Smoking-related microRNAs and mRNAs in human peripheral blood mononuclear cells

Su, Ming-Wei; Yu, Shan‐Fu; Lin, Wen-Chiao; Tsai, Ching-Hui; Chen, Po-Hua; Lee, Yungling Leo

doi:10.1016/j.taap.2016.06.020

Cited by 18 publications

(18 citation statements)

References 40 publications

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“…Together with miR-6086 and miR-6088, miR-6087 is found at high levels in undifferentiated embryonic stem cells, and their expression is lowered during endothelial differentiation (45). Other miRNAs relevant for melanoma pathogenesis include miR-4498, which was isolated at higher levels from hypoxic exosomes and might influence immune responses by targeting CD83, an immunostimulatory molecule critical for the activation of T-cells (46). miR-21, which we found in both normoxic and hypoxic exosomes, was described as promoting a pro-metastatic phenotype when delivered to normoxic oral squamous cell carcinoma cells by increasing snail family transcriptional repressor 1 (SNAI1) and vimentin expression (47).…”

Section: Discussionmentioning

confidence: 99%

Analysis of the miRNA Profiles of Melanoma Exosomes Derived Under Normoxic and Hypoxic Culture Conditions

Wozniak

Pęczek

Czernek

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Analysis of the miRNA Profiles of Melanoma Exosomes Derived Under Normoxic and Hypoxic Culture Conditions

Wozniak

Pęczek

Czernek

et al. 2017

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“…The immunosuppressive effect was mediated by miR-23a, in addition to TGF-β (Berchem et al 2015). MiR-4498 showed higher levels in hypoxic exosomes isolated from melanoma cells (own unpublished results) and might influence immune responses by targeting CD83, an immunostimulatory molecule critical for the activation of T cells (Su et al 2016). In murine tumor models, mir-494 was shown to regulate the activity of MDSC (myeloid-derived suppressor cells), a major type of immunosuppressive cells (Liu et al 2012).…”

Section: The Functions Of Cancer-derived Exosomes In Immunosuppressionmentioning

confidence: 99%

“…A similar activity was attributed to miR-494 that inhibited macrophage polarization and switched them towards the immunosuppressive M2 type (Zhao et al 2016). In a co-culture system of murine cell lines, pancreatic cancer cell-derived exosomes shifted macrophage polarization to the M2 phenotype (Su et al 2016). Over-expression of miR-155 and miR-125b-2 in the cancer cells reverted this effect and resulted in M1 polarized macrophages upon exosome exposure.…”

Section: The Functions Of Cancer-derived Exosomes In Immunosuppressionmentioning

confidence: 99%

Functions of Cancer-Derived Extracellular Vesicles in Immunosuppression

Czernek

Duechler

2017

Arch. Immunol. Ther. Exp.

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Extracellular vesicles, including exosomes, constitute an important element of intercellular communication by carrying a variety of molecules from producer to target cells. The transport of mRNA and miRNA can directly modulate gene expression in the target cells. The miRNA content in exosomes is characteristic for the cell from which the vesicles were derived enabling the usage of exosomes as biomarkers for the diagnosis various diseases, including cancer. Cancer-derived exosomes support the survival and progression of tumors in many ways and also contribute to the neutralization of the anti-cancer immune response. Exosomes participate in all known mechanisms by which cancer evades the immune system. They influence the differentiation and activation of immune suppressor cells, they modulate antigen presentation, and are able to induce T-cell apoptosis. Although cancer-derived exosomes mainly suppress the immune system and facilitate tumor progression, they are also important sources of tumor antigens with potential clinical application in stimulating immune responses. This review summarizes how exosomes assist cancer to escape immune recognition and to acquire control over the immune system.

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“…In addition, increased levels of miR-4498 were observed in hypoxic T-EVs derived from melanoma cells [ 35 ]. CD83, which is a key in the communication between cells of the innate and adaptive immune response, is regulated by miR-4498 [ 56 ].…”

Section: Immunosuppression By Cancer-derived Extracellular Vesiclesmentioning

confidence: 99%

Cancer-derived extracellular vesicles: friend and foe of tumour immunosurveillance

Dörsam

Reiners

Strandmann

2017

Phil. Trans. R. Soc. B

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Extracellular vesicles (EVs) are important players of intercellular signalling mechanisms, including communication with and among immune cells. EVs can affect the surrounding tissue as well as peripheral cells. Recently, EVs have been identified to be involved in the aetiology of several diseases, including cancer. Tumour cell-released EVs or exosomes have been shown to promote a tumour-supporting environment in non-malignant tissue and, thus, benefit metastasis. The underlying mechanisms are numerous: loss of antigen expression, direct suppression of immune effector cells, exchange of nucleic acids, alteration of the recipient cells' transcription and direct suppression of immune cells. Consequently, tumour cells can subvert the host's immune detection as well as suppress the immune system. On the contrary, recent studies reported the existence of EVs able to activate immune cells, thus promoting the tumour-directed immune response. In this article, the immunosuppressive capabilities of EVs, on the one hand, and their potential use in immunoactivation and therapeutic potential, on the other hand, are discussed.This article is part of the discussion meeting issue ‘Extracellular vesicles and the tumour microenvironment’.

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Smoking-related microRNAs and mRNAs in human peripheral blood mononuclear cells

Cited by 18 publications

References 40 publications

Analysis of the miRNA Profiles of Melanoma Exosomes Derived Under Normoxic and Hypoxic Culture Conditions

Analysis of the miRNA Profiles of Melanoma Exosomes Derived Under Normoxic and Hypoxic Culture Conditions

Functions of Cancer-Derived Extracellular Vesicles in Immunosuppression

Cancer-derived extracellular vesicles: friend and foe of tumour immunosurveillance

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