Smoke Inhalation Injury Causes Myocardial Depression in Sheep

Sugi, Kazuro; Newald, J; Traber, L. D.; Maguire, J.; Herndon, D. N.; Schlag, G.; Traber, D. L.

doi:10.1097/00000542-198809010-00111

Cited by 9 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They found that maximal contractile effects were reduced after either burn injury or inhalation injury [72,73]. Horton et al demonstrated decreased left ventricular contractility in isolated, coronary perfused, guinea pig hearts harvested 24 hours after burn injury [74].…”

Section: Myocardial Dysfunctionmentioning

confidence: 99%

Pathophysiology of burns

Keck

Herndon

Kamolz

et al. 2009

Wien Med Wochenschr

112

View full text Add to dashboard Cite

Burn injury represents a significant problem worldwide. Advances in therapy strategies, based on better understanding of the pathophysiologic responses after burn injury have improved the clinical outcome of patients with burn injuries over the past years. This article describes the present understanding of the pathophysiology of a burn injury including both the local and systemic responses, focusing on the many facets of organ and systemic effects directly resulting from hypovolemia and circulating mediators following burn trauma.

show abstract

Section: Myocardial Dysfunctionmentioning

confidence: 99%

Pathophysiology of burns

Keck

Herndon

Kamolz

et al. 2009

Wien Med Wochenschr

112

View full text Add to dashboard Cite

show abstract

“…On the other hand, our laboratory has demonstrated that smoke inhalation causes a delayed onset of myocardial depression. Sugi et al (30) reported that left ventricular contractility was significantly decreased 24 h after smoke inhalation. However, the time course and mechanism responsible for the cardiopulmonary hemodynamic alterations are still unclear when cutaneous burn injury is associated with smoke inhalation injury.…”

mentioning

confidence: 99%

Pathophysiological analysis of combined burn and smoke inhalation injuries in sheep

Soejima

Schmalstieg

Sakurai

et al. 2001

American Journal of Physiology-Lung Cellular and Molecular Phys

108

View full text Add to dashboard Cite

We investigated the pathophysiological alterations seen with combined burn and smoke inhalation injuries by focusing on pulmonary vascular permeability and cardiopulmonary function compared with those seen with either burn or smoke inhalation injury alone. To estimate the effect of factors other than injury, the experiments were also performed with no injury in the same experimental setting. Lung edema was most severe in the combined injury group. Our study revealed that burn injury does not affect protein leakage from the pulmonary microvasculature, even when burn is associated with smoke inhalation injury. The severity of lung edema seen with the combined injury is mainly due to augmentation of pulmonary microvascular permeability to fluid, not to protein. Cardiac dysfunction after the combined injury consisted of at least two phases. An initial depression was mostly related to hypovolemia due to burn injury. It was improved by a large amount of fluid resuscitation. The later phase, which was indicated to be a myocardial contractile dysfunction independent of the Starling equation, seemed to be correlated with smoke inhalation injury.

show abstract

Pathophysiology of Burn Injuries

Jeschke

Gauglitz

2019

Handbook of Burns Volume 1

View full text Add to dashboard Cite

Smoke Inhalation Injury Causes Myocardial Depression in Sheep

Cited by 9 publications

References 0 publications

Pathophysiology of burns

Pathophysiology of burns

Pathophysiological analysis of combined burn and smoke inhalation injuries in sheep

Pathophysiology of Burn Injuries

Contact Info

Product

Resources

About