SNHG10/miR‐141‐3p/WTAP axis promotes osteosarcoma proliferation and migration

Abstract

LncRNAs have been suggested to participate in the growth and metastasis of cancer through a variety of molecular mechanisms. Recently, SNHG10, a newly discovered lncRNA, is reported to play a role of an oncogene in osteosarcoma (OS) genesis. Nonetheless, the mechanism underlying OS remains unclear. The present work found that SNHG10 expression increased within OS cells and tissues, while suppressing its expression decreased OS cell proliferation, migration, invasion, but increased their apoptosis. As for the mechanism, we confirmed that SNHG10 could bind to miR‐141‐3p, while the latter could bind to WTAP. SNHG10 upregulated WTAP through decreasing miR‐141‐3p expression. More importantly, SNHG10 deletion remarkably reduced proliferation, migration, and invasion of cells, but accelerated their apoptosis. However, when cells were subjected to miR‐141‐3p inhibitor cotransfection or overexpressed WTAP, these effects were partially recovered. In summary, this study suggested that the expression of SNHG10 markedly elevated within OS, and the SNHG10/miR‐141‐3p/WTAP axis facilitated OS progression.

Circ_LDLR promotes the progression of papillary thyroid carcinoma by regulating miR‐1294/HMGB3 axis

“…[29] Nonetheless, the expression and mecha- MiRNAs can bind with mRNA to regulate target gene levels posttranscriptionally, so as to regulate mRNA expression level. [30][31][32][33] As suggested by dual-luciferase reporter assays, HMGB3 was served as miR-1294′s target. As an oncogene, HMGB3 is related to cancer cell progression.…”

RNA m6Amethylation in cancer

“…WTAP, which is mainly regulated by ncRNAs in cancers, is commonly up‐regulated in many cancer types [ 156 , 157 ]. In osteosarcoma, SNHG10 up‐regulates WTAP through decreasing miR‐141‐3p expression [ 158 ]. In BCA, circ0008399 binds to WTAP to promote the formation of MTC [ 159 ].…”

Role of WTAP in Cancer: From Mechanisms to the Therapeutic Potential

“…Therefore, ceRNA regulatory network can be used as an indicator for prognosis [ 75 ]. LncRNA SNHG10 competes for binding miR-141-3p by acting as a ceRNA to upregulate WTAP expression in osteosarcoma [ 76 ]. In pancreatic cancer, lncRNA DUXAP8 competitively binds miR-448 to upregulate WTAP expression [ 77 ].…”

“…lncRNA SNHG10 silencing leads to the inhibition of cell proliferation, migration, and invasion and the promotion of apoptosis. These phenotypes were rescued upon WTAP overexpression [ 76 ].…”