2008
DOI: 10.1371/journal.pone.0003217
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Snake Cathelicidin from Bungarus fasciatus Is a Potent Peptide Antibiotics

Abstract: BackgroundCathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules of innate immunity, which are firstly found in mammalians. Recently, several cathelicidins have also been found from chickens and fishes. No cathelicidins from other non-mammalian vertebrates have been reported.Principal FindingsIn this work, a cathelicidin-like antimicrobial peptide named cathelicidin-BF has been purified from the snake venoms of Bungarus fasciatus and its cDNA sequence was cloned from … Show more

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Cited by 214 publications
(199 citation statements)
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“…In contrast to defensins, most cathelicidins are linear molecules that lack disulfide bridges. A cathelicidin, known as cathelicidin-BF, has been identified in venom from the banded krait Bungarus fasciatus (Wang et al, 2008). Cathelicidin-BF exhibited strong antimicrobial activity against Gram-negative bacteria, some strains of Gram-positive bacteria, including those from the genus Bacillus, as well as activity against several fungi, including C. albicans.…”
Section: Innate Immunitymentioning
confidence: 99%
See 1 more Smart Citation
“…In contrast to defensins, most cathelicidins are linear molecules that lack disulfide bridges. A cathelicidin, known as cathelicidin-BF, has been identified in venom from the banded krait Bungarus fasciatus (Wang et al, 2008). Cathelicidin-BF exhibited strong antimicrobial activity against Gram-negative bacteria, some strains of Gram-positive bacteria, including those from the genus Bacillus, as well as activity against several fungi, including C. albicans.…”
Section: Innate Immunitymentioning
confidence: 99%
“…Cathelicidin-BF exhibited strong antimicrobial activity against Gram-negative bacteria, some strains of Gram-positive bacteria, including those from the genus Bacillus, as well as activity against several fungi, including C. albicans. In many cases, cathelicidin-BF was more potent than ampicillin and benzylpenicillin and was even effective against clinically isolated drug resistant Salmonella typhi and Klebsiella pneumoniae (Wang et al, 2008). A small cationic protein was isolated from the Siamese crocodile (Crocodylus siamensis), which demonstrated antibacterial activity against S. typhi, E. coli, S. aureus, Staphylococcus epidermidis, K. pneumoniae, P. aeruginosa and Vibrio chorelae (Preecharram et al, 2008).…”
Section: Innate Immunitymentioning
confidence: 99%
“…)。目前, 人、小鼠、兔、羊、 牛、猪、马、驴、鸡、狗、猫和金环蛇等许多物种 中发现的 cathelicidins 均属于 α-螺旋型, 如 LL-37 (Agerberth et al, 1995) 、 BMAP-27 、 CAP-18 、 Pc-CATHs 、Cc-CATHs 、K9CATH、feCath 和 cathelicidin-BF (Wang et al, 2008)等。延伸-螺旋 cathelicidins, 如 indolicidin 和富含 Pro 的抗菌肽类, 因含有特殊的氨基酸组成, 不易形成 α-螺旋构型, 而折叠成了更细长的结构。 包括牛的 Bac4、5、7 和 indolicidin (Scocchi et al, 1998), 来源于山羊的 Bac5, 猪的 prophenin-1、2 和 PR-39 (Pungerčar et al, 1993)等。…”
Section: Cathelicidinsunclassified
“…μg/ml、0.6 μg/ml 和 1.2 μg/ml (Wang et al, 2008) (Tamamura et al, 1995;Qu et al, 1996;Yasin et al, 1996;Lehrer & Ganz, 1996) (Shi et al, 1996), 而且 PR-39 诱导 小鼠间质细胞表面硫酸类肝素蛋白多糖 syndecan-1 和 syndecan-4 的表达, 促进组织损伤的修复 (Shi et al, 1996) …”
Section: Cathelicidinsunclassified
“…obs.). Interestingly, snake venom contains biologically active peptides with antimicrobial activity (Lima et al, 2005;Wang et al, 2008).…”
Section: It Is Not Possible To Eliminate Salmonella From the Digestivmentioning
confidence: 99%