Brain-computer interfaces (BCI) provide a mobility solution for patients with various disabilities. However, BCI systems require further research to enhance their performance, while incorporating the physical and behavioral states of patients into the system. As the principal users of a BCI system, patients with disabilities are emotionally sensitive, so a BCI device that adaptively tunes toward patient’s psychological effects, could provide the foundation for refining the BCI applications. This paper focuses on the collection and realization of the electroencephalogram (EEG) signals data of humans, obtained as a response to different psychological effects of sound stimuli. Filtration and preprocessing of the dataset are achieved using the frequency-based distribution of EEG signals. Different machine learning tools and techniques are evaluated and applied to abstracted powerbands of psychological signals. The experimental results show that the proposed system predicts mental states with an average accuracy of 74.26\%. Moreover, an automated BCI system is developed to control an electric-powered wheelchair (EPW) while responding to the user’s mental state with a contingency mechanism. The results show that such a system could be designed to make BCI systems more reliable, safe, adaptable, and emotion-responding for sensitive paralytic patients. The system also shows a satisfactory True Positive Rate (TPR) and False Positive Rate (FPR) with an average time of 8.4 seconds to generate the interpretable brain signal from the user.