2019
DOI: 10.3390/pathogens8040182
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“Smart” Triiodide Compounds: Does Halogen Bonding Influence Antimicrobial Activities?

Abstract: Antimicrobial agents containing symmetrical triiodides complexes with halogen bonding may release free iodine molecules in a controlled manner. This happens due to interactions with the plasma membrane of microorganisms which lead to changes in the structure of the triiodide anion. To verify this hypothesis, the triiodide complex [Na(12-crown-4)2]I3 was prepared by an optimized one-pot synthesis and tested against 18 clinical isolates, 10 reference strains of pathogens and five antibiotics. The antimicrobial a… Show more

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Cited by 31 publications
(116 citation statements)
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References 53 publications
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“…Polyiodides contain [I 2k+n ] n− units with stabilizing donor-acceptor interactions of I 2 and iodide ions [ 21 , 22 ]. Iodine is an important microbicide and has many applications in the medical field, as commercial disinfectants, and against biohazards [ 20 , 23 , 24 , 25 , 26 ].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Polyiodides contain [I 2k+n ] n− units with stabilizing donor-acceptor interactions of I 2 and iodide ions [ 21 , 22 ]. Iodine is an important microbicide and has many applications in the medical field, as commercial disinfectants, and against biohazards [ 20 , 23 , 24 , 25 , 26 ].…”
Section: Introductionmentioning
confidence: 99%
“…Complexed compounds with iodine are interesting materials and can be designed in the form of different polyiodides [ 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. Halogen bonding within the polyiodide units are “smart” reservoirs of molecular iodine [ 22 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. These reservoirs can be utilized against pathogenic microorganisms through the controlled release of iodine from the complexed halogen-bonded polyiodides [ 22 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ].…”
Section: Introductionmentioning
confidence: 99%
“…Iodine is an important antimicrobial agents and has many applications in the medical field [71][72][73][74]. Complexed compounds with iodine offer potential agents with controlled release of iodine from polyiodides against pathogenic microorganisms [75][76][77][78][79][80]. The quest for antimicrobial agents should culminate in effective coating agents for masks, gloves, personal protective equipment, surfaces, wound-care products, surgical materials and medical equipment to prevent microbial adsorption.…”
Section: Role Of Basic Sciences Against Covid-19 and Antibiotic Resismentioning
confidence: 99%
“…It should not remain unmentioned that polyiodide species may be used as ambipolar zinc electrolytes [12] and further promoted some developments in the field of lithium-iodine redox batteries [13]. There are new considerations that suggest they might have anti-microbial properties [14]. A well established field of research is the synthesis of new polyiodide-containing salts based on organic cations [15].…”
Section: Commentmentioning
confidence: 99%