“…KEYWORDS: signal-triggered release, biomolecule release, orthogonal reactions, multifunctional release system, micro/nanosystem "Smart" functional materials can change their properties following external signals. 1 Numerous examples of "smart" materials and systems, particularly for signal-triggered (bio)molecule release 2 (e.g., drug release), 3 signal-stimulated shape/ size changes, 4 signal-regulated porosity, 5 variable optical, 6 electric, 7 magnetic, 8 features, self-healing, 9 switchable wettability, 10 and many other applications have been extensively studied in the last decades and reported in numerous papers and books. The signals applied to change the system properties include (bio)molecule inputs 11 (e.g., pH change), 12 temperature changes, 13 light illumination, 14 magnetic field 15 and electrical potentials 16 being applied, and so on.…”