Smart Synthesis of Hollow Microporous Organic Capsules with a Polyaniline Modified Shell

Li, Qingyin; Cheng, Ying; Razzaque, Shumaila; Cao, Zuolin; Ren, Shijie; Tan, Bien

doi:10.1002/marc.202100836

Cited by 7 publications

(5 citation statements)

References 52 publications

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Section: Tunable Structuresmentioning

confidence: 99%

“…Tan group reported the preparation of hollow microporous organic capsules (HMOCs) with controlled morphologies using a templating approach by utilizing silica nanoparticles as the core templates (Figure 2B). 30,94 This approach resulted in HMOCs with hollow cavities, controlled shell thickness, and zero-level drug release kinetics, which makes them suitable for drug delivery. Another similar template method of using silica nanorods was employed to synthesize hollow microporous organic nanorods (HMORs) with tunable aspect ratios and HCPs shells.…”

Section: Designed Morphologiesmentioning

confidence: 99%

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Rational design of hyper‐crosslinked polymers for biomedical applications

Qian

Kim

Tang

et al. 2023

Journal of Polymer Science

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Hyper‐crosslinked polymers (HCPs) are a family of polymers that possess several desirable characteristics, including high specific surface area, excellent stability, tunable porous structures, and low‐cost reagents. As a result, HCPs have gained significant attention in the areas of gas storage, adsorption, catalysis, separation, and carbon precursors, exhibiting advanced performances in catalytic and energy‐related applications. Recently, researchers have explored the potential of HCPs in biomedical engineering. In this review, we discuss classical synthesis strategies and morphological assembly methods used to create HCPs with unique biological properties. We also highlight the latest advances in emerging biomedical areas of HCPs, such as drug delivery, antimicrobial, bioimaging, and biosensing. By providing various examples, we further discuss the correlations between the structures, morphologies, and enhanced biomedical properties of the HCPs. Finally, we summarize the key applications of HCPs and provide an outlook on the research direction to encourage further development of biomedically available HCPs. Overall, HCPs offer promising potential as a new class of materials for use in biomedical applications, and continued research in this field will lead to exciting discoveries and breakthroughs.

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Section: Tunable Structuresmentioning

confidence: 99%

Section: Designed Morphologiesmentioning

confidence: 99%

Rational design of hyper‐crosslinked polymers for biomedical applications

Qian

Kim

Tang

et al. 2023

Journal of Polymer Science

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“…The exceptional catalytic performance is attributed to the catalyst’s high surface area and abundant hierarchical porosity. In 2022, they further advanced their work by synthesizing a new type of hyper-crosslinked polymer-based hollow organic microcapsules (PANI@S-HMOCs) [ 81 ]. This was achieved by in situ polymerizing aniline within the porous structure of sulfonated hollow mesoporous organic capsules (S-HMOCs), resulting in a modified shell composed of polyaniline (PANI).…”

Section: Structure-oriented Design Of Hyper-crosslinked Polymer Nanom...mentioning

confidence: 99%

Hyper-Crosslinked Porous Organic Nanomaterials: Structure-Oriented Design and Catalytic Applications

Luo,

Mei,

et al. 2023

Nanomaterials

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Hyper-crosslinked porous organic nanomaterials, especially the hyper-crosslinked polymers (HCPs), are a unique class of materials that combine the benefits of high surface area, porous structure, and good chemical and thermal stability all rolled into one. A wide range of synthetic methods offer an enormous variety of HCPs with different pore structures and morphologies, which has allowed HCPs to be developed for gas adsorption and separations, chemical adsorption and encapsulation, and heterogeneous catalysis. Here, we present a systematic review of recent approaches to pore size modulation and morphological tailoring of HCPs and their applications to catalysis. We mainly compare the effects of pore size modulation and morphological tailoring on catalytic applications, aiming to pave the way for researchers to develop HCPs with an optimal performance for modern applications.

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“…Cells have been encapsulated in microporous, nanofibrous, and hydrogel scaffolds to overcome the limitations of 2D cell cultures and to grow cells more effectively in the laboratory [ 13 ]. The microporous system has the advantage of conveniently suturing cells, which effectively serves as a 2D support with curvature because the particle size of the material used is larger than that of the cells [ 14 ], but it is associated with some disadvantages, especially uncontrollable porous structures [ 15 ]. Nanofiber scaffolds can better create extracellular structures formed by fibrous proteins [ 16 ].…”

Section: Three-dimensional Cell Culture Technologymentioning

confidence: 99%

Current Research Trends in the Application of In Vitro Three-Dimensional Models of Liver Cells

2022

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The liver produces and stores various nutrients that are necessary for the body and serves as a chemical plant, metabolizing carbohydrates, fats, hormones, vitamins, and minerals. It is also a vital organ for detoxifying drugs and exogenous harmful substances. Culturing liver cells in vitro under three-dimensional (3D) conditions is considered a primary mechanism for liver tissue engineering. The 3D cell culture system is designed to allow cells to interact in an artificially created environment and has the advantage of mimicking the physiological characteristics of cells in vivo. This system facilitates contact between the cells and the extracellular matrix. Several technically different approaches have been proposed, including bioreactors, chips, and plate-based systems in fluid or static media composed of chemically diverse materials. Compared to conventional two-dimensional monolayer culture in vitro models, the ability to predict the function of the tissues, including the drug metabolism and chemical toxicity, has been enhanced by developing three-dimensional liver culture models. This review discussed the methodology of 3D cell cultures and summarized the advantages of an in vitro liver platform using 3D culture technology.

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Smart Synthesis of Hollow Microporous Organic Capsules with a Polyaniline Modified Shell

Abstract: In this work, novel hypercrosslinked polymer-based hollow microporous organic capsules with a polyaniline (PANI)-modified shell (PANI@S-HMOCs) are prepared by in-situ polymerization of aniline in the porous structure of the sulfonated hollow microporous organic capsules (S-HMOCs).

Cited by 7 publications

References 52 publications

Rational design of hyper‐crosslinked polymers for biomedical applications

Rational design of hyper‐crosslinked polymers for biomedical applications

Hyper-Crosslinked Porous Organic Nanomaterials: Structure-Oriented Design and Catalytic Applications

Current Research Trends in the Application of In Vitro Three-Dimensional Models of Liver Cells

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