Smooth muscle antibodies and alopecia areata

Main, Robert; Robbie, Rosalene B.; Gray, Elizabeth; Donald, David C.; Horne, C. H. W.

doi:10.1111/j.1365-2133.1975.tb03098.x

Cited by 70 publications

(29 citation statements)

References 11 publications

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“…Workers who are in contact with phenolic derivatives have been reported to develop vitiligo in a high percentage (27.2-44.4%) [8][9][10][11], whereas the percentage of vitiligo de velopment in our patients is low (6.7%) and similar to that found in patients with alope cia areata (4-8.9%) [4][5][6]. Moreover, vitiligo as a side effect of diphencyprone treatment has not been observed to our knowledge by other investigators who have also used diphencyprone for therapeutical purposes [1][2][3].…”

Section: Discussionmentioning

confidence: 49%

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Vitiligo as a Reaction to Topical Treatment with Diphencyprone

et al. 1988

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During the topical treatment of 45 patients, who had extensive forms of alopecia areata, with the allergen diphencyprone, 3 of them (6.7%) developed vitiligo. Two were females and 1 male aged 53, 19 and 28 years respectively. None of these patients had a personal or family history of vitiligo. Vitiligo appeared 3–5 months after the onset of treatment and was localized only to the areas of topical application in the younger woman and the man. In the older woman, vitiligo extended to several areas apart from those where the medicament was applied. After the end of diphencyprone treatment, vitiligo had a spontaneous significant improvement only in the man. Mitochondrial autoantibodies were found in the older woman only. To our knowledge, vitiligo due to diphencyprone has not been previously reported.

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Section: Discussionmentioning

confidence: 49%

“…The incidence of vitiligo in patients with alopecia areata is higher than in the general population and ranges from 4 to 8.9% [4][5][6], Fig. 1.…”

Section: Discussionmentioning

confidence: 99%

Vitiligo as a Reaction to Topical Treatment with Diphencyprone

et al. 1988

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“…In autoimmune polycndocrinopathy 30% of the patients develop AA [9] and an association between A A. Hashimoto's disease and myasthenia gravis has been repeatedly reported [ 1,10,111. Many authors described autoantibodies against thyroglobulin, parietal cells, adrenal cells and smooth muscle cells in the peripheral blood of AA patients [12,13]; nevertheless their relevance to the disease is still unclear. 1 listologically AA is characterized by the accumulation of lymphocytes, especially pronounced in the active phase of the disease; this infiltrate predominantly consists of CD4-positivc cells with a CD4/CD8 ratio of approximately 4:1 [14,15].…”

Section: Discussionmentioning

confidence: 99%

Alopecia areata and lnterleukin-2 Receptor

Valsecchi

Imberti²,

Martino³

et al. 1992

Dermatology

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Interleukin-2 (IL-2) is a lymphokine produced by activated T cells and its receptor (IL-2R) is expressed on T cells; one of the IL-2R components can be measured as a soluble serum protein (sIL-2R). Levels of sIL-2R were measured as a sign of T cell activation in serum of 12 patients suffering from alopecia areata (totalis or universalis) and in a group of healthy control subjects. An enzyme-linked immunosorbent assay was used to determine the levels of sIL-2R in blood samples drawn during both the active and resting phase of the disease. In patients with alopecia areata in active phase the sIL-2R concentrations were significantly higher than in stable phase and in controls. The biologic role of sIL-2R is still unknown, but one could speculate that T lymphocyte activation with subsequent secretion of IL-2 and IL-2R expression may contribute to the immune inflammatory mechanism of alopecia areata.

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“…AA'ya SLE ve diskoid lupus eritematozus (DLE) eşlik edebilmektedir. ANA pozitifliği ise %0-20,4 arasında bildirilmiştir (6,7,16,(22)(23)(24)(25). Bizim çalışmamızda %0,7 DLE, %9,2 ANA pozitifliği saptandı.…”

Section: Bulgularunclassified

Presence of Autoimmune Diseases in Alopecia Areata Patients and Their Families and Its Effect on Prognosis

Duman¹,

Köse²,

İşsever³

2016

tdd

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Amaç: Alopesi areatada (AA), etyopatogenezde otoimmünitenin rolünü ve eşlik eden otoimmün hastalıkların prognoz üzerindeki etkilerini araştırmayı amaçladık. Yöntemler: Deri ve zührevi hastalıklar polikliniğine başvurmuş 134 hasta, ailesinde otoimmün hastalık öyküsü ve AA'ya eşlik eden otoimmün hastalık varlığı açısından retrospektif olarak incelendi. Bulgular: Çalışmaya alınan 134 olgunun 79'u erkek (%59), 55'i kadın (%41) idi. Araştırmada %16,4 oranında otoimmün hastalık saptandı. Otoimmün hastalık, kadınlarda (p=0,034) ve ailede otoimmün hastalık öyküsü olanlarda (p=0,011) yüksek bulundu. Otoimmün hastalık birlikteliği ile hastalık süresi, hastalık tipi, hastalık şiddeti, hastalık başlangıç yaşı, tırnak tutulumu, atopi, nevüs flammeus varlığı ve ailede AA öyküsü arasındaki ilişki anlamsızdı. AA'lı ailelerde otoimmün hastalık öyküsü %16,4 idi. Sonuç: AA'lı hem hasta hem de hasta ailelerinde otoimmün hastalık oranının yüksek saptanması, otoimmün hastalığın kadınlarda belirgin yüksekliği, AA'nın bir otoimmün hastalık olabileceği tezini desteklemektedir. Ayrıca otoimmün hastalığın varlığı AA'da kötü prognoza yol açmamaktadır. Objective: We aimed to investigate the role of autoimmunity in the etiopathogenesis of alopecia areata (AA) and the effects of the coexisting autoimmune diseases on the prognosis of AA. Methods: The records of 134 AA patients diagnosed in the dermatology and venereology outpatient clinic were retrospectively analyzed for the history of concomitant autoimmune disease and the family history for autoimmune diseases.

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Smooth muscle antibodies and alopecia areata

Abstract: In seventy-eight patients with alopecia areata, the incidence of auto-antibodies to smooth muscle was greater than that in an age and sex matched control population.

Cited by 70 publications

References 11 publications

Vitiligo as a Reaction to Topical Treatment with Diphencyprone

Vitiligo as a Reaction to Topical Treatment with Diphencyprone

Alopecia areata and lnterleukin-2 Receptor

Presence of Autoimmune Diseases in Alopecia Areata Patients and Their Families and Its Effect on Prognosis

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