Smart Injectable Self-Setting Monetite Based Bioceramics for Orthopedic Applications

Abstract

The present study is the first of its kind dealing with the development of a specific bioceramic which qualifies as a potential material in hard-tissue replacements. Specifically, we report the synthesis and evaluation of smart injectable calcium phosphate bone cement (CPC) which we believe will be suitable for various kinds of orthopedic and spinal-fusion applications. The smart nature of this next generation orthopedic implant is attained by incorporating piezoelectric barium titanate (BT) particles into monetite-based (dicalcium phosphate anhydrous, DCPA) CPC composition. The main goal is to take advantage of the piezoelectric properties of BT, as electromechanical effect plays a vital role in fracture healing at the defect site and bone integration with the implant. Furthermore, radiopacity of BT would help in easy detection of the CPC presence at the fracture site during surgery. Results reveal that BT addition favors important properties of bone cement such as good compressive strength, injectability, bioactivity, biocompatibility, and even washout resistance. Most importantly, the self-setting nature of the bone cements are not compromised with BT incorporation. The in vitro results confirm that the developed bone-cement abides by the standard orthopedic requirements making it apt for real-time prosthetic materials.

Silver (Ag) doped magnesium phosphate microplatelets as next‐generation antibacterial orthopedic biomaterials

“…In MTT, OD readings present a direct correlation with the cell viability (Sikder, Koju, Lin, & Bhaduri, n.d.; Koju, Sikder, Gaihre, & Bhaduri, ). In the present case, the viability of MC3T3 pre‐osteoblast cells as cultured on undoped and Ag‐doped NB powders are reported.…”

“…However, just like previous efforts (Ren et al, ), relatively low ALP expressions are also recorded in undoped and Ag‐doped NB. This can be attributed to the fast release of Mg and consumption of Ca in the biomineralization process which in turn lowers the β‐glycerophosphate (BGP) induced ALP activity (Koju et al, ; Ren et al, ). It is worth mentioning that the doped single‐phase materials like NB‐1Ag, NB‐1.5Ag, and NB‐2Ag materials possess effective antibacterial properties and similar bone regenerative potential to well‐known and well‐explored CaPs.…”

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

“…These biodegradable materials, particularly calcium phosphates and mesoporous BGs, are generally no longer used as monolithic or bulk phases but rather as porous scaffolds as a way to further stimulate interactions with bone tissue and its self-healing properties ( Huang, 2017 ; Vallet-Regí and Salinas, 2019 ). Fundamental aspects in this group of ceramics are firstly their “smart” capacity to adapt and modify their properties to the changing implant site environment, and secondly, a diverse handling method, mostly at room temperature, that allow the inclusion and preservation of bioactive molecules (drugs/antibiotics, growth factors, magnetic particles for thermal cancer therapy) ( Vallet-Regi et al, 2012 ; Comesaña et al, 2015 ; Koju et al, 2018 ; Vallet-Regí and Salinas, 2019 ). With the purpose to obtain enhanced therapeutic effectiveness, these materials were therefore tested in many studies as drug carriers or as gene delivery systems ( Ruiz-Hernández et al, 2008 ; Liu et al, 2009 ; Vallet-Regí and Ruiz-Hernández, 2011 ; Wu and Chang, 2014 ; Gao et al, 2015 ; Santos et al, 2017 ; Köse et al, 2018 ; Afewerki et al, 2020 ).…”

Mechanochemical Synthesis of BaTiO3 Powders and Evaluation of Their Acrylic Dispersions

“…The ferroelectric properties of barium titanate have been also taken into account during the designing of the materials fabricated for the energy storage application [12][13][14] or the energy conversion [15]. On the other hand, barium titanate has also found wide application in medicine, e.g., in tissue engineering [16][17][18][19][20][21]. Different methodologies for the fabrication of barium titanate/hydroxyapatite scaffold, e.g., multistage spark plasma sintering [22], hydrothermal process [23], or pulsed laser deposition [24], have been investigated.…”