Smooth Muscle Relaxing, Acute and Long-Term Blood Pressure Lowering Effects of Atriopeptins

Mey, Jörg; Malder, G van; Cuthbert, Colleen; Calderón, Pablo Sánchez

doi:10.1097/00005344-198611000-00112

Cited by 2 publications

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“…For the past several years much effort has been expended to discover a therapeutically useful ana- 23 However, other reports have noted a transient antihypertensive effect of atriopeptin infusion. In two-kidney, one clip hypertensive rats atriopeptin infusion lowered systolic pressure gradually over the first 5 days, but systolic pressure returned to control group level over the following 7 days.…”

Section: Discussionmentioning

confidence: 99%

Chronic atriopeptin regulation of arterial pressure in conscious hypertensive rats.

et al. 1990

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Acute coadministrations of an inhibitor of endopeptidase 24.11 (thiorphan) and a ligand (SC-46542) selective for the non-guanylate cyclase-llnked atriopeptin binding sites increases urinary sodium excretion to a greater degree in conscious spontaneously hypertensive rats than in normotensive Wistar-Kyoto rats. In the present study, we examined the effects of chronic 10-day intravenous infusions of SC-46542 (desIPhe'^Gly'^Ala^Gln" 6 ] atriopeptin-(103-126)) (0.1 mg/kg/hr), thiorphan (1.5 mg/kg/hr), and atriopeptin-(103-126) (100 ng/hr) alone or in combination on direct recording of mean arterial pressure in conscious spontaneously hypertensive rats. During an 11-day time-control infusion of isotonic saline vehicle (100 /tl/hr), mean arterial pressure remained stable. Chronic infusion of atriopeptin-(103-126) decreased mean arterial pressure progressively over the first 3 days; then mean arterial pressure progressively rose to control level over the following 3 days and remained at control level for the remainder of the experiment Similarly, coinfusions of atriopeptin-(103-126) and SC-46542 or thiorphan, SC-46542 and thiorphan, or the triple infusion of atriopeptin-(103-126), SC-46542, and thiorphan had only transient effects on mean arterial pressure during 10-day infusions. SC-46542 alone had no effect on mean arterial pressure. Similarly, thiorphan alone had no effect on mean arterial pressure except at doses that blocked the acute pressor response to angiotensin I. Chronic infusions of atriopeptin-(103-126), SC-46542, and thiorphan alone or in combination are not effective long-term treatments for hypertension in spontaneously hypertensive rats. (Hypertension 1990; 16:642-647)

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Section: Discussionmentioning

confidence: 99%

Chronic atriopeptin regulation of arterial pressure in conscious hypertensive rats.

et al. 1990

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“…30 Although differences in potencies were observed for the first two biological actions, the three peptides had equal potencies for the longterm blood pressure-lowering effect when infused at 0.4nmol-h-'-kg-' (approximately 15 ng-min-'-kg" 1 ). It is reasonable to assume, although it was not documented, that the circulating level of ANF achieved by this dose did not exceed the physiological range.…”

Section: Prolonged Infusionmentioning

confidence: 94%

An update on the physiology of atrial natriuretic factor.

Trippodo

1987

Hypertension

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SUMMARY The atrial natriuretic factor (ANF) has pharmacological actions resulting in lower atrial and arterial pressures. Atrial distention stimulates ANF release, suggesting that ANF is an effector limb of a feedback loop for controlling cardiac filling pressure. To test this hypothesis it will be necessary to determine whether physiological atrial distention releases ANF in sufficient amounts to exert biological actions. Immunoblockade of endogenous ANF and attenuation of ANF release by atrial ablation inhibited volume-induced natriuresis in rats. Infusion of ANF in rats at doses mimicking those observed during experimental volume expansion produced a natriuresis sufficient to partly account for the volume-induced response. Infusion of ANF at doses expected to change plasma ANF levels minimally decreased arterial pressure in hypertensive rats over 7 days. In dogs, some studies suggest that increased plasma ANF levels following experimental changes in atrial pressure were not sufficient to exert acute cardiovascular or renal actions, whereas others support such a notion and indicate that ANF inhibited barostimulated renal renin release. This last action could alter arterial pressure in the long term by allowing sodium equilibrium at lower renal arterial pressure. Infusion of ANF in humans that produced plasma levels in the upper physiological range caused increased sodium excretion and decreased plasma renin activity. Although data are exiguous, justifying neither acceptance nor rejection of the hypothesis that ANF functions physiologically to regulate body fluid volume and arterial pressure, the current evidence slightly favors acceptance. T HIS discussion reviews recent data relating to the possible physiological relevance of the atrial natriuretic factor (ANF) as a regulator of urinary sodium excretion and arterial blood pressure.

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Smooth Muscle Relaxing, Acute and Long-Term Blood Pressure Lowering Effects of Atriopeptins

Cited by 2 publications

References 0 publications

Chronic atriopeptin regulation of arterial pressure in conscious hypertensive rats.

Chronic atriopeptin regulation of arterial pressure in conscious hypertensive rats.

An update on the physiology of atrial natriuretic factor.

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