BackgroundThe climate change manifestations are associated with dramatic consequences for human health and threat physical activity behaviors.ObjectiveThe aims of this systematic review were to present the potential bidirectional associations between climate change consequences and physical activity (PA) behaviors in human and to propose the first synthesis of the literature through a conceptual model of climate change and PA. MethodsStudies published before October 2019, were identified through database searches in Pubmed, PsycArticles, CINAHL, SportDiscus, GreenFILE and GeoRef. Studies examining the associations between PA domains and climate change (e.g., natural disaster, air pollution, carbon footprint) were included.ResultsA narrative synthesis was performed and the 63 identified articles were classified into 6 topics: air pollution and PA, extreme weather conditions and PA, greenhouse gas emissions and PA, carbon footprint among sport participants, natural disasters and PA and the future of PA and sport practices in a changing world. Then, a conceptual model was proposed to identify the multidimensional associations between climate change and PA as well as sport practices. The results indicated a consistent negative effect of air pollution, extreme temperatures and natural disasters on PA levels. This PA reduction will be more severe in adults with chronic diseases, higher body mass index and elderly. The sport and PA communities can play an important mitigation role in post-natural disaster contexts. However, transport related to sport practices are also a source of greenhouse gas emissions.ConclusionThe climate change consequences increasingly and disproportionately impact PA at worldwide scale. PA has two concurrent mitigation and amplification roles towards climate changes.