Smoking status is associated with mild cognitive impairment assessed with the mini-mental state examination in Japanese diabetic patients

Sonoda, Nao; Morimoto, Akira; Ugi, Satoshi; Morino, Katsutaro; Sato, Osamu; Nemoto, Koji; Maegawa, Hiroshi; Miyamatsu, Naomi

doi:10.1007/s13340-016-0256-0

Cited by 9 publications

(6 citation statements)

References 30 publications

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“…Although there is inconsistency for the gender differences for the incidence rate of cognitive impairment, however, more studies have reported a higher prevalence of cognitive impairment in women [ 22 – 24 ]. Our study also showed that smoking and glycated hemoglobin were strongly associated with cognitive impairment in patients with T2DM, the results are consistent with previous reports [ 25 , 26 ].…”

Section: Discussionsupporting

confidence: 93%

The association between blood lipids and cognitive impairment in type 2 diabetes mellitus

Ma,

Yuan,

Cheng

et al. 2024

Eur J Med Res

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Objective The study was performed to explore the association between blood lipids and cognitive impairment in patients with type 2 diabetes mellitus (T2DM). Methods This study included 336 patients with T2DM. Relevant clinical data including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), apolipoprotein A1, apolipoprotein B were collected, and the Mini-Mental State Examination (MMSE) score and Montreal Cognitive Assessment (MoCA) score were used to assess the cognitive function in patients with T2DM. Results Serum apolipoprotein A1 levels were significantly increased in T2DM patients with cognitive impairment compared with T2DM patients without cognitive impairment (p = 0.017). Serum apolipoprotein A1 levels were significantly negatively correlated with MoCA score (r = − 0.143, p = 0.009) and MMSE score (r = − 0.132, p = 0.016) in patients with T2DM. In multivariable-adjusted regression model, serum apolipoprotein A1 was independently associated with cognitive impairment in patients with T2DM (OR = 5.201, p = 0.024). Conclusion Serum apolipoprotein A1 is associated with cognitive impairment in patients with T2DM, but not TC, TG, HDL-C, LDL-C, and apolipoprotein B, indicating that increased serum apolipoprotein A1 may be a risk factor of cognitive impairment in patients with T2DM.

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Section: Discussionsupporting

confidence: 93%

The association between blood lipids and cognitive impairment in type 2 diabetes mellitus

Ma,

Yuan,

Cheng

et al. 2024

Eur J Med Res

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“…Both AC and WC were predictors of cognitive performance in women and men, but BMI was only a predictor in women. On multivariate analysis for age, smoking status (27–29), and BMI or WC or AC values, all three body measurements remained significant predictors of cognitive performance in women (p<0.001, p=0.003, p<0.001, respectively). In men, only BMI (p=0.013) and AC (p<0.001) were independent predictors.…”

Section: Resultsmentioning

confidence: 98%

Obesity Paradox in Caucasian Seniors: Results of the PolSenior Study

Puzianowska-Kuźnicka

Kuryłowicz

Walkiewicz

et al. 2019

The Journal of nutrition, health and aging

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Objectives To investigate the influence of overweight and obesity on general performance and mortality in seniors. Design Cross-sectional multidisciplinary study on ageing of the Polish population. Setting Community-dwelling individuals aged 65 years or older, selected using three-stage stratified, proportional draw. Participants 4944 Polish Caucasian seniors, aged 65 years or older recruited between October 2007 and October 2010. Measurements All study subjects underwent measurement of body mass index (BMI), waist circumference (WC), and arm circumference (AC). The physical and cognitive performance was evaluated using the Katz Activities of Daily Living (ADL) score and Mini-Mental State Examination (MMSE), respectively. Morbidity data were obtained from a medical questionnaire. Mortality data were obtained from the Population Register of Poland between October 2015 and October 2018. Results Increasing age was associated with a decreased prevalence of obesity (all p<0.001). Higher BMI, WC and AC values were associated with higher ADL and MMSE scores (all p<0.001). On multivariate analysis, all three body measurements in women remained independent predictors of the ADL score (BMI p=0.002, WC p=0.005, AC p<0.001) and MMSE score (p<0.001, p=0.003, p<0.001). In men, physical functioning was associated with AC (p=0.003), and cognitive status was associated with AC (p<0.001) and BMI (p=0.013). There was no association between general obesity, abdominal obesity, or AC with several aging-related adverse conditions. Kaplan-Meier survival curves showed that overweight and obesity were associated with the lowest mortality. On multivariate analysis, BMI and AC values remained independent predictors of mortality. In successfully aging individuals, neither BMI, WC, nor AC remained such predictors. Conclusions Overweight and obesity in Caucasian seniors are not associated with deterioration of physical and cognitive function or with increased mortality.

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“…The correlation of the WC with an ADL score was also extremely weak in both sexes together and in men ( r s = 0.04, p < 0.01; r s = 0.09, p < 0.001, respectively), while in women no correlation existed. Next, we performed the multivariable analysis with age, sex, and smoking status as co-variates selected based on the literature data [ 34 , 35 , 36 ]. The analysis revealed that both body measurements remained independent predictors of an ADL score (BMI: p < 0.001, WC: p < 0.05).…”

Section: Resultsmentioning

confidence: 99%

Obesity in Caucasian Seniors on the Rise: Is It Truly Harmful? Results of the PolSenior2 Study

et al. 2022

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Obesity is associated with an increased risk of morbidity and mortality; however, data suggest that in old age, obesity is not detrimental. The study’s objective was to verify whether obesity frequency still increases in Polish Caucasian seniors and to verify the “obesity paradox”. Five thousand and fifty-seven community-dwelling individuals aged ≥ 65 years completed a detailed medical questionnaire, underwent measurements of the body mass index (BMI) and the waist circumference (WC), and an evaluation of physical and cognitive performances. Over a decade, general obesity increased by 2.1%, mostly due to a 3.9% increase in men. Abdominal obesity increased by 1.0%, mainly due to males, in whom it increased by 3.9%. Obesity increased the risk of several aging-related diseases, but this effect was less pronounced in the oldest-old. Obesity did not adversely affect the physical and cognitive functioning or mortality. Through a multivariable analysis, the BMI and WC remained the independent predictors of the Katz Activities of Daily Living score (p < 0.001 and p < 0.05, respectively) and Mini-Mental State Examination score (both p < 0.001). The Kaplan–Meier survival curves revealed that overweight and obesity classes 1 and 2 were associated with the lowest mortality. Through a multivariable analysis, overweight, class 1 obesity, and abdominal obesity remained the independent predictors of a decreased mortality (all p < 0.001). In conclusion, we found that overweight and obesity are not detrimental in seniors, including the oldest-old. We suggest that the anthropometric values defining obesity should be modified for age-advanced people.

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Smoking status is associated with mild cognitive impairment assessed with the mini-mental state examination in Japanese diabetic patients

Cited by 9 publications

References 30 publications

The association between blood lipids and cognitive impairment in type 2 diabetes mellitus

The association between blood lipids and cognitive impairment in type 2 diabetes mellitus

Obesity Paradox in Caucasian Seniors: Results of the PolSenior Study

Obesity in Caucasian Seniors on the Rise: Is It Truly Harmful? Results of the PolSenior2 Study

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