Smooth muscle contribution to vaginal viscoelastic response

Clark-Patterson, Gabrielle L.; Buchanan, Lily M.; Ogola, Benard O.; Florian-Rodriguez, Maria; Lindsey, Sarah H.; Vita, R. De; Miller, Kristin S.

doi:10.1016/j.jmbbm.2023.105702

Cited by 9 publications

(17 citation statements)

References 59 publications

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“…These contractions are believed to be mediated by cholinergic nerves (muscarinic acetylcholine receptor M3), indicating the involvement of neurotransmitter release in modulating smooth muscle contractility [ 62 ]. Furthermore, the electrical properties of VSM contribute to its viscoelastic response, with smooth muscle contraction leading to changes in vaginal creep behavior, highlighting the dynamic nature of electrical activities in regulating tissue mechanics [ 6 ]. The membrane potential, primarily controlled by ion channel activity, is a critical determinant of cellular excitability and contractility in VSM cells.…”

Section: Membrane Potential In Smooth Muscle Contractionmentioning

confidence: 99%

“…Furthermore, methodologies, such as inflation-extension testing, provide a comprehensive evaluation of vaginal tissue mechanics and contractility. Utilizing in vivo pressure measurements and biaxial testing, studies have explored the viscoelastic properties and contractile behavior of vaginal smooth muscle [ 6 ]. These experimental approaches enable the characterization of mechanical properties and responses to various stimuli, shedding light on the physiological and pathological mechanisms underlying vaginal function.…”

Section: Experimental and Computational Techniques For Studying Vsm C...mentioning

confidence: 99%

“…Ca 2+ influx is a key determinant of VSM contraction, facilitated through voltage-dependent Ca 2+ channels (VDCC) and Ca 2+ release from intracellular stores [ 2 ]. The value of intracellular Ca 2+ concentration is modulated by the coordinated action of ion channels, neurotransmitters, and hormonal signals, leading to cyclic changes in vaginal tone and elasticity [ 6 , 8 , 9 ]. During sexual arousal, pelvic nerve stimulation triggers the relaxation of vaginal smooth muscles, facilitating intercourse [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Such alterations can profoundly impact vaginal health and function. For instance, a disorder of smooth muscle contraction can lead to an increase in vaginal creep behavior, affecting the viscoelastic response of the vagina, crucial for maintaining structural integrity under prolonged pressure [ 6 ]. Additionally, deformations in the vagina resulting from these contractions are pivotal in the onset of pelvic floor disorders, necessitating a deeper understanding of these changes to address their root causes [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Biophysical Mechanisms of Vaginal Smooth Muscle Contraction: The Role of the Membrane Potential and Ion Channels

Mahapatra,

Kumar

2024

Pathophysiology

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The vagina is an essential component of the female reproductive system and is responsible for providing female sexual satisfaction. Vaginal smooth muscle contraction plays a crucial role in various physiological processes, including sexual arousal, childbirth, and urinary continence. In pathophysiological conditions, such as pelvic floor disorders, aberrations in vaginal smooth muscle function can lead to urinary incontinence and pelvic organ prolapse. A set of cellular and sub-cellular physiological mechanisms regulates the contractile properties of the vaginal smooth muscle cells. Calcium influx is a crucial determinant of smooth muscle contraction, facilitated through voltage-dependent calcium channels and calcium release from intracellular stores. Comprehensive reviews on smooth muscle biophysics are relatively scarce within the scientific literature, likely due to the complexity and specialized nature of the topic. The objective of this review is to provide a comprehensive description of alterations in the cellular physiology of vaginal smooth muscle contraction. The benefit associated with this particular approach is that conducting a comprehensive examination of the cellular mechanisms underlying contractile activation will enable the creation of more targeted therapeutic agents to control vaginal contraction disorders.

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Section: Membrane Potential In Smooth Muscle Contractionmentioning

confidence: 99%

Section: Experimental and Computational Techniques For Studying Vsm C...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biophysical Mechanisms of Vaginal Smooth Muscle Contraction: The Role of the Membrane Potential and Ion Channels

Mahapatra,

Kumar

2024

Pathophysiology

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“…Smooth muscle content of the vaginal wall appears to be reduced in postmenopausal women 16,17 . Basic science investigations are in progress to determine how smooth muscle contractility affects the viscoelastic properties of the vagina, 18,19 but these have not yet addressed hormonally induced changes. In contrast to our clinical impression, in vitro elasticity of the vagina was shown to be greater, not less, in untreated ovariectomized rats compared with those treated with estrogen 20 .…”

mentioning

confidence: 99%