Smoking Patterns in Cancer Survivors

Mayer, Deborah K.; Carlson, John R.

doi:10.1093/ntr/ntq199

Cited by 71 publications

(81 citation statements)

References 28 publications

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“…However, cervical cancer survivors may face an increased risk of a subsequent tobacco-related cancer diagnosis due to prior treatment [37], and their high prevalence of persistent smoking after a cancer diagnosis [9,10]. According to our findings, cervical cancer survivors have a higher risk of a subsequent tobacco-related cancer diagnosis (including stomach, esophageal, lung and pancreatic cancer), when compared to the risk among other cancer survivors.…”

Section: Discussionmentioning

confidence: 46%

“…However, some unhealthy behaviors which are associated with increased cancer risk have often been reported among this group. Cervical cancer survivors have been shown to smoke and consume more alcohol than other cancer survivors; [9,10] each of these behaviors are linked to increased cancer risk among survivors [32], and may be related to the increased risk of subsequent malignancies, including subsequent tobaccorelated malignancies observed in this report.…”

Section: Discussionmentioning

confidence: 99%

“…Along with cervical cancer, esophageal, head and neck, and oral cancer are also related to HPV infection [24] and tobacco use [12]. HPV infection has been shown to have a synergistic effect with cigarette smoking [25], and cervical cancer survivors have a higher smoking prevalence compared with other cancer survivors [9,10]. It may be that HPV-induced susceptibility to cancer, in addition to a high smoking prevalence, contributes to the increased risk of subsequent tobacco-related malignancies among cervical cancer survivors.…”

Section: Discussionmentioning

confidence: 99%

“…The estimated smoking prevalence among cervical cancer survivors exceeds 40 % compared with 14 % among breast cancer survivors, 12 % among colorectal cancer survivors [9,10], and 18 % among the general population of US women [11]. The comparably high smoking prevalence reported among cervical cancer survivors may increase their risk of subsequent malignancies, especially for cancers related to tobacco use [11].…”

Section: Introductionmentioning

confidence: 99%

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Cervical cancer survivors at increased risk of subsequent tobacco-related malignancies, United States 1992–2008

Underwood

Rim

Fairley

et al. 2012

Cancer Causes Control

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Purpose-Persistent smoking among cancer survivors may increase their risk of subsequent malignancies, including tobacco-related malignancies. Despite these risks, nearly 40 % of women diagnosed with cervical cancer continue to smoke after diagnosis. This study describes the relative risk of developing any subsequent and tobacco-related malignancy among cervical cancer survivors.Methods-We examined data from the year 1992 to 2008 in 13 Surveillance, Epidemiology and End Results registries. We calculated the standardized incidence ratio (SIR) and 95 % confidence limits (CLs) for all subsequent and tobacco-related malignancies among cervical cancer survivors. Tobacco-related malignancies were defined according to the 2004 Surgeon General's Report on the Health Consequences of Smoking. For comparison with cervical cancer survivors, SIRs for subsequent malignancies were also calculated for female survivors of breast or colorectal cancers.Results-The SIR of developing a subsequent tobacco-related malignancy was higher among cervical cancer survivors (SIR = 2.2, 95 % CL = 2.0-2.4). Female breast (SIR = 1.1, 95 % CL = 1.0-1.1) and colorectal cancer survivors (1.1, 1.1-1.2) also had an elevated risk. The increased risk of a subsequent tobacco-related malignancy among cervical cancer survivors was greatest in the first 5 years after the initial diagnosis and decreased as time since diagnosis elapsed.Conclusion-Women with cervical cancer have a two-fold increased risk of subsequent tobacco-related malignancies, compared with breast and colorectal cancer survivors. In an effort to decrease their risk of subsequent tobacco-related malignancies, cancer survivors should be targeted for tobacco prevention and cessation services. Special attention should be given to cervical cancer survivors whose risk is almost twice that of breast or colorectal cancer survivors.

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Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cervical cancer survivors at increased risk of subsequent tobacco-related malignancies, United States 1992–2008

Underwood

Rim

Fairley

et al. 2012

Cancer Causes Control

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“…43 Kinoshita et al 21 observed that subjects with gastric cancer who continued to smoke had a 3-fold risk of developing a second smoking-related malignancy. Also, subjects who survived small-cell lung cancer for Ͼ 2 y and continued to smoke had a 7-fold increased risk for a second smoking-related malignancy.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Smoking Cessation in Subjects With Cancer: A 30-Year Review

Florou¹,

Gkiozos

Tsagouli

et al. 2014

Respir Care

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BACKGROUND: Despite the established causal relationship between tobacco smoking and cancer, many cancer patients continue to smoke after diagnosis. This partly reflects ignorance of the beneficial effects of smoking cessation, even after diagnosis. The aim of this study was to demonstrate the effects of continuing or quitting smoking in patients with diagnosed cancer. METHODS: The study was based on a review of medical databases (PubMed Central, MEDLINE, Cochrane Library) in the last 30 y. All articles included in the present analysis were in English. RESULTS: In subjects with early-stage lung cancer, continued smoking after diagnosis is associated with an increased risk of all-cause mortality and decreased survival. Research has demonstrated significant differences in actuarial overall survival favoring the non-smoking group among subjects with lung cancer. In subjects with oral cancer, smoking cessation or reduction leads to a significant reduction in mortality. There is also evidence that tobacco smoking aggravates and prolongs radiotherapyinduced complications. Of particular importance is evidence that continued smoking is associated with adverse effects during anti-cancer treatment. Smoking promotes tumor progression and increases resistance to chemotherapy due to nicotine-induced resistance to apoptosis by modulating mitochondrial signaling. Continued smoking is also related to inferior outcomes of treatment with novel targeted therapies such as erlotinib. Smoking in subjects with gastric and lung cancer is also associated with an increased risk of developing second primary tumors. Quitting smoking after lung cancer diagnosis is associated with a better performance status, whereas persistent smokers have worse overall quality of life. Subjects who continue to smoke despite being diagnosed with cancer report more severe pain than subjects who have never smoked and greater pain-related functional impairment. CONCLUSIONS: Continued smoking after cancer diagnosis is related to reduced treatment efficacy and reduced survival, increased risk for second primary malignancies, and deterioration of quality of life.

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Continued smoking in African American cancer survivors: The Detroit Research on Cancer Survivors Cohort

et al. 2020

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Smoking Patterns in Cancer Survivors

Cited by 71 publications

References 28 publications

Cervical cancer survivors at increased risk of subsequent tobacco-related malignancies, United States 1992–2008

Cervical cancer survivors at increased risk of subsequent tobacco-related malignancies, United States 1992–2008

Clinical Significance of Smoking Cessation in Subjects With Cancer: A 30-Year Review

Continued smoking in African American cancer survivors: The Detroit Research on Cancer Survivors Cohort

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