Smart nanocontainers and nanoreactors

Kim, Kyoung Taek; Meeuwissen, Silvie A.; Nolte, Roeland J. M.; Hest, Jan C. M. van

doi:10.1039/b9nr00409b

Cited by 199 publications

(188 citation statements)

References 166 publications

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“…They provide an advantage of the ability to encapsulate hydrophilic molecules in their interior protected from the outside environment; compared to micelles which preferentially encapsulate hydrophobic molecules. Reviews on this subject that include thermoresponsive polymersomes have been published previously by Meng et al [117], Du and O'Reilly [118] and Kim et al [119].…”

Section: Polymersomesmentioning

confidence: 99%

Thermoresponsive Polymers for Biomedical Applications

2011

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Thermoresponsive polymers are a class of "smart" materials that have the ability to respond to a change in temperature; a property that makes them useful materials in a wide range of applications and consequently attracts much scientific interest. This review focuses mainly on the studies published over the last 10 years on the synthesis and use of thermoresponsive polymers for biomedical applications including drug delivery, tissue engineering and gene delivery. A summary of the main applications is given following the different studies on thermoresponsive polymers which are categorized based on their 3-dimensional structure; hydrogels, interpenetrating networks, micelles, crosslinked micelles, polymersomes, films and particles.

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Section: Polymersomesmentioning

confidence: 99%

Thermoresponsive Polymers for Biomedical Applications

2011

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“…In biotechnology of synthetic systems, a current trend is to exploit the possibility of assembling functional biomolecules within prototypical devices in which the levels of crowding and compartmentalization are representative of those of living systems [3][4][5][6][7][8][9][10][11][12][13][14][15] . Little is known about the effect of confinement on the properties and functions of these molecules within such crowded systems 1,2 ; thus, novel in vitro approaches can provide key information in aiding future biotechnology developments.…”

mentioning

confidence: 99%

Two-dimensional enzyme diffusion in laterally confined DNA monolayers

et al. 2011

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Addressing the effects of confinement and crowding on biomolecular function may provide insight into molecular mechanisms within living organisms, and may promote the development of novel biotechnology tools. Here, using molecular manipulation methods, we investigate restriction enzyme reactions with double-stranded (ds)DnA oligomers confined in relatively large (and flat) brushy matrices of monolayer patches of controlled, variable density. We show that enzymes from the contacting solution cannot access the dsDnAs from the topmatrix interface, and instead enter at the matrix sides to diffuse two-dimensionally in the gap between top-and bottom-matrix interfaces. This is achieved by limiting lateral access with a barrier made of high-density molecules that arrest enzyme diffusion. We put forward, as a possible explanation, a simple and general model that relates these data to the steric hindrance in the matrix, and we briefly discuss the implications and applications of this strikingly new phenomenon.

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“…The literature describes an approach based on the combination of several components of a diverse structure due to various noncovalent interactions, e.g. hydrogen bonds, [2] metal-ligand coordination, [3] electrostatic, [4][5][6] pi-stacking, [7] and "hostguest" interactions [8] with the formation of superamphiphiles, which allowed creating a large number of systems possessing the properties of nanocontainers [9] and molecular devices. [10] Due to the dynamic nature of the non-covalent interactions of the superamphiphiles, it becomes possible to easily control their self-assembly and the properties of the emerging structures under the influence of various external factors.…”

Section: Introductionmentioning

confidence: 99%