Smoking cessation in patients requiring bronchoscopy: The Bronchoscopy AntiSmoking Study (BASIS)

Martucci, Paola; Sestini, Piersante; Canessa, Pier Aldo; Brancaccio, L; Guarino, C.; Barbato, Natalino; Lodi, Marco; Coloretti, Isotta; Donno, Mario Del; Sini, A. M.; Cinti, Cristina; Melani, Andrea S.

doi:10.1016/j.rmed.2009.08.002

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…5). For example, the MAPKKs (MAP2K2 and MAP2K7) and PI3K, which are previously known to be associated with c-Met signaling, play a critical role in the regulation of brain endothelial cell migration by activating the extracellular signal regulated kinases, ERK1/2, JNKs and AKT1-3 [50] [51], respectively. These downstream kinases, which were also identified by our method, can now be linked to activating three previously unassociated kinases, PKA, eEF2K, and PKCD.…”

Section: Resultsmentioning

confidence: 99%

Profiling the Dynamics of a Human Phosphorylome Reveals New Components in HGF/c-Met Signaling

et al. 2013

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Protein phosphorylation is a dynamic and reversible event that greatly influences cellular function. Identifying the key regulatory elements that determine cellular phenotypes during development and oncogenesis requires the ability to dynamically monitor proteome-wide events. Here, we report the development of a new strategy to monitor dynamic changes of protein phosphorylation in cells and tissues using functional protein microarrays as the readout. To demonstrate this technology's ability to identify condition-dependent phosphorylation events, human protein microarrays were incubated with lysates from cells or tissues under activation or inhibition of c-Met, a receptor tyrosine kinase involved in tissue morphogenesis and malignancy. By comparing the differences between the protein phosphorylation profiles obtained using the protein microarrays, we were able to recover many of the proteins that are known to be specifically activated (i.e., phosphorylated) upon c-Met activation by the hepatocyte growth factor (HGF). Most importantly, we discovered many proteins that were differentially phosphorylated by lysates from cells or tissues when the c-Met pathway was active. Using phosphorylation-specific antibodies, we were able to validate several candidate proteins as new downstream components of the c-Met signaling pathway in cells. We envision that this new approach, like its DNA microarray counterpart, can be further extended toward profiling dynamics of global protein phosphorylation under many different physiological conditions both in cellulo and in vivo in a high-throughput and cost-effective fashion.

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Section: Resultsmentioning

confidence: 99%

Profiling the Dynamics of a Human Phosphorylome Reveals New Components in HGF/c-Met Signaling

et al. 2013

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Biomedical risk assessment as an aid for smoking cessation

Bize

Burnand

Müeller

et al. 2012

Cochrane Database of Systematic Reviews

102

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There is little evidence about the effects of most types of biomedical tests for risk assessment on smoking cessation. Of the fifteen included studies, only two detected a significant effect of the intervention. Spirometry combined with an interpretation of the results in terms of 'lung age' had a significant effect in a single good quality trial but the evidence is not optimal. A trial of carotid plaque screening using ultrasound also detected a significant effect, but a second larger study of a similar feedback mechanism did not detect evidence of an effect. Only two pairs of studies were similar enough in terms of recruitment, setting, and intervention to allow meta-analyses; neither of these found evidence of an effect. Mixed quality evidence does not support the hypothesis that other types of biomedical risk assessment increase smoking cessation in comparison to standard treatment. There is insufficient evidence with which to evaluate the hypothesis that multiple types of assessment are more effective than single forms of assessment.

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Biomedical risk assessment as an aid for smoking cessation

Clair

Müeller

Livingstone‐Banks

et al. 2019

Cochrane Database of Systematic Reviews

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We did not find evidence that giving smokers feedback on their smoking exposure, their genetic risk of smoking-related disease, or the e ects of smoking on their body helps them quit smoking. The most promising results were for giving people feedback on the harm smoking does to their bodies. The studies did not report on harms or side e ects of providing feedback. However, given the nature of the measurements (lung or blood tests), we would expect the risk of harms to be low. Certainty of evidence Because of problems with the way some of the studies were conducted, we think that further research is likely to change our conclusions.

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Smoking cessation in patients requiring bronchoscopy: The Bronchoscopy AntiSmoking Study (BASIS)

Cited by 3 publications

References 13 publications

Profiling the Dynamics of a Human Phosphorylome Reveals New Components in HGF/c-Met Signaling

Profiling the Dynamics of a Human Phosphorylome Reveals New Components in HGF/c-Met Signaling

Biomedical risk assessment as an aid for smoking cessation

Biomedical risk assessment as an aid for smoking cessation

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