA. This shows the advantage of the non-immunogenicity method over viral vectors used for cancer diagnosis and treatment.…”

Section: Classification Of Nanostructuresmentioning

confidence: 99%

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Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

et al. 2021

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Designing of nanomaterials has now become a top-priority research goal with a view to developing specific applications in the biomedical fields. In fact, the recent trends in the literature show that there is a lack of in-depth reviews that specifically highlight the current knowledge based on the design and production of nanomaterials. Considerations of size, shape, surface charge and microstructures are important factors in this regard as they affect the performance of nanoparticles (NPs). These parameters are also found to be dependent on their synthesis methods. The characterisation techniques that have been used for the investigation of these nanomaterials are relatively different in their concepts, sample preparation methods and obtained results. Consequently, this review article aims to carry out an in-depth discussion on the recent trends on nanomaterials for biomedical engineering, with a particular emphasis on the choices of the nanomaterials, preparation methods/instruments and characterisations techniques used for designing of nanomaterials. Key applications of these nanomaterials, such as tissue regeneration, medication delivery and wound healing, are also discussed briefly. Covering this knowledge gap will result in a better understanding of the role of nanomaterial design and subsequent larger-scale applications in terms of both its potential and difficulties.

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Section: Classification Of Nanostructuresmentioning

confidence: 99%

Section: Classification Of Nanostructuresmentioning

confidence: 99%

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

et al. 2021

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“…12 Nowadays, the CNTs are utilized in drug delivery carriers, biomedical purposes, genetic engineering, artificial implants, imaging, cancer treatment, antioxidant activity, bio-sensing, etc. 13,14 In fact, CNTs are made in five ways, which are described as arc discharge, laser ablation, chemical vapor deposition, flame synthesis, and silane solution methods. Also, CNTs are purified in three ways as air oxidation, sonication, and acid refluxing.…”

Section: Introductionmentioning

confidence: 99%

“…Also, CNTs are purified in three ways as air oxidation, sonication, and acid refluxing. 13 On the other hand, the CNTs are a fascinating substance that can be employed to bind proteins, peptides, nucleic acids, and various drugs. 15 Furthermore, CNTs have a high potential for drug delivery due to their tubular and fiber-like structure.…”

Section: Introductionmentioning

confidence: 99%

<p>The Applications of Carbon Nanotubes in the Diagnosis and Treatment of Lung Cancer: A Critical Review</p>

Sheikhpour¹,

Naghinejad²,

Kasaeian³

et al. 2020

IJN

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The importance of timely diagnosis and the complete treatment of lung cancer for many people with this deadly disease daily increases due to its high mortality. Diagnosis and treatment with helping the nanoparticles are useful, although they have reasonable harms. This article points out that the side effects of using carbon nanotube (CNT) in this disease treatment process such as inflammation, fibrosis, and carcinogenesis are very problematic. Toxicity can reduce to some extent using the techniques such as functionalizing to proper dimensions as a longer length, more width, and greater curvature. The targeted CNT sensors can be connected to various modified vapors. In this regard, with helping this method, screening makes non-invasive diagnosis possible. Researchers have also found that nanoparticles such as CNTs could be used as carriers to direct drug delivery, especially with chemotherapy drugs. Most of these carriers were multi-wall carbon nanotubes (MWCNT) used for cancerous cell targeting. The results of laboratory and animal researches in the field of diagnosis and treatment became very desirable and hopeful. The collection of researches summarized has highlighted the requirement for a detailed assessment which includes CNT dose, duration, method of induction, etc., to achieve the most controlled conditions for animal and human studies. In the discussion section, 4 contradictory issues are discussed which are invited researchers to do more research to get clearer results.

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“…Of the highest interest in the field of nanotechnology are carbon-based nanomaterials especially carbon nanotubes (CNTs). CNTs have demonstrated unique physical, chemical, electrical, and mechanical properties [2][3][4][5][6][7][8][9] which made them a promising potential candidate for many novel systems and applications, such as nanoelectromechanical systems (NEMS), reinforced nanocomposites, biomedical treatment and appliance, and biological sensors [10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Fracture analysis and tensile properties of perfect and defective carbon nanotubes functionalized with carbene using molecular dynamics simulations

Ajori

Boroushak

Ansari

2020

J Braz. Soc. Mech. Sci. Eng.

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In this study, the tensile properties and fracture analysis of functionalized carbon nanotubes (CNTs) with carbene are investigated employing the molecular dynamics simulations. Tensile parameters, i.e., Young's modulus, ultimate stress, failure strain, and fracture progress, are determined, and the effects of different attachment types, distribution patterns, the weight percentage of functional groups as well as the presence of defect with various defect weights on the aforementioned values are explored. According to the results, the tensile parameters are highly sensitive to the attachment type of carbene. In general, functionalization reduces the value of tensile parameters, especially when the attachment of carbene to base CNT is perpendicular to the loading direction. Compared to the ultimate stress and the failure strain, Young's modulus is shown to be less affected by functionalization. It is demonstrated that the presence of defect, regardless of functionalization type and distribution pattern, reduces the tensile parameters. This reduction is more pronounced in the case of ultimate stress. Moreover, it is found that the toughness of CNTs reduces by functionalization and the presence of defects. Finally, it is demonstrated that functionalization with carbene and the presence of defects does not have a noticeable effect on the fracture progress of CNTs.

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Smart carbon nanotubes for drug delivery system: A comprehensive study

Cited by 100 publications

References 248 publications

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

<p>The Applications of Carbon Nanotubes in the Diagnosis and Treatment of Lung Cancer: A Critical Review</p>

Fracture analysis and tensile properties of perfect and defective carbon nanotubes functionalized with carbene using molecular dynamics simulations

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