SNPector: SNP inspection tool for diagnosing gene pathogenicity and drug response in a naked sequence

Abstract

Due to the ability to diagnose diseases early and evaluate the effectiveness of medicinal drugs, single nucleotide polymorphism (SNP) identification receives significant interest. Detection and diagnosis of genetic variation through skill-less computational tools would help researchers reducing the severity of such health complications and improving well-tailored therapies using discovered and previously known information. We introduce SNPector, which is a standalone SNP inspection software, which can be used to diagnose gene pathogenicity and drug reaction in naked genomic sequences. It identifies and extracts gene-related SNPs, and reports their genomic position, associated phenotype disorder, associated diseases, linkage disequilibrium, in addition to various drug reaction information. SNPector detects and verifies the existence of an SNP in a given DNA sequence based on different clinically relevant SNP databases, such as NCBI ClinVar, AWESOME, and PharmGKB, and generates highly informative visualizations of the recovered information.

Assessment of Machine Learning Algorithms for Prediction of Breast Cancer Malignancy Based on Mammogram Numeric Data

“…The results are shown in Fig.2.After analysis of produced data,Ada-boost Classifier shows 100%,100%,100%,100%,0,and 0 with Adjusted Rand Score,Homogeneity Score,R 2 . CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.…”

“…When she lives at 85, one in eight(12%)is likely to develop breast cancer sometime in her lifetime. When a woman ages, she increases dramatically her risk of developing breast cancer independently of her family history [1].Most of the cancer development caused by mutation, especially single nucleotide polymorphism(SNP), in genes such as BRCA1which is the most common gene occurs in breast and ovarian cancer [2] The aim of early diagnostic strategies is not only to provide quick access to cancer treatment but also to promote reliable diagnostic facilities. Screening requires the detection of tumors through screening people for signs before they are affected.…”

“…When a woman ages, she increases dramatically her risk of developing breast cancer independently of her family history[1]. Most of the cancer development caused by mutation, especially single nucleotide polymorphism(SNP), in genes such as BRCA1which is the most common gene occurs in breast and ovarian cancer[2]…”

In Silico Analysis of 716 Natural Bioactive Molecules Form Atlantic Ocean Reveals Candidate Molecule to Inhibit Spike Protein 

“…The rest of each molecule probabilities provided in supplementary(2). to build the network, We used SNPector's (Habib et al 2020) Network construction python script to build and visualize a network show the unique and shared targets between different molecules and generate an HTML interactive network as shown in gure (10). we also built a network to show the unique and shared target classes, probabilities, and genes.…”