Snakebites in Pediatric Patients in Kahramanmaraş: Is Pro-brain Natriuretic Peptide a Prognostic Biomarker for Snakebites?

İpek, Sevcan; Güngör, Şükrü; Güllü, Ufuk Utku; Dalkıran, Tahir; Mercan, M. Ertugrul; Demiray, Şeyma; Gürbüz, Yunus

doi:10.7759/cureus.21570

Cited by 2 publications

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References 26 publications

(29 reference statements)

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“…In another study conducted in adult patients with CO poisoning, NT-proBNP > 100 pg/mL at admission was found to be a significant marker in predicting left ventricular dysfunction [ 28 ]. In our previous studies, we reported the prognostic value of proBNP in various poisonings such as snake bites and scorpion bites [ 29 , 30 ]. We also showed that it was predictive of cardiac involvement in children with COVID-19 at the time of admission [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

The effect of full blood count and cardiac biomarkers on prognosis in carbon monoxide poisoning in children

et al. 2022

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Aims In this study, cardiac biomarkers, blood parameters, electrocardiography (ECG), and echocardiography were investigated in children with carbon monoxide (CO) poisoning, and the diagnostic value of these parameters was investigated. Methods The demographical, clinical, and laboratory data of children aged 0–18 years who were admitted to the pediatric emergency department due to CO poisoning between January 2019 and January 2022 were retrospectively scanned from medical records. The patients were divided into two groups as troponin-I positive and troponin-I negative. Results There were 107 children aged 0–18 years (average age, 10.46 ± 5.77 years; 51% female) with CO poisoning. There were 13 patients with troponin-I positive myocardial injury. Troponin-I was positive in 3 patients whose carboxyhemoglobin (COHb) level was below 2% at the time of admission. In one patient, troponin-I, which was normal at admission, increased by the 24th hour of hospitalization. Hyperbaric oxygen therapy was given due to headache in one patient, although the COHb level of that patient was below 25%. An NT-proBNP level of ≥ 219.5 ng/L predicted the development of troponin-I positivity with a sensitivity of 70% and a specificity of 86.7% (AUC, 0.967 (0.58–0.994); p = 0.017). White blood cell (WBC), neutrophil, neutrophil-to-lymphocyte ratio (NLR), immature granulocyte (IG), and IG% levels were found to be significantly higher in the troponin-positive patient group. Discussion and conclusion NT-proBNP has been shown to be an early diagnostic marker for myocardial dysfunction. Additionally, when cardiac markers are not available, full blood parameters may assist clinicians for patient treatment and referral.

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Section: Discussionmentioning

confidence: 99%

The effect of full blood count and cardiac biomarkers on prognosis in carbon monoxide poisoning in children

et al. 2022

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“…However, a few months later, he complained about hyperalgesia, swelling, alternating cool and warm sensation, and dermal changes, and was then diagnosed with complex regional pain syndrome (CRPS), which is a rare case reported by snakebites in the world [ 59 ]. In addition, two cases of pediatric CRPS (<18-year-old) were reported to be bitten by a viper and southern Pacific rattlesnake in Turkey [ 62 ] and the US [ 63 ], respectively.…”

Section: Envenoming By Rear-fanged Snakesmentioning

confidence: 99%

Cerebral Complications of Snakebite Envenoming: Case Studies

Lin

Chen

Liu

et al. 2022

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There are an estimated 5.4 million snakebite cases every year. People with snakebite envenoming suffer from severe complications, or even death. Although some review articles cover several topics of snakebite envenoming, a review of the cases regarding cerebral complications, especially rare syndromes, is lacking. Here, we overview 35 cases of snakebite by front-fanged snakes, including Bothrops, Daboia, Cerastes, Deinagkistrodon, Trimeresurus, and Crotalus in the Viperidae family; Bungarus and Naja in the Elapidae family, and Homoroselaps (rare cases) in the Lamprophiidae family. We also review three rare cases of snakebite by rear-fanged snakes, including Oxybelis and Leptodeira in the Colubridae family. In the cases of viper bites, most patients (17/24) were diagnosed with ischemic stroke and intracranial hemorrhage, leading to six deaths. We then discuss the potential underlying molecular mechanisms that cause these complications. In cases of elapid bites, neural, cardiac, and ophthalmic disorders are the main complications. Due to the small amount of venom injection and the inability to deep bite, all the rear-fanged snakebites did not develop any severe complications. To date, antivenom (AV) is the most effective therapy for snakebite envenoming. In the six cases of viper and elapid bites that did not receive AV, three cases (two by viper and one by elapid) resulted in death. This indicates that AV treatment is the key to survival after a venomous snakebite. Lastly, we also discuss several studies of therapeutic agents against snakebite-envenoming-induced complications, which could be potential adjuvants along with AV treatment. This article organizes the diagnosis of hemotoxic and neurotoxic envenoming, which may help ER doctors determine the treatment for unidentified snakebite.

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Snakebites in Pediatric Patients in Kahramanmaraş: Is Pro-brain Natriuretic Peptide a Prognostic Biomarker for Snakebites?

Cited by 2 publications

References 26 publications

The effect of full blood count and cardiac biomarkers on prognosis in carbon monoxide poisoning in children

The effect of full blood count and cardiac biomarkers on prognosis in carbon monoxide poisoning in children

Cerebral Complications of Snakebite Envenoming: Case Studies

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