No abstract

LncRNAs have been suggested to participate in the growth and metastasis of cancer through a variety of molecular mechanisms. Recently, SNHG10, a newly discovered lncRNA, is reported to play a role of an oncogene in osteosarcoma (OS) genesis. Nonetheless, the mechanism underlying OS remains unclear. The present work found that SNHG10 expression increased within OS cells and tissues, while suppressing its expression decreased OS cell proliferation, migration, invasion, but increased their apoptosis. As for the mechanism, we confirmed that SNHG10 could bind to miR‐141‐3p, while the latter could bind to WTAP. SNHG10 upregulated WTAP through decreasing miR‐141‐3p expression. More importantly, SNHG10 deletion remarkably reduced proliferation, migration, and invasion of cells, but accelerated their apoptosis. However, when cells were subjected to miR‐141‐3p inhibitor cotransfection or overexpressed WTAP, these effects were partially recovered. In summary, this study suggested that the expression of SNHG10 markedly elevated within OS, and the SNHG10/miR‐141‐3p/WTAP axis facilitated OS progression.

In this study, highly fluorescent core/shell SiO2@CdTe nanoparticles (NPs) were synthesized conveniently and efficiently via hydrothermal method. The as-prepared SiO2@CdTe NPs were uniform with good fluorescence preservation. The SiO2@CdTeNPs could be used in the detection of H2O2 rapidly and sensitively within several minutes. Excellent linear relationships existed between the quenching degrees of the SiO2@CdTe NPs and the concentration of H2O2 in the range of 0.005 mM to 0.1 mM. The limit of detection (LOD) for H2O2 was 10 nM. Furthermore, it was proved that SiO2@CdTe NPs could be used repeatedly in the detection due to their feature of easy to separate. The excellent performance of SiO2@CdTe NPs would facilitate their applications in chemistry or biology detection.