Smoking cessation‐related weight gain—beneficial effects on muscle mass, strength and bone health

Rom, Oren; Reznick, Abraham Z.; Keidar, Zohar; Karkabi, Khaled; Aizenbud, Dror

doi:10.1111/add.12761

Cited by 32 publications

(20 citation statements)

References 45 publications

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“…Interestingly, a 60 day period of smoking cessation reversed these signaling alterations, including the upregulation of MuRF-1 and MAFbx, and soleus muscle weight (but not gastrocnemius) was normalized following smoking cessation [117]. In partial support, investigation of the effects of smoking versus smoking cessation on skeletal muscle demonstrated that a 12 months period of smoking cessation resulted in significant increases in muscle mass and strength in comparison with continued smoking [118]. Taking together, the role of MuRF-1 and MAFbx in muscle wasting in response to CS exposure has been demonstrated in several animal and in vitro studies.…”

Section: Cigarette Smokingmentioning

confidence: 92%

The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass

Rom

Reznick

2016

Free Radical Biology and Medicine

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186

143

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Section: Cigarette Smokingmentioning

confidence: 92%

The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass

Rom

Reznick

2016

Free Radical Biology and Medicine

Self Cite

186

143

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“…It will improve the overall nutritional status of the patient by eliminating the anorectic effect of tobacco, while reducing oxidative stress, lung and systemic inflammation and the negative protein balance, which are characteristic of COPD patients (149). In addition, it will prevent other deleterious effects of tobacco on muscle function and structure (150).…”

Section: To Stop Tobacco Smokingmentioning

confidence: 99%

Clinical management of chronic obstructive pulmonary disease patients with muscle dysfunction

et al. 2016

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Muscle dysfunction is frequently observed in chronic obstructive pulmonary disease (COPD) patients, contributing to their exercise limitation and a worsening prognosis. The main factor leading to limb muscle dysfunction is deconditioning, whereas respiratory muscle dysfunction is mostly the result of pulmonary hyperinflation. However, both limb and respiratory muscles are also influenced by other negative factors, including smoking, systemic inflammation, nutritional abnormalities, exacerbations and some drugs. Limb muscle weakness is generally diagnosed through voluntary isometric maneuvers such as handgrip or quadriceps muscle contraction (dynamometry); while respiratory muscle loss of strength is usually recognized through a decrease in maximal static pressures measured at the mouth. Both types of measurements have validated reference values. Respiratory muscle strength can also be evaluated determining esophageal, gastric and transdiaphragmatic maximal pressures although there is a lack of widely accepted reference equations. Non-volitional maneuvers, obtained through electrical or magnetic stimulation, can be employed in patients unable to cooperate. Muscle endurance can also be assessed, generally using repeated submaximal maneuvers until exhaustion, but no validated reference values are available yet. The treatment of muscle dysfunction is multidimensional and includes improvement in lifestyle habits (smoking abstinence, healthy diet and a good level of physical activity, preferably outside), nutritional measures (diet supplements and occasionally, anabolic drugs), and different modalities of general and muscle training.

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“…Exercise and nutritional interventions are important interventions for sarcopenia [ 14 ] and in rehabilitation after hip fracture [ 15 ]. Smoking cessation and reduction of harmful alcohol intake can possibly reduce sarcopenia [ 16 – 18 ] and the risk of hip fracture [ 19 – 22 ]. There is no consensus on how sarcopenia should be operationalized.…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia in patients with hip fracture: A multicenter cross-sectional study

Steihaug¹,

Gjesdal²,

Bogen³

et al. 2017

PLoS ONE

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BackgroundSarcopenia is prevalent in older persons and is a risk factor for falls, fractures, and mortality. The aim of this study was to determine a) the feasibility of determining sarcopenia in patients with acute hip fracture, b) the prevalence of sarcopenia and c) associations of sarcopenia with nutritional status and comorbidities.MethodsA multicenter cross-sectional study on sarcopenia in male and female patients with acute hip fracture. Participants were previously ambulatory and living in the community. Sarcopenia was assessed postoperatively with muscle mass estimated by anthropometry using triceps skinfold, arm circumference, height, weight and sex. Grip strength was measured by Jamar dynamometer and pre-fracture mobility was by self-report using the New Mobility Score.ResultsOut of 282 patients, 202 were assessed for sarcopenia of whom 74 (37%) were diagnosed as sarcopenic. Sarcopenia was associated with age, odds ratio (OR) 1.4 per 5 years, 95% confidence interval (CI) [1.1, 1.8], ASA Physical Status Classification System score, OR 2.3 per point, 95% CI [1.3, 4.3] and number of medications at discharge, OR 1.2 per medication, 95% CI [1.0, 1.3] and inversely associated with BMI, OR 0.8, 95% CI [0.7, 0.9] and serum albumin, OR 0.9, 95% CI [0.8,1.0].ConclusionsThirty-seven percent of assessed subjects were diagnosed with sarcopenia. Our data demonstrates that the prevalence of sarcopenia is associated with older age, malnutrition and comorbidities. Determining sarcopenia at the bedside was feasible in postoperative hip fracture patients by using grip strength, estimation of muscle mass by anthropometry and self-reported mobility.

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Smoking cessation‐related weight gain—beneficial effects on muscle mass, strength and bone health

Abstract: Smoking cessation is associated with weight gain mainly through accumulating extra fat, but is also associated with increased muscle mass, muscle strength and bone density.

Cited by 32 publications

References 45 publications

The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass

The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass

Clinical management of chronic obstructive pulmonary disease patients with muscle dysfunction

Sarcopenia in patients with hip fracture: A multicenter cross-sectional study

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