Smarter cures to combat COVID-19 and future pathogens: a review

Han, Dezhuan; Han, Jie; Lichtfouse, Éric

doi:10.1007/s10311-021-01224-9

Cited by 27 publications

(30 citation statements)

References 116 publications

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“…In addition, ventilation and air filtration in hospitals and other public buildings have been recommended to clear out infectious aerosols. Lastly, improving immunity by eating nutritious food, doing daily physical activity, stress management and enough sleep are advised (Ibarra-Coronado et al 2015;Dai et al 2021). All these practices have found to be effective in controlling viral dissemination to some extent.…”

Section: Prevention and Treatmentmentioning

confidence: 99%

“…COVID-19 variants are formed under selective pressure in the convalescent plasma therapy, thus inducing the rapid development of antibiotic-resistant mutations (Kemp et al 2020;Dai et al 2021). Selective pressure is a natural phenomenon in which the drug-survived COVID-19 variants pass on the resistant gene to the subsequent generation, whereas the drug-susceptible variants perish and do not produce offspring.…”

Section: Variants Complicate Detection and Treatmentmentioning

confidence: 99%

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Nanozymes to fight the COVID-19 and future pandemics

et al. 2021

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In 2019, the pandemic induced by the rapid spread of the severe acute respiratory syndrome coronavirus-2 'SARS-CoV-2', also named coronavirus disease 'COVID-19', has rapidly caused serious health, economic, social, and political issues worldwide. This has been accentuated by asymptomatic carriers, fast viral mutations, incoherent lockdown policies, and limited methods of detection and treatment. Nucleic acid tests for COVID-19 are lengthy and complicated, and the rapid antibody tests produce false-negative diagnoses, particularly in the early stage of infection. Moreover, there are no specific and effective medicines available for treatment. Therefore, rapid diagnostics and therapeutics are urgently required. Here, we argue that nanozymesenzyme-mimicking nanoparticles-could be used for faster, more sensitive, and accurate detection and treatment of the COVID-19. Indeed, nanozymes have high surface areas allowing easier bioconjugation for detection, and nanozymes possess integrated drug-functionalization for treatment. Moreover, the size, composition, and surface chemistry of nanozymes can be rationally designed for improved theranostic applications. COVID-19 historyThe COVID-19 appeared in Wuhan, China, due to emergence of a novel strain of coronavirus (Sallard et al. 2021), which was provisionally named '2019-nCoV' by the World Health Organization (WHO). Later, the virus was renamed 'SARS-CoV-2' by the International Committee

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Section: Prevention and Treatmentmentioning

confidence: 99%

Section: Variants Complicate Detection and Treatmentmentioning

confidence: 99%

Nanozymes to fight the COVID-19 and future pandemics

et al. 2021

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“…Here we discuss some potential links between anthropogenic influences and the behaviors of wildlife, as a possible explanation for the increasingly frequent spillover of zoonotic pathogens to humans. In the past 20 years, zoonotic diseases, such as the severe acute respiratory syndrome (SARS), the Middle East respiratory syndrome (MERS) and recently, the novel coronavirus disease (COVID-19), have caused large outbreaks on a regional or global scale (Dai et al 2021 ; Khan et al 2021 ; Sharma et al 2020 , 2021 ). Many have speculated that bats, a pervasive species and a major reservoir of coronaviruses and other viral pathogens (Kupferschmidt 2017 ; Maxmen 2017 ; Sallard et al 2021 ; Segreto et al 2021 ), are natural hosts of those novel zoonotic pathogens, including the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which has caused the recent COVID-19 pandemic with about 160 million people already infected around the globe (WHO 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…There are at least 3200 coronaviruses that infect bats (Burki 2020 ). As the world is still grappled with the novel coronavirus and its emerging variants (Dai et al 2021 ), bats, the pervasive nocturnal species frequently spotted in urban and other human settlements (Fig. 1 ), are once again under the spotlight (Irving et al 2021 ; Watson 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Have artificial lighting and noise pollution caused zoonosis and the COVID-19 pandemic? A review

Shao

Han

2021

Environ Chem Lett

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Where did the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) come from? Did it spread to ‘patient zero’ through proactive human-animal contact? Why did humans faced an increasing number of zoonotic diseases in the past few decades? In this article, we propose a new theory by which human pollution such as artificial lighting and noise accentuate pathogen shedding from bats and other wild habitants in urban environments. This theory differs from the current hypothesis that wildlife trades and bushmeat consumption largely contribute to the spillover of zoonotic pathogens to humans. As natural reservoirs, bats harbor the greatest number of zoonotic viruses among all mammalian orders, while they also have a unique immune system to maintain functioning. Some bat species roost in proximity with human settlements, including urban communities and surrounding areas that are potentially most impacted by anthropogenic activities. We review the behavioral changes of wild habitants, including bats and other species, caused by environmental pollution such as artificial lighting and noise pollution, with focus on the spillover of zoonotic pathogens to humans. We found that there is a strong positive correlation between environmental stress and the behavior and health conditions of wild species, including bats. Specifically, artificial lighting attracts insectivorous bats to congregate around streetlights, resulting in changes in their diets and improved likelihood of close contact with humans and animals. Moreover, many bat species avoid lit areas by expending more energies on commuting and foraging. Noise pollution has similar effects on bat behavior. Bats exposed to chronic noise pollution have weakened immune functions, increased viral shedding, and declined immunity during pregnancy, lactation, and vulnerable periods due to noised-induced stress. Other wild species exposed to artificial lighting and noise pollution also show stress-induced behaviors and deteriorated health. Overall, evidence supports our hypothesis that artificial lighting and noise pollution have been overlooked as long-term contributors to the spillover of zoonotic pathogens to humans in urban environments.

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“…Since, unfortunately, novel pandemics and climate crises are very likely to come, we urgently need to develop a long-term vision for more effective solutions such as the 'three Cs' strategy, which suggests avoiding crowded places, close-contact settings, and confined spaces (Ufnalska 2020a). Solutions include keeping away from indoor air pollution, promoting of a healthy lifestyle, fighting with addictions, fever phobia and bureaucracy, and other smarter cures (Ufnalska 2020a;Dai et al 2021). In this context, we highlight below eleven vital challenges concerning environmental pollution, COVID-19-related health issues and our well-being.…”

mentioning

confidence: 99%