Smartphone-based mobile biosensors for the point-of-care testing of human metabolites

Zhang, Meiying; Cui, Xin; Li, Nan

doi:10.1016/j.mtbio.2022.100254

Cited by 37 publications

(16 citation statements)

References 116 publications

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“…Otherwise, to limit non-specific biorecognition events at the surface, exposure to inert proteins such as serum albumin [ 75 ] and casein [ 76 ] is strongly recommended prior to any biomarker detection at room temperature. Moreover, corroboration with conventional invasive (liquid and tissue biopsy [ 77 ]) and non-invasive (e.g., enzyme-linked immunosorbent and immunology-based assays [ 78 ] and electrophoretic separation [ 79 ]) diagnostic methods with a smartphone-based mobile detection platform are urgently needed for rapid screening between false positive/negative data and to help physicians make an accurate diagnosis of patients before drug treatment and surgical investigations [ 80 , 81 , 82 , 83 , 84 ]. Thus, there is no doubt that low-cost portable cassette sets with pre-treated (e.g., improved Cys/GA chemistry coupled to milder reducing agents and blocking buffers [ 85 , 86 , 87 , 88 ]) stable supports based on paper [ 89 , 90 , 91 ], regular/ultrafine glass [ 92 , 93 , 94 ], or flexible fiber polymers [ 95 , 96 ] embedded with metallic nanoparticles will continue to attract great interest in the academic and medical [ 97 , 98 , 99 , 100 ] research communities.…”

Section: Discussionmentioning

confidence: 99%

Use of Cysteamine and Glutaraldehyde Chemicals for Robust Functionalization of Substrates with Protein Biomarkers—An Overview on the Construction of Biosensors with Different Transductions

Ionescu

2022

Biosensors

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Currently, several biosensors are reported to confirm the absence/presence of an abnormal level of specific human biomarkers in research laboratories. Unfortunately, public marketing and/or pharmacy accessibility are not yet possible for many bodily fluid biomarkers. The questions are numerous, starting from the preparation of the substrates, the wet/dry form of recognizing the (bio)ligands, the exposure time, and the choice of the running buffers. In this context, for the first time, the present overview summarizes the pre-functionalization of standard and nanostructured solid/flexible supports with cysteamine (Cys) and glutaraldehyde (GA) chemicals for robust protein immobilization and detection of biomarkers in body fluids (serum, saliva, and urine) using three transductions: piezoelectrical, electrochemical, and optical, respectively. Thus, the reader can easily access and compare step-by-step conjugate protocols published over the past 10 years. In conclusion, Cys/GA chemistry seems widely used for electrochemical sensing applications with different types of recorded signals, either current, potential, or impedance. On the other hand, piezoelectric detection via quartz crystal microbalance (QCM) and optical detection by surface plasmon resonance (LSPR)/surface-enhanced Raman spectroscopy (SERS) are ultrasensitive platforms and very good candidates for the miniaturization of medical devices in the near future.

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Section: Discussionmentioning

confidence: 99%

Use of Cysteamine and Glutaraldehyde Chemicals for Robust Functionalization of Substrates with Protein Biomarkers—An Overview on the Construction of Biosensors with Different Transductions

Ionescu

2022

Biosensors

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“…Consequently, smartphone-based colorimetric sensors are promising for rapid sensing and quantifying substances [ 46 , 47 ]. Color identification can be achieved by a smartphone camera and high-performance processer without the use of additional equipment ( Figure 2 ) [ 48 ]. Recently, target analytes, such as pathogens, the SARS-CoV-2 virus, Zika virus, metal ions, organic pollutants, and hormones, were detected by colorimetric sensors [ 24 ].…”

Section: Smartphone-based Sensing Methodsmentioning

confidence: 99%

“…Tetracycline, a widely used antibiotic, was detected by a smart, ratiometric fluorescent sensor created by Wang et al [ 54 ]. Chemiluminescence analysis is another optical sensing technique that uses light to determine the concentration of a chemical element or chemical compound in a solution without a light source and spectroscopic system [ 48 ]. Recently, a chemiluminescence smartphone sensor was developed by Kholafazad-Kordasht et al for simultaneous clinical diagnosis of salivary cortisol, valproic acid, and coronavirus [ 24 ].…”

Section: Smartphone-based Sensing Methodsmentioning

confidence: 99%

Smartphone-Based Multiplexed Biosensing Tools for Health Monitoring

et al. 2022

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Many emerging technologies have the potential to improve health care by providing more personalized approaches or early diagnostic methods. In this review, we cover smartphone-based multiplexed sensors as affordable and portable sensing platforms for point-of-care devices. Multiplexing has been gaining attention recently for clinical diagnosis considering certain diseases require analysis of complex biological networks instead of single-marker analysis. Smartphones offer tremendous possibilities for on-site detection analysis due to their portability, high accessibility, fast sample processing, and robust imaging capabilities. Straightforward digital analysis and convenient user interfaces support networked health care systems and individualized health monitoring. Detailed biomarker profiling provides fast and accurate analysis for disease diagnosis for limited sample volume collection. Here, multiplexed smartphone-based assays with optical and electrochemical components are covered. Possible wireless or wired communication actuators and portable and wearable sensing integration for various sensing applications are discussed. The crucial features and the weaknesses of these devices are critically evaluated.

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“…Recent studies focused on applications of smartphone-powered biomedical devices with biochemical, immunological, and genetic characterization 62 . Instant monitoring of Uric Acid (UA) 63 , immunological detection of HIV 64 , prostate-specific antigen (PSA) 65 , and protein bio-markers demonstrate using smartphones as tiny electrochemical analyzers at the point of care. This research presented an IoMT device (Medical dongle) powered by a smartphone and functions as a miniature electrochemical analyzer to measure uric acid and blood sugar using a disposable test strip.…”

Section: Smartphone Powered Iomt Devicesmentioning

confidence: 99%

Blockchain-Enabled Secure and Efficient Data Sharing Scheme for Trust Management in Healthcare Smartphone Network

Bhan

Pamula

Faruki³

et al. 2022

Preprint

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Internet of Medical Things (IoMT) is an extended genre of Internet of Things (IoT) where the Things collaborate to provide remote patient health monitoring, also known as the Internet of Health (IoH). Smartphones and IoMTs' are expected to maintain a secure and trusted confidential patient-records exchange while managing the patient remotely. Healthcare organizations deploy Healthcare Smartphone Networks (HSN) for confidential patient data collection and sharing among smartphone users and IoMT nodes. However, the attackers gain access to confidential patient data via compromised/malicious IoMT nodes from the HSN. Additionally, attackers can compromise the entire network via the compromised nodes. This article proposes a Hyperledger blockchain-based technique to identify the compromised IoMT nodes and safeguard sensitive patient records. Furthermore, the paper proposes a Clustered Hierarchical Trust Management System (CHTMS) to block malicious nodes. In addition, the proposal employs Elliptic Curve Cryptography (ECC) to protect sensitive health records. Similarly, the proposed approach is resilient against denial of service, eclipse attacks, and terminal device failure. Finally, the evaluation results show that integrating blockchains into the HSN system improved the detection performance compared to the existing state-of-the-art. Therefore, the simulation results indicate better security and reliability when compared to conventional databases.

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Smartphone-based mobile biosensors for the point-of-care testing of human metabolites

Cited by 37 publications

References 116 publications

Use of Cysteamine and Glutaraldehyde Chemicals for Robust Functionalization of Substrates with Protein Biomarkers—An Overview on the Construction of Biosensors with Different Transductions

Use of Cysteamine and Glutaraldehyde Chemicals for Robust Functionalization of Substrates with Protein Biomarkers—An Overview on the Construction of Biosensors with Different Transductions

Smartphone-Based Multiplexed Biosensing Tools for Health Monitoring

Blockchain-Enabled Secure and Efficient Data Sharing Scheme for Trust Management in Healthcare Smartphone Network

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