Smart H₂O₂-Responsive Drug Delivery System Made by Halloysite Nanotubes and Carbohydrate Polymers

Abstract

A novel chemical hydrogel was facilely achieved by coupling 1,4-phenylenebisdiboronic acid modified halloysite nanotubes (HNTs-BO) with compressible starch. The modified halloysite nanotubes (HNTs) and prepared hydrogel were characterized by solid-state nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and transmission electron microscope (TEM). The linkage of B-C in the hydrogel can be degraded into B-OH and C-OH units in the presence of HO and result in the degradation of the chemical hydrogel. Pentoxifylline was loaded into the lumen of the HNTs-BO, and then gave the pentoxifylline-loaded hydrogel. The drug release profile shows that it was no more than 7% dissolved when using phosphate buffer solution (PBS) as the release medium. Notably, a complete release (near 90%) can be achieved with the addition of HO ([HO] = 1 × 10 M), suggesting a high HO responsiveness of the as-formed hydrogel. The drug release results also show that the "initial burst release" can be effectively suppressed by loading pentoxifylline inside the lumen of the HNTs rather than embedding the drug in the hydrogel network. The drug-loaded hydrogel with HO-responsive release behavior may open up a broader application in the field of biomedicine.

Layered composite based on halloysite and natural polymers: a carrier for the pH controlled release of drugs

“…4,5 Mostly, organic raw materials derive from agricultural or marine sources that can be functionalized in order to tune their main features such as the hydrophilic character, the thermal stability and the solubilization capability towards other compounds. [6][7][8] The biopolymers' charge is considered as a crucial point for their classification since they can be cationic (e.g. chitosan), anionic (e.g.…”

Core/Shell Gel Beads with Embedded Halloysite Nanotubes for Controlled Drug Release

“…This different charge, due to the chemical composition, allows for selective functionalization, exploiting both the covalent and electrostatic interactions of each surface with other oppositely charged species: Drug molecules, polysaccharides, proteins, lipids, surfactants and so on [27][28][29]. All these features, and also considering that they are low cost, eco-and biocompatible materials [30], make HNTs suitable for designing hybrid materials for waste water remediation [31][32][33][34][35], cultural heritage treatment [36,37], biotechnological applications [38][39][40][41][42][43][44], and packaging [45][46][47][48][49][50].…”

Tough, High stretched, Self‐healing C‐dots/Hydrophobically Associated Composited Hydrogels and Their Use for a Fluorescence Sensing Platform

“…Based on these results, it is necessary to detect H 2 O 2 . H 2 O 2 is one of the most important source of reactive oxygen species (ROS) involving a variety of pathological effects in organisms . Decomposition of H 2 O 2 formed ROS and the ROS induces fluorescence quenching of the C‐dots significantly through an etching process .…”