Smart chemistry in polymeric nanomedicine

Tong, Rong; Tang, Li; Ma, Liang; Tu, Chunlai; Baumgartner, Ryan; Cheng, Jianjun

doi:10.1039/c4cs00133h

Cited by 180 publications

(125 citation statements)

References 507 publications

(507 reference statements)

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“…The disassembly behavior of redox-sensitive HA-ss-Chol 7 NPs was evaluated under different reductive conditions mimicking different in vivo environments. Briefly, in response to various concentrations of DTT, the PS changes of NPs (1 mg/mL) suspended in PBS buffer (pH 7.4, 0.1 M) were monitored in time by DLS.…”

Section: Dtt-triggered Disassembly Of Redox-sensitive Npsmentioning

confidence: 99%

“…The NP suspensions in different media were gently shaken at 37°C. As a control, the PS of HA-ss-Chol 7 NPs was recorded in PBS in the absence of the reducing agent under the same conditions. The contrast study was carried out by monitoring the PS of reduction-nonresponsive HA-Chol 7 NPs in response to 20 mM DTT.…”

Section: Dtt-triggered Disassembly Of Redox-sensitive Npsmentioning

confidence: 99%

“…NIR dye 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide (DiR) was encapsulated in GE11-HA-ss-Chol 7 NPs and HA-ss-Chol 7 NPs following drug loading protocol using ethanol as the solvent (DLC =1.5%). Female BALB/c nude mice were used to prepare MDA-MB-231 tumor-bearing xenograft mouse model.…”

Section: In Vivo and Ex Vivo Imaging Investigationsmentioning

confidence: 99%

“…Moreover, at a higher DTT concentration (20 mM), corresponding to the intracellular reduction levels in tumor cells, 40.08% of DOX was released in the first 4 hours and 79.67% was released after 48 hours. In contrast, HA-Chol 7 NPs slowly released the drug in the medium containing 20 mM DTT (35.05% over 48 hours), which had no significant difference with the release of DOX from HA-ss-Chol 7 NPs in 0 M DTT (31.37% over 48 hours) or 10 μM DTT (34.97% over 48 hours).…”

mentioning

confidence: 90%

“…The NPs were negatively charged with a zeta potential inferior to −20 mV. In addition, HA-Chol 7 NPs presented a slightly increased PS compared to HA-ss-Chol 7 NPs. Modification of the NPs with GE11 peptide resulted in an enlargement of PS and a minor variation of zeta potential.…”

mentioning

confidence: 95%

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GE11 peptide modified and reduction-responsive hyaluronic acid-based nanoparticles induced higher efficacy of doxorubicin for breast carcinoma therapy

Hu¹,

Mezghrani²,

Zhang³

et al. 2016

IJN

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Novel breast carcinoma dual-targeted redox-responsive nanoparticles (NPs) based on cholesteryl-hyaluronic acid conjugates were designed for intracellular delivery of the antitumor drug doxorubicin (DOX). A series of reduction-responsive hyaluronic acid derivatives grafted with hydrophobic cholesteryl moiety (HA-ss-Chol) and GE11 peptide conjugated HA-ss-Chol (GE11–HA-ss-Chol) were synthesized. The obtained conjugates showed attractive self-assembly characteristics and high drug loading capacity. GE11–HA-ss-Chol NPs were highly stable under conditions mimicking normal physiological conditions, while showing a fast degradation of the vehicle’s structure and accelerating the drug release dramatically in the presence of intracellular reductive environment. Furthermore, the cellular uptake assay confirmed GE11–HA-ss-Chol NPs were taken up by MDA-MB-231 cells through CD44- and epidermal growth factor receptor-mediated endocytosis. The internalization pathways of GE11–HA-ss-Chol NPs might involve clathrin-mediated endocytosis and macropinocytosis. The intracellular distribution of DOX in GE11–HA-ss-Chol NPs showed a faster release and more efficient nuclear delivery than the insensitive control. Enhanced in vitro cytotoxicity of GE11–HA-ss-Chol DOX-NPs further confirmed the superiority of their dual-targeting and redox-responsive capacity. Moreover, in vivo imaging investigation in MDA-MB-231 tumor-bearing mice confirmed that GE11–HA-ss-Chol NPs labeled with 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide, a near-infrared fluorescence dye, possessed a preferable tumor accumulation ability as compared to the single-targeting counterpart (HA-ss-Chol NPs). The antitumor efficacy showed an improved therapy efficacy and lower systemic side effect. These results suggest GE11–HA-ss-Chol NPs provide a good potential platform for antitumor drugs.

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Section: Dtt-triggered Disassembly Of Redox-sensitive Npsmentioning

confidence: 99%

Section: Dtt-triggered Disassembly Of Redox-sensitive Npsmentioning

confidence: 99%

Section: In Vivo and Ex Vivo Imaging Investigationsmentioning

confidence: 99%

mentioning

confidence: 90%

mentioning

confidence: 95%

See 3 more Smart Citations

GE11 peptide modified and reduction-responsive hyaluronic acid-based nanoparticles induced higher efficacy of doxorubicin for breast carcinoma therapy

Hu¹,

Mezghrani²,

Zhang³

et al. 2016

IJN

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Click Chemistry: Mechanistic and Synthetic Perspectives

Ramapanicker

Chauhan

2016

Click Reactions in Organic Synthesis

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Radiolabelled Polymeric Materials for Imaging and Treatment of Cancer: Quo Vadis?

Pant

Sedláček

Nadar

et al. 2017

Adv Healthcare Materials

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Owing to their tunable blood circulation time and suitable plasma stability, polymer-based nanomaterials hold a great potential for designing and utilising multifunctional nanocarriers for efficient imaging and effective treatment of cancer. When tagged with appropriate radionuclides, they may allow for specific detection (diagnosis) as well as the destruction of tumours (therapy) or even customization of materials, aiming to both diagnosis and therapy (theranostic approach). This review provides an overview of recent developments of radiolabelled polymeric nanomaterials (natural and synthetic polymers) for molecular imaging of cancer, specifically, applying nuclear techniques such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT). Different approaches to radiolabel polymers are evaluated from the methodical radiochemical point of view. This includes new bifunctional chelating agents (BFCAs) for radiometals as well as novel labelling methods. Special emphasis is given to eligible strategies employed to evade the mononuclear phagocytic system (MPS) in view of efficient targeting. The discussion encompasses promising strategies currently employed as well as emerging possibilities in radionuclide-based cancer therapy. Key issues involved in the clinical translation of radiolabelled polymers and future scopes of this intriguing research field are also discussed.

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Smart chemistry in polymeric nanomedicine

Cited by 180 publications

References 507 publications

GE11 peptide modified and reduction-responsive hyaluronic acid-based nanoparticles induced higher efficacy of doxorubicin for breast carcinoma therapy

GE11 peptide modified and reduction-responsive hyaluronic acid-based nanoparticles induced higher efficacy of doxorubicin for breast carcinoma therapy

Click Chemistry: Mechanistic and Synthetic Perspectives

Radiolabelled Polymeric Materials for Imaging and Treatment of Cancer: Quo Vadis?

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