Smoking Cessation Carries a Short-Term Rising Risk for Newly Diagnosed Diabetes Mellitus Independently of Weight Gain: A 6-Year Retrospective Cohort Study

Sung, Yi-Ting; Hsiao, C. C.; Chang, I-Jen; Lin, Yu-Chih; Yueh, Chen-Yu

doi:10.1155/2016/3961756

Cited by 23 publications

(11 citation statements)

References 55 publications

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“…The risk of incident diabetes (RR = 1.36) in ex-smokers who had quit for less than 5 years declined gradually to RR 1.23 in those who had stopped smoking between 5 and 9 years and declined to an almost equal risk of a non-smoker of RR 1.02 for those abstinent for over 10 years (RR = 1.02). In a retrospective study conducted on 8452 male T2DM patients in Taiwan [33], the RR was was 1.50 for smokers compared to non-smokers. Smoking abstinence contributed to increasing the risk for T2DM in the first year after quitting smoking (RR = 1.83) and in the second year (RR = 2.02), declining rapidly thereafter.…”

Section: Does Quitting Smoking Decrease the Incidence Of Diabetes?mentioning

confidence: 99%

Smoking and diabetes: dangerous liaisons and confusing relationships

Campagna

Alamo

Pino

et al. 2019

Diabetol Metab Syndr

148

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The combined harmful effects of cigarette smoking and hyperglycemia can accelerate vascular damage in patients with diabetes who smoke, as is well known. Can smoking cause diabetes? What are the effects of smoking on macro and microvascular complications? Now growing evidence indicates that regular smokers are at risk of developing incident diabetes. Since the prevalence rates of smoking in patients with diabetes are relatively similar to those of the general population, it is essential to address the main modifiable risk factor of smoking to prevent the onset of diabetes and delay the development of its complications. Quitting smoking shows clear benefits in terms of reducing or slowing the risk of cardiovascular morbidity and mortality in people with diabetes. Does quitting smoking decrease the incidence of diabetes and its progression? What are the effects of quitting smoking on complications? The current evidence does not seem to unequivocally suggest a positive role for quitting in patients with diabetes. Quitting smoking has also been shown to have a negative impact on body weight, glycemic control and subsequent increased risk of new-onset diabetes. Moreover, its role on microvascular complications of the disease is unclear. What are the current smoking cessation treatments, and which ones are better for patients with diabetes? Stopping smoking may be of value for diabetes prevention and management of the disease and its macrovascular and microvascular complications. Unfortunately, achieving long-lasting abstinence is not easy and novel approaches for managing these patients are needed. This narrative review examines the evidence on the impact of smoking and smoking cessation in patients with diabetes and particularly in type 2 diabetes mellitus and its complications. In addition, management options and potential future directions will be discussed.

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Section: Does Quitting Smoking Decrease the Incidence Of Diabetes?mentioning

confidence: 99%

Smoking and diabetes: dangerous liaisons and confusing relationships

Campagna

Alamo

Pino

et al. 2019

Diabetol Metab Syndr

148

View full text Add to dashboard Cite

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“…5 Additionally, smoking cessation generally decreases vascular risk for newly diagnosed diabetes mellitus. 96…”

Section: Smoking and Diabetes Complicationsmentioning

confidence: 99%

The impact of smoking on the development of diabetes and its complications

Śliwińska-Mossoń

Milnerowicz

2017

Diabetes and Vascular Disease Research

190

103

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Diabetes is one of the most common metabolic disorders and emerges secondary to an interaction between genetic, environmental and lifestyle factors. This work provides an overview of the impact of smoking on the development of vascular complications in this condition and also provides an overview of the potential role of smoking in predisposition to diabetes. There are many studies documenting the impact of smoking on health (not focused on patients with diabetes), suggesting that the health exposure in these individuals is at least comparable to that observed in the general population. Distinct studies of smoking in patients with diabetes have unambiguously confirmed an increased prevalence and a higher risk of early death associated with the development of macrovascular complications. Smoking is also associated with premature development of microvascular complications and may contribute to the pathogenesis of type 2 diabetes. It has been shown that smoking is a predictor of the progression of glucose intolerance at both the transition from normoglycaemia to impaired glucose tolerance status and the increased risk of developing diabetes. The mechanisms explaining the relationship between smoking and the development of diabetes are not fully understood, although a number of hypotheses have been put forward. Current evidence indicates that smoking cessation is not only important to prevent macrovascular complications in diabetes, but also has a role in limiting microvascular disease and may also facilitate glycaemic management in this condition.

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“…7 Cigarette smoking is independently associated with the incidence of T2DM. 24 Although the mechanisms involved are not clear yet. Smoking is associated with insulin resistance, inflammation and dyslipidaemia.…”

Section: Discussion Summary Of Resultsmentioning

confidence: 99%

“…A 14-year prospective cohort study in South Korea showed that the risk of DM among men and women who smoked 20 or more cigarettes a day was 1.55 times higher than that in non-smokers 7. Cigarette smoking is independently associated with the incidence of T2DM 24. Although the mechanisms involved are not clear yet.…”

Section: Discussionmentioning

confidence: 99%

Analysis of factors related to diabetic retinopathy in patients with newly diagnosed type 2 diabetes: a cross-sectional study

et al. 2020

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AimTo investigate the related factors of diabetic retinopathy (DR) and explore the correlation between smoking and DR in patients with newly diagnosed type 2 diabetes mellitus (T2DM).DesignA single-centre cross-sectional study.SettingTianjin 4th Central Hospital.ParticipantsPatients with newly diagnosed T2DM who visited the outpatient department of the hospital from December 2018 to April 2019.MethodsA total of 947 patients were enrolled in the study. They were divided into two groups according to whether they were diagnosed with DR (diabetic retinopathy group, DR group; non-diabetic retinopathy group, NDR group). The smoking index (SI) was calculated to assess smoking status. Factors such as sex, age, hypertension, T2DM diagnosed age, family history of diabetes, drinking history, haemoglobin A1c (HbA1c), body mass index (BMI) and smoking status were compared between the two groups. Logistic regression was used to analyse the relationship between DR and the above factors.ResultsThere was no statistically significant difference between the two groups in sex, age, hypertension, DM diagnosed age, family history of diabetes, drinking history and HbA1c. BMI was significantly higher in DR patients (27.7±4.2 vs 26.7±4.4, p=0.004). Smoking status was also different between the two groups (χ2=6.350, p=0.042). BMI was shown to be a related factor for DR in patients with newly diagnosed diabetes (OR=0.592, p=0.004). When BMI was ≥28 kg/m2, heavy smoking was significantly associated with DR (OR=2.219, p=0.049), and there was a negative correlation between DR and the age of diagnosis of diabetes ≥60 years (OR=0.289, p=0.009).ConclusionsHeavy smoking was an important related factor for DR in patients with newly diagnosed diabetes mellitus when BMI was ≥28 kg/m2. Delaying the age of diabetes might prevent the occurrence of DR. To elucidate the correlation, long-term cohort studies with large samples are needed.

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Smoking Cessation Carries a Short-Term Rising Risk for Newly Diagnosed Diabetes Mellitus Independently of Weight Gain: A 6-Year Retrospective Cohort Study

Cited by 23 publications

References 55 publications

Smoking and diabetes: dangerous liaisons and confusing relationships

Smoking and diabetes: dangerous liaisons and confusing relationships

The impact of smoking on the development of diabetes and its complications

Analysis of factors related to diabetic retinopathy in patients with newly diagnosed type 2 diabetes: a cross-sectional study

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