Smoking and optic neuritis

Perkin, G D; Bowden, P. M. A.; Fc, Rose

doi:10.1136/pgmj.51.596.382

Cited by 10 publications

(8 citation statements)

References 22 publications

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“…This may result in accentuation of the cerebral symptoms such as mental confusion, blurred or double vision, vertigo and or ataxia, paresthesia, and motor weakness as well as general symptoms such as lassitude and fatigue 29. In a study assessing the effect of smoking on the recovery of visual function after an attack of optic neuritis (a common presentation of MS in which inflammation of the optic nerve causes unilateral painful blurring or loss of vision), heavy smokers were found to have a higher incidence of red/green color vision defects than nonsmokers 30. A transient worsening of upper extremity motor performance immediately after smoking has also been described in MS patients 31.…”

Section: Smoking and Acute Worsening Of Ms Symptomsmentioning

confidence: 99%

The effect of smoking on the symptoms and progression of multiple sclerosis: a review

Shirani

Tremlett²

2010

JIR

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Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disorder of the central nervous system with characteristic demyelinating lesions and axonal loss. MS accounts for the most common cause of neurological disability in young adults in the Western world. The clinical manifestations and the course of MS are highly variable. The early stage of the disease is usually characterized by attacks of neurological dysfunction with complete or incomplete recovery, however, with time disability accumulates in many patients. MS is believed to result from an interplay between susceptibility genes and environmental factors, one of which is smoking. Smoking, a worldwide epidemic, can be regarded as an important risk factor for MS particularly because of its modifiable nature in the quest to prevent or temper the disease course in MS as well as providing possible insights into MS pathogenesis. There are also reports that smoking may influence the symptoms and disease progression in patients with MS. The purpose of this article is to review the effects of smoking on MS symptoms and progression. We conclude that (1) although there are some early reports on worsening of MS symptoms by smoking, the existing evidence is insufficient to thoroughly assess the effects of smoking on the myriad of MS symptoms and (2) smoking seems to adversely influence disease progression in MS patients. We also discuss the potential biological mechanisms linking smoking and MS.

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Section: Smoking and Acute Worsening Of Ms Symptomsmentioning

confidence: 99%

The effect of smoking on the symptoms and progression of multiple sclerosis: a review

Shirani

Tremlett²

2010

JIR

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“…The high prevalence of occupational injury among active smokers could be explained by the following reasons. First, smoking is associated with blurred vision or hearing dysfunction 29 , 30 ) and may increase the chance of being injured. Second, active smokers may experience sleep problems, and they may also be more depressed, which may cause injury at work 31 , 32 ) .…”

Section: Discussionmentioning

confidence: 99%

Association of active and passive smoking with occupational injury in manual workers: a cross-sectional study of the 2011 Korean working conditions survey

et al. 2015

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This study was conducted to investigate the relationship of active and passive smoking with occupational injury among manual workers. Data from the 2011 Korean Working Conditions Survey were analyzed for 12,507 manual workers aged ≥15 yr. Overall, 60.4% of men and 5.8% of women were current smokers. The prevalence of injury was higher among never smokers who were exposed to secondhand smoke (SHS) (7.7% in men and 8.1% in women) than current smokers (4.2% in men and 4.1% in women). After controlling for potential confounders, in men, compared to those who never smoked and were not exposed to SHS, people who never smoked and were exposed to SHS (adjusted odds ratio (aOR)=3.7, 2.2–6.4) and current smokers (aOR=2.5, 1.6–3.8) were more likely to experience injury. Among women, the aORs of occupational injury were 8.4 (4.2–16.7) for never smoking women with occasional exposure to SHS and 3.5 (95% CI: 1.4–8.7) for current smokers, in comparison to never smoking women who were never exposed to SHS at work (reference group). The present study suggests that exposure to SHS is a possible risk factor of occupational injury for never smoking men and women.

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“…Aggravation of MS symptoms shortly after starting to smoke has been reported in several early studies [9,[30][31][32]. The relationship between smoking and disease progression is still arguable.…”

Section: Cigarette Smoking and The Clinical Course Of Msmentioning

confidence: 96%

The association between cigarette smoking and multiple sclerosis

Jafari

Hintzen

2011

Journal of the Neurological Sciences

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Genetic factors partially explain the susceptibility of multiple sclerosis (MS) and might even relate to the clinical course. Still, many epidemiological studies point at an important role for environmental factors in MS. Smoking is one of the major candidates. In this review we provide an overview of the epidemiological studies on cigarette smoking and the association on MS risk and MS clinical course. In addition, we discuss the possible biological pathways that may influence neurological damage in MS. Moreover, the relation of smoking with other environmental MS risk factors will be addressed.

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Smoking and optic neuritis

Cited by 10 publications

References 22 publications

The effect of smoking on the symptoms and progression of multiple sclerosis: a review

The effect of smoking on the symptoms and progression of multiple sclerosis: a review

Association of active and passive smoking with occupational injury in manual workers: a cross-sectional study of the 2011 Korean working conditions survey

The association between cigarette smoking and multiple sclerosis

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